FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800845087> ?p ?o ?g. }

• W2800845087 abstract "The aim of this study was to compare the pharmacokinetics (PK) and safety profiles of a fixed-dose combination (FDC) formulation of fimasartan, amlodipine, and rosuvastatin with the co-administration of the two products by using a replicated crossover study design in healthy male subjects.This was an open-label, randomized, three-sequence, three-period replicated crossover study in healthy male subjects. The replicated crossover design was done because of high coefficient of variation of PK parameter for fimasartan, that is, >30%. With a 14 days washout period, an FDC tablet containing 60 mg fimasartan, 10 mg amlodipine, and 20 mg rosuvastatin was administered only once, and separate formulations of fimasartan/amlodipine 60 mg/10 mg FDC tablet and 20 mg rosuvastatin tablet administered twice. Blood samples were collected up to 72 hours following drug administration. The plasma concentrations of fimasartan, amlodipine, and rosuvastatin were measured by liquid chromatography tandem mass spectrometry. Safety was assessed by evaluating vital signs, clinical laboratory parameters, physical examinations, and medical interviews.The geometric mean ratios and 90% confidence intervals (CIs) for the maximum plasma concentration (Cmax) and area under the curve from time zero to the last measurable sampling time (AUCt) were 1.0776 (0.9201-1.2622) and 0.9978 (0.9538-1.0439) for fimasartan, 1.0038 (0.9782-1.0301) and 1.0055 (0.9828-1.0288) for amlodipine, and 1.0006 (0.9290-1.0776) and 0.9986 (0.9532-1.0461) for rosuvastatin, respectively. A total of 22 adverse events (AEs) were reported by 60 subjects; there were no significant differences in the incidence of AEs between the two groups.The 90% CI of the Cmax of fimasartan was within the widened acceptance limit, ln(0.6984)-ln(1.4319). The 90% CIs of the other PK parameters for drugs were between ln(0.8) and ln(1.25). These results suggest that the FDC formulation is pharmacokinetically bioequivalent and has a similar safety profile, to the co-administration of its three constituent drugs." @default.
• W2800845087 created "2018-05-17" @default.
• W2800845087 creator A5023891207 @default.
• W2800845087 creator A5025115024 @default.
• W2800845087 creator A5032711040 @default.
• W2800845087 creator A5058329575 @default.
• W2800845087 creator A5082055335 @default.
• W2800845087 date "2018-05-01" @default.
• W2800845087 modified "2023-10-02" @default.
• W2800845087 title "Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects" @default.
• W2800845087 cites W1519606611 @default.
• W2800845087 cites W1590308968 @default.
• W2800845087 cites W1967610947 @default.
• W2800845087 cites W1974719260 @default.
• W2800845087 cites W1976670793 @default.
• W2800845087 cites W1987191616 @default.
• W2800845087 cites W2000868686 @default.
• W2800845087 cites W2030533439 @default.
• W2800845087 cites W2031185570 @default.
• W2800845087 cites W2054498854 @default.
• W2800845087 cites W2085312558 @default.
• W2800845087 cites W2126125759 @default.
• W2800845087 cites W2129858452 @default.
• W2800845087 cites W2137530351 @default.
• W2800845087 cites W2154704322 @default.
• W2800845087 cites W2167557672 @default.
• W2800845087 cites W2169731574 @default.
• W2800845087 cites W2343563882 @default.
• W2800845087 cites W2411630805 @default.
• W2800845087 doi "https://doi.org/10.2147/dddt.s164215" @default.
• W2800845087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5951219" @default.
• W2800845087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29780236" @default.
• W2800845087 hasPublicationYear "2018" @default.
• W2800845087 type Work @default.
• W2800845087 sameAs 2800845087 @default.
• W2800845087 citedByCount "5" @default.
• W2800845087 countsByYear W28008450872019 @default.
• W2800845087 countsByYear W28008450872020 @default.
• W2800845087 countsByYear W28008450872021 @default.
• W2800845087 countsByYear W28008450872022 @default.
• W2800845087 crossrefType "journal-article" @default.
• W2800845087 hasAuthorship W2800845087A5023891207 @default.
• W2800845087 hasAuthorship W2800845087A5025115024 @default.
• W2800845087 hasAuthorship W2800845087A5032711040 @default.
• W2800845087 hasAuthorship W2800845087A5058329575 @default.
• W2800845087 hasAuthorship W2800845087A5082055335 @default.
• W2800845087 hasBestOaLocation W28008450871 @default.
• W2800845087 hasConcept C112705442 @default.
• W2800845087 hasConcept C126322002 @default.
• W2800845087 hasConcept C126894567 @default.
• W2800845087 hasConcept C142724271 @default.
• W2800845087 hasConcept C204787440 @default.
• W2800845087 hasConcept C27081682 @default.
• W2800845087 hasConcept C2776623344 @default.
• W2800845087 hasConcept C2779384505 @default.
• W2800845087 hasConcept C2779646130 @default.
• W2800845087 hasConcept C2780499067 @default.
• W2800845087 hasConcept C42404028 @default.
• W2800845087 hasConcept C71924100 @default.
• W2800845087 hasConcept C84393581 @default.
• W2800845087 hasConcept C87813604 @default.
• W2800845087 hasConcept C98274493 @default.
• W2800845087 hasConceptScore W2800845087C112705442 @default.
• W2800845087 hasConceptScore W2800845087C126322002 @default.
• W2800845087 hasConceptScore W2800845087C126894567 @default.
• W2800845087 hasConceptScore W2800845087C142724271 @default.
• W2800845087 hasConceptScore W2800845087C204787440 @default.
• W2800845087 hasConceptScore W2800845087C27081682 @default.
• W2800845087 hasConceptScore W2800845087C2776623344 @default.
• W2800845087 hasConceptScore W2800845087C2779384505 @default.
• W2800845087 hasConceptScore W2800845087C2779646130 @default.
• W2800845087 hasConceptScore W2800845087C2780499067 @default.
• W2800845087 hasConceptScore W2800845087C42404028 @default.
• W2800845087 hasConceptScore W2800845087C71924100 @default.
• W2800845087 hasConceptScore W2800845087C84393581 @default.
• W2800845087 hasConceptScore W2800845087C87813604 @default.
• W2800845087 hasConceptScore W2800845087C98274493 @default.
• W2800845087 hasLocation W28008450871 @default.
• W2800845087 hasLocation W28008450872 @default.
• W2800845087 hasLocation W28008450873 @default.
• W2800845087 hasLocation W28008450874 @default.
• W2800845087 hasOpenAccess W2800845087 @default.
• W2800845087 hasPrimaryLocation W28008450871 @default.
• W2800845087 hasRelatedWork W1483349682 @default.
• W2800845087 hasRelatedWork W1723438945 @default.
• W2800845087 hasRelatedWork W2000868686 @default.
• W2800845087 hasRelatedWork W2024491490 @default.
• W2800845087 hasRelatedWork W2039657099 @default.
• W2800845087 hasRelatedWork W2079341304 @default.
• W2800845087 hasRelatedWork W2108867382 @default.
• W2800845087 hasRelatedWork W2124394654 @default.
• W2800845087 hasRelatedWork W2313337780 @default.
• W2800845087 hasRelatedWork W2331764565 @default.
• W2800845087 hasRelatedWork W2534104811 @default.
• W2800845087 hasRelatedWork W2547041992 @default.
• W2800845087 hasRelatedWork W2809239379 @default.
• W2800845087 hasRelatedWork W2883468130 @default.
• W2800845087 hasRelatedWork W2892019790 @default.
• W2800845087 hasRelatedWork W2976602661 @default.
• W2800845087 hasRelatedWork W3083879454 @default.

• next