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• W2800848134 abstract "Objective This study investigated whether there is an association between semiology of status epilepticus (SE) and response to treatment and outcome. Method Two hundred ninety-eight consecutive adult patients (160 females, 138 males) with SE at the University of Munich Hospital were prospectively enrolled. Mean age was 63.2 ± 17.5 (18–97) years. Patient demographics, SE semiology and electroencephalography (EEG) findings, etiology, duration of SE, treatment, and outcome measures were investigated. Status epilepticus semiology was classified according to a semiological status classification. Patient's short-term outcome was determined by Glasgow Outcome Scale (GOS). Results The most frequent SE type was nonconvulsive SE (NCSE) (39.2%), mostly associated with cerebrovascular etiology (46.6%). A potentially fatal etiology was found in 34.8% of the patients. More than half (60.7%) of the patients had poor short-term outcome (GOS ≤ 3) with an overall mortality of 12.4%. SE was refractory to treatment in 21.5% of the patients. Older age, potentially fatal etiology, systemic infections, NCSE in coma, refractory SE, treatment with anesthetics, long SE duration (>24 h), low Glasgow Coma Scale (GCS) (≤8) at onset, and high Status Epilepticus Severity Score (STESS-3) (≥3) were associated with poor short-term outcome and death (p < 0.05). Potentially fatal etiology and low GCS were the strongest predictors of poor outcome (Exp [b]: 4.74 and 4.10 respectively, p < 0.05). Conclusion Status epilepticus semiology has no independent association with outcome, but potentially fatal etiology and low GCS were strong predictive factors for poor short-term outcome of SE." @default.
• W2800848134 created "2018-05-17" @default.
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• W2800848134 date "2018-06-01" @default.
• W2800848134 modified "2023-10-18" @default.
• W2800848134 title "Does semiology of status epilepticus have an impact on treatment response and outcome?" @default.
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• W2800848134 doi "https://doi.org/10.1016/j.yebeh.2018.03.027" @default.
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