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• W2800867752 endingPage "e0197048" @default.
• W2800867752 startingPage "e0197048" @default.
• W2800867752 abstract "Heterozygous Bmp4 mutations in humans and mice cause severe ocular anterior segment dysgenesis (ASD). Abnormalities include pupil displacement, corneal opacity, iridocorneal adhesions, and variable intraocular pressure, as well as some retinal and vascular defects. It is presently not known what source of BMP4 is responsible for these defects, as BMP4 is expressed in several developing ocular and surrounding tissues. In particular, BMP4 is expressed in the ciliary margins of the optic cup which give rise to anterior segment structures such as the ciliary body and iris, making it a good candidate for the required source of BMP4 for anterior segment development. Here, we test whether ciliary margin-derived BMP4 is required for ocular development using two different conditional knockout approaches. In addition, we compared the conditional deletion phenotypes with Bmp4 heterozygous null mice. Morphological, molecular, and functional assays were performed on adult mutant mice, including histology, immunohistochemistry, in vivo imaging, and intraocular pressure measurements. Surprisingly, in contrast to Bmp4 heterozygous mutants, our analyses revealed that the anterior and posterior segments of Bmp4 conditional knockouts developed normally. These results indicate that ciliary margin-derived BMP4 does not have a major role in ocular development, although subtle alterations could not be ruled out. Furthermore, we demonstrated that the anterior and posterior phenotypes observed in Bmp4 heterozygous animals showed a strong propensity to co-occur, suggesting a common, non-cell autonomous source for these defects." @default.
• W2800867752 created "2018-05-17" @default.
• W2800867752 creator A5063753662 @default.
• W2800867752 creator A5064072378 @default.
• W2800867752 creator A5080809283 @default.
• W2800867752 date "2018-05-08" @default.
• W2800867752 modified "2023-09-24" @default.
• W2800867752 title "Ciliary margin-derived BMP4 does not have a major role in ocular development" @default.
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• W2800867752 doi "https://doi.org/10.1371/journal.pone.0197048" @default.
• W2800867752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5940228" @default.
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• W2800867752 hasPublicationYear "2018" @default.
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