Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800926573> ?p ?o ?g. }
- W2800926573 endingPage "658" @default.
- W2800926573 startingPage "645" @default.
- W2800926573 abstract "The current studies envisage unravelling the underlying cellular internalisation mechanism of the systematically developed docetaxel (DTH) polyunsaturated fatty acid (PUFA) enriched self-nanoemulsifying lipidic micellar systems (SNELS). The concentration-, time- and cytotoxicity-related effects of DTH-SNELS on triple negative breast cancer (TNBC) MDA-MB-231 and non-TNBC MCF-7 cell lines were assessed through Presto-blue assay. Subsequently, rhodamine-123 (Rh-123) loaded SNELS were employed for evaluating their internalisation through flow cytometry and fluorescence microscopy, establishing it to be “clathrin-mediated” endocytic pathway. Apoptosis assay (65% cell death) and cell cycle distribution (47% inhibition at G2/M phase) further corroborated the cytotoxicity of DTH-SNELS towards cancerous cells. Biodistribution, histopathology and haematology studies indicated insignificant toxicity of the optimized formulation on vital organs. Preclinical anticancer efficacy studies using 7,12-dimethylbenzantracene (DMBA)-induced model construed significant reduction in breast tumor-volume. Overall, extensive in vitro and in vivo studies indicated the intracellular localization and cytotoxicity, suggesting DTH-SNELS as promising delivery systems for breast tumor therapeutics including TNBC." @default.
- W2800926573 created "2018-05-17" @default.
- W2800926573 creator A5016626306 @default.
- W2800926573 creator A5030498626 @default.
- W2800926573 creator A5034902895 @default.
- W2800926573 creator A5043816474 @default.
- W2800926573 creator A5045032651 @default.
- W2800926573 creator A5047025432 @default.
- W2800926573 creator A5047076813 @default.
- W2800926573 creator A5061002569 @default.
- W2800926573 creator A5081527574 @default.
- W2800926573 date "2018-10-01" @default.
- W2800926573 modified "2023-10-16" @default.
- W2800926573 title "Clathrin-mediated endocytic uptake of PUFA enriched self-nanoemulsifying lipidic systems (SNELS) of an anticancer drug against triple negative cancer and DMBA induced preclinical tumor model" @default.
- W2800926573 cites W147417678 @default.
- W2800926573 cites W1520286824 @default.
- W2800926573 cites W1552589960 @default.
- W2800926573 cites W1582634852 @default.
- W2800926573 cites W1849554333 @default.
- W2800926573 cites W1857266517 @default.
- W2800926573 cites W1970311282 @default.
- W2800926573 cites W1971574874 @default.
- W2800926573 cites W1972466496 @default.
- W2800926573 cites W1973087358 @default.
- W2800926573 cites W1981937857 @default.
- W2800926573 cites W1988263368 @default.
- W2800926573 cites W1988659687 @default.
- W2800926573 cites W1991622083 @default.
- W2800926573 cites W1992350696 @default.
- W2800926573 cites W1994756768 @default.
- W2800926573 cites W1995224853 @default.
- W2800926573 cites W1998981145 @default.
- W2800926573 cites W1999736153 @default.
- W2800926573 cites W2003651291 @default.
- W2800926573 cites W2021876818 @default.
- W2800926573 cites W2022321694 @default.
- W2800926573 cites W2028837722 @default.
- W2800926573 cites W2033775272 @default.
- W2800926573 cites W2037113966 @default.
- W2800926573 cites W2052606222 @default.
- W2800926573 cites W2064840895 @default.
- W2800926573 cites W2078951246 @default.
- W2800926573 cites W2080748908 @default.
- W2800926573 cites W2085522109 @default.
- W2800926573 cites W2087482110 @default.
- W2800926573 cites W2092451289 @default.
- W2800926573 cites W2101683327 @default.
- W2800926573 cites W2115604279 @default.
- W2800926573 cites W2121720480 @default.
- W2800926573 cites W2136132417 @default.
- W2800926573 cites W2139992429 @default.
- W2800926573 cites W2147748248 @default.
- W2800926573 cites W2155843895 @default.
- W2800926573 cites W2156394189 @default.
- W2800926573 cites W2159074577 @default.
- W2800926573 cites W2166699788 @default.
- W2800926573 cites W2192049920 @default.
- W2800926573 cites W2197271423 @default.
- W2800926573 cites W2237719304 @default.
- W2800926573 cites W2289988894 @default.
- W2800926573 cites W2316119912 @default.
- W2800926573 cites W2400230080 @default.
- W2800926573 cites W2409229404 @default.
- W2800926573 cites W2460587633 @default.
- W2800926573 cites W2521843004 @default.
- W2800926573 cites W2546096198 @default.
- W2800926573 cites W2561700100 @default.
- W2800926573 cites W2563286746 @default.
- W2800926573 cites W2597612977 @default.
- W2800926573 cites W2618484371 @default.
- W2800926573 cites W2626189354 @default.
- W2800926573 cites W2752991889 @default.
- W2800926573 cites W2753321571 @default.
- W2800926573 doi "https://doi.org/10.1016/j.msec.2018.05.010" @default.
- W2800926573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30033299" @default.
- W2800926573 hasPublicationYear "2018" @default.
- W2800926573 type Work @default.
- W2800926573 sameAs 2800926573 @default.
- W2800926573 citedByCount "14" @default.
- W2800926573 countsByYear W28009265732019 @default.
- W2800926573 countsByYear W28009265732020 @default.
- W2800926573 countsByYear W28009265732021 @default.
- W2800926573 countsByYear W28009265732022 @default.
- W2800926573 countsByYear W28009265732023 @default.
- W2800926573 crossrefType "journal-article" @default.
- W2800926573 hasAuthorship W2800926573A5016626306 @default.
- W2800926573 hasAuthorship W2800926573A5030498626 @default.
- W2800926573 hasAuthorship W2800926573A5034902895 @default.
- W2800926573 hasAuthorship W2800926573A5043816474 @default.
- W2800926573 hasAuthorship W2800926573A5045032651 @default.
- W2800926573 hasAuthorship W2800926573A5047025432 @default.
- W2800926573 hasAuthorship W2800926573A5047076813 @default.
- W2800926573 hasAuthorship W2800926573A5061002569 @default.
- W2800926573 hasAuthorship W2800926573A5081527574 @default.
- W2800926573 hasBestOaLocation W28009265732 @default.
- W2800926573 hasConcept C109316439 @default.
- W2800926573 hasConcept C121608353 @default.
- W2800926573 hasConcept C1491633281 @default.