Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800943392> ?p ?o ?g. }
- W2800943392 endingPage "531" @default.
- W2800943392 startingPage "516" @default.
- W2800943392 abstract "Abstract The present study investigates the potential of Carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion ( BCCA o)‐induced vascular dementia (VaD). Wistar rats were subjected to BCCA o procedure under anaesthesia to induce VaD. The rats were subjected to Morris water maze ( MWM ) test (6th day onwards post‐surgery). MWM test was employed to assess learning and memory of the animals whereby escape latency time, time spent in target quadrant and Path length (distance travelled) taken as important parameters. Serum nitrite level; Brain thiobarbituric acid reactive substances ( TBARS ) and reduced glutathione ( GSH ) levels; Brain acetylcholinesterase ( AC hE) activity; brain Myeloperoxidase activity ( MPO ) and neutrophil count were estimated as per standard procedures. BCCA o in rats produced a significant vascular endothelial dysfunction, as reflected by decrease in serum nitrite levels. Further, these animals showed poor performance on MWM , depicting impairment of learning and memory. There was a significant rise in brain oxidative stress level as indicated by increase in TBARS and decrease in GSH levels. An increase in brain AC hE activity was also observed. Moreover, these rats also exhibited an increase in MPO activity and neutrophil infiltration in brain (as marker of inflammation). Treatment of Carnosine (200 and 400 mg/kg, i.p.)/Donepezil (0.3 mg/kg, i.p.) ameliorated BCCA o‐induced memory deficits; endothelial dysfunction; biochemical and histopathological changes. It is concluded that Carnosine has shown efficacy in rat model of BCCA o‐induced VaD and can be considered as an important therapeutic agent for the treatment of VaD." @default.
- W2800943392 created "2018-05-17" @default.
- W2800943392 creator A5011711095 @default.
- W2800943392 creator A5025482083 @default.
- W2800943392 creator A5031712508 @default.
- W2800943392 creator A5064947153 @default.
- W2800943392 creator A5070579300 @default.
- W2800943392 date "2018-05-23" @default.
- W2800943392 modified "2023-10-14" @default.
- W2800943392 title "Potential of carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion-induced vascular dementia" @default.
- W2800943392 cites W127761954 @default.
- W2800943392 cites W1495600856 @default.
- W2800943392 cites W1511767312 @default.
- W2800943392 cites W1578359906 @default.
- W2800943392 cites W1775749144 @default.
- W2800943392 cites W1815207518 @default.
- W2800943392 cites W1967349573 @default.
- W2800943392 cites W1969450955 @default.
- W2800943392 cites W1970512939 @default.
- W2800943392 cites W1970849128 @default.
- W2800943392 cites W1971048984 @default.
- W2800943392 cites W1975081879 @default.
- W2800943392 cites W1977414387 @default.
- W2800943392 cites W1983310681 @default.
- W2800943392 cites W1984676487 @default.
- W2800943392 cites W1987385741 @default.
- W2800943392 cites W1990290618 @default.
- W2800943392 cites W1992191356 @default.
- W2800943392 cites W1994849924 @default.
- W2800943392 cites W2001740486 @default.
- W2800943392 cites W2005425449 @default.
- W2800943392 cites W2012660986 @default.
- W2800943392 cites W2016099094 @default.
- W2800943392 cites W2022484858 @default.
- W2800943392 cites W2023041924 @default.
- W2800943392 cites W2023549039 @default.
- W2800943392 cites W2027685112 @default.
- W2800943392 cites W2029653957 @default.
- W2800943392 cites W2037948061 @default.
- W2800943392 cites W2042270222 @default.
- W2800943392 cites W2043675663 @default.
- W2800943392 cites W2047199980 @default.
- W2800943392 cites W2048479544 @default.
- W2800943392 cites W2055433723 @default.
- W2800943392 cites W2055930558 @default.
- W2800943392 cites W2057849450 @default.
- W2800943392 cites W2061239292 @default.
- W2800943392 cites W2067968675 @default.
- W2800943392 cites W2068545219 @default.
- W2800943392 cites W2069800127 @default.
- W2800943392 cites W2075092696 @default.
- W2800943392 cites W2076880656 @default.
- W2800943392 cites W2076943504 @default.
- W2800943392 cites W2077587959 @default.
- W2800943392 cites W2078854975 @default.
- W2800943392 cites W2079145577 @default.
- W2800943392 cites W2088158006 @default.
- W2800943392 cites W2088445784 @default.
- W2800943392 cites W2089413904 @default.
- W2800943392 cites W2108287330 @default.
- W2800943392 cites W2112724172 @default.
- W2800943392 cites W2117089758 @default.
- W2800943392 cites W2120070267 @default.
- W2800943392 cites W2123035658 @default.
- W2800943392 cites W2129379282 @default.
- W2800943392 cites W2136497849 @default.
- W2800943392 cites W2137440027 @default.
- W2800943392 cites W2143765047 @default.
- W2800943392 cites W2145252529 @default.
- W2800943392 cites W2146673766 @default.
- W2800943392 cites W2149387202 @default.
- W2800943392 cites W2149986123 @default.
- W2800943392 cites W2151780081 @default.
- W2800943392 cites W2156601958 @default.
- W2800943392 cites W2157782111 @default.
- W2800943392 cites W2158296959 @default.
- W2800943392 cites W2168220191 @default.
- W2800943392 cites W2169473035 @default.
- W2800943392 cites W2214332662 @default.
- W2800943392 cites W2297219687 @default.
- W2800943392 cites W2297469630 @default.
- W2800943392 cites W2312628277 @default.
- W2800943392 cites W2314277084 @default.
- W2800943392 cites W2324980061 @default.
- W2800943392 cites W2329988659 @default.
- W2800943392 cites W2336853600 @default.
- W2800943392 cites W2337870401 @default.
- W2800943392 cites W2344457884 @default.
- W2800943392 cites W2398509536 @default.
- W2800943392 cites W2402289750 @default.
- W2800943392 cites W2462761278 @default.
- W2800943392 cites W2469310487 @default.
- W2800943392 cites W2472967819 @default.
- W2800943392 cites W2527609605 @default.
- W2800943392 cites W331491523 @default.
- W2800943392 cites W423996518 @default.
- W2800943392 cites W44915015 @default.
- W2800943392 cites W52886305 @default.