FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800943945> ?p ?o ?g. }

• W2800943945 endingPage "676" @default.
• W2800943945 startingPage "670" @default.
• W2800943945 abstract "Heartburn is the most specific symptom of reflux disease and is highly responsive to proton pump inhibitor (PPI) therapy. Some patients do not respond to PPIs, but mechanisms of refractoriness have not yet been fully elucidated. Impedance-pH monitoring, allowing comprehensive on-therapy assessment of reflux, represents a valuable test to investigate PPI refractoriness.Prospective multicenter study comparing endoscopy-negative patients with PPI-refractory and PPI-responsive heartburn. Reflux disease was demonstrated by off-PPI impedance-pH monitoring and mechanisms of refractoriness were studied with on-PPI impedance-pH monitoring. Assessment of impedance-pH tracings comprised conventional parameters, post-reflux swallow-induced peristaltic wave (PSPW) index, and mean nocturnal baseline impedance (MNBI).Sixty-four patients entered the study, 32 with PPI-refractory and 32 with PPI-responsive heartburn. On PPI, median percentage gastric and esophageal acid exposure time and number of acid refluxes did not differ between the two groups; conversely, number of total and weakly acidic refluxes and percentage bolus exposure were significantly higher while PSPW index and MNBI were significantly lower in PPI-refractory cases. At multivariate logistic regression analysis, PSPW index was the sole independent risk factor for PPI refractoriness (OR 1.082, 95% CI 1.022-1.146, P = 0.007). Comparing off- and on-PPI parameters, median PSPW index did not change in PPI-refractory patients (24% vs. 26%, P = 0.327) but increased significantly in PPI-responsive cases (29% vs. 46%, P < 0.001).Lack of improvement of impaired chemical clearance is a major determinant of PPI refractoriness. Timely post-reflux salivary swallowing represents a key defensive mechanism and a potential target for future treatment modalities in PPI-refractory reflux-related heartburn." @default.
• W2800943945 created "2018-05-17" @default.
• W2800943945 creator A5001660061 @default.
• W2800943945 creator A5018820955 @default.
• W2800943945 creator A5037439209 @default.
• W2800943945 creator A5046401726 @default.
• W2800943945 creator A5074099993 @default.
• W2800943945 creator A5078873097 @default.
• W2800943945 date "2018-05-01" @default.
• W2800943945 modified "2023-10-12" @default.
• W2800943945 title "Lack of improvement of impaired chemical clearance characterizes PPI-refractory reflux-related heartburn" @default.
• W2800943945 cites W1971264637 @default.
• W2800943945 cites W1995599980 @default.
• W2800943945 cites W2013018885 @default.
• W2800943945 cites W2037818023 @default.
• W2800943945 cites W2039575925 @default.
• W2800943945 cites W2046585771 @default.
• W2800943945 cites W2053896331 @default.
• W2800943945 cites W2058485844 @default.
• W2800943945 cites W2070851650 @default.
• W2800943945 cites W2071521423 @default.
• W2800943945 cites W2076554887 @default.
• W2800943945 cites W2106304772 @default.
• W2800943945 cites W2129792868 @default.
• W2800943945 cites W2148800153 @default.
• W2800943945 cites W2157778300 @default.
• W2800943945 cites W2419408094 @default.
• W2800943945 cites W2467687275 @default.
• W2800943945 cites W2517074250 @default.
• W2800943945 cites W2521035940 @default.
• W2800943945 cites W2552834347 @default.
• W2800943945 cites W2601059298 @default.
• W2800943945 cites W2617935560 @default.
• W2800943945 cites W2760799674 @default.
• W2800943945 cites W753130981 @default.
• W2800943945 doi "https://doi.org/10.1038/s41395-018-0044-5" @default.
• W2800943945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29681623" @default.
• W2800943945 hasPublicationYear "2018" @default.
• W2800943945 type Work @default.
• W2800943945 sameAs 2800943945 @default.
• W2800943945 citedByCount "55" @default.
• W2800943945 countsByYear W28009439452019 @default.
• W2800943945 countsByYear W28009439452020 @default.
• W2800943945 countsByYear W28009439452021 @default.
• W2800943945 countsByYear W28009439452022 @default.
• W2800943945 countsByYear W28009439452023 @default.
• W2800943945 crossrefType "journal-article" @default.
• W2800943945 hasAuthorship W2800943945A5001660061 @default.
• W2800943945 hasAuthorship W2800943945A5018820955 @default.
• W2800943945 hasAuthorship W2800943945A5037439209 @default.
• W2800943945 hasAuthorship W2800943945A5046401726 @default.
• W2800943945 hasAuthorship W2800943945A5074099993 @default.
• W2800943945 hasAuthorship W2800943945A5078873097 @default.
• W2800943945 hasBestOaLocation W28009439452 @default.
• W2800943945 hasConcept C121332964 @default.
• W2800943945 hasConcept C126322002 @default.
• W2800943945 hasConcept C142424586 @default.
• W2800943945 hasConcept C188816634 @default.
• W2800943945 hasConcept C2776462128 @default.
• W2800943945 hasConcept C2777014526 @default.
• W2800943945 hasConcept C2777683962 @default.
• W2800943945 hasConcept C2779134260 @default.
• W2800943945 hasConcept C2779949763 @default.
• W2800943945 hasConcept C2781025758 @default.
• W2800943945 hasConcept C43270747 @default.
• W2800943945 hasConcept C70616116 @default.
• W2800943945 hasConcept C71924100 @default.
• W2800943945 hasConcept C87355193 @default.
• W2800943945 hasConcept C90924648 @default.
• W2800943945 hasConceptScore W2800943945C121332964 @default.
• W2800943945 hasConceptScore W2800943945C126322002 @default.
• W2800943945 hasConceptScore W2800943945C142424586 @default.
• W2800943945 hasConceptScore W2800943945C188816634 @default.
• W2800943945 hasConceptScore W2800943945C2776462128 @default.
• W2800943945 hasConceptScore W2800943945C2777014526 @default.
• W2800943945 hasConceptScore W2800943945C2777683962 @default.
• W2800943945 hasConceptScore W2800943945C2779134260 @default.
• W2800943945 hasConceptScore W2800943945C2779949763 @default.
• W2800943945 hasConceptScore W2800943945C2781025758 @default.
• W2800943945 hasConceptScore W2800943945C43270747 @default.
• W2800943945 hasConceptScore W2800943945C70616116 @default.
• W2800943945 hasConceptScore W2800943945C71924100 @default.
• W2800943945 hasConceptScore W2800943945C87355193 @default.
• W2800943945 hasConceptScore W2800943945C90924648 @default.
• W2800943945 hasIssue "5" @default.
• W2800943945 hasLocation W28009439451 @default.
• W2800943945 hasLocation W28009439452 @default.
• W2800943945 hasLocation W28009439453 @default.
• W2800943945 hasOpenAccess W2800943945 @default.
• W2800943945 hasPrimaryLocation W28009439451 @default.
• W2800943945 hasRelatedWork W1774663261 @default.
• W2800943945 hasRelatedWork W1962373141 @default.
• W2800943945 hasRelatedWork W1963661468 @default.
• W2800943945 hasRelatedWork W2028010488 @default.
• W2800943945 hasRelatedWork W2038062995 @default.
• W2800943945 hasRelatedWork W2050947401 @default.
• W2800943945 hasRelatedWork W2148800153 @default.
• W2800943945 hasRelatedWork W2461403891 @default.

• next