FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800962323> ?p ?o ?g. }

• W2800962323 endingPage "200" @default.
• W2800962323 startingPage "192" @default.
• W2800962323 abstract "ObjectiveThe objective of this study was to explore whether chronic electrocorticographic (ECoG) data recorded by a responsive neurostimulation system could be used to assess clinical responses to antiepileptic drugs (AEDs).MethodsAntiepileptic drugs initiated and maintained for ≥3 months by patients participating in clinical trials of the RNS® System were identified. Such “AED Starts” that produced an additional ≥50% reduction in patient-reported clinical seizure frequency were categorized as clinically beneficial, and the remaining as not beneficial. Electrocorticographic features recorded by the RNS® Neurostimulator were analyzed during three periods: 3 months before the AED Start, first month after the AED Start, and the first 3 months after the AED Start.ResultsThe most commonly added medications were clobazam (n = 41), lacosamide (n = 96), levetiracetam (n = 31), and pregabalin (n = 25). Across all four medications, there were sufficient clinical data for 193 AED Starts to be included in the analyses, and 59 AED Starts were considered clinically beneficial. The proportion of AED Starts that qualified as clinically beneficial was higher for clobazam (53.7%) and levetiracetam (51.6%) than for lacosamide (18.8%) and pregabalin (12%). Across all AED Starts for which RNS ECoG detection settings were held constant, the clinically beneficial AED Starts were associated with a significantly greater reduction in the detection of epileptiform activity (p < 0.001) at 1 (n = 33) and 3 months (n = 30) compared with AED Starts that were not beneficial at 1 (n = 71) and 3 months (n = 60). Furthermore, there was a significant reduction in interictal spike rate and spectral power (1–125 Hz) associated with a clinically beneficial response to an AED Start at 1 (n = 32) and 3 months (n = 35) (p < 0.001). These reductions were not observed at either 1 (n = 59) or 3 months (n = 60) for AED Starts that were not clinically beneficial.ConclusionsSignificant quantitative changes in ECoG data recorded by the RNS System were observed in patients who experienced an additional clinical response to a new AED. While there was variability across patients in the changes observed, the results suggest that quantitative ECoG data may provide useful information when assessing whether a patient may have a favorable clinical response to an AED." @default.
• W2800962323 created "2018-05-17" @default.
• W2800962323 creator A5011773831 @default.
• W2800962323 creator A5067480695 @default.
• W2800962323 creator A5084959085 @default.
• W2800962323 date "2018-06-01" @default.
• W2800962323 modified "2023-10-10" @default.
• W2800962323 title "Clinical and electrocorticographic response to antiepileptic drugs in patients treated with responsive stimulation" @default.
• W2800962323 cites W1963617392 @default.
• W2800962323 cites W1970931021 @default.
• W2800962323 cites W1977688125 @default.
• W2800962323 cites W1979093403 @default.
• W2800962323 cites W1981560111 @default.
• W2800962323 cites W1997311416 @default.
• W2800962323 cites W1998691606 @default.
• W2800962323 cites W2003892165 @default.
• W2800962323 cites W2018930679 @default.
• W2800962323 cites W2023928221 @default.
• W2800962323 cites W2028522929 @default.
• W2800962323 cites W2030741897 @default.
• W2800962323 cites W203221303 @default.
• W2800962323 cites W2037997722 @default.
• W2800962323 cites W2038606869 @default.
• W2800962323 cites W2046394766 @default.
• W2800962323 cites W2048124453 @default.
• W2800962323 cites W2052048899 @default.
• W2800962323 cites W2059135669 @default.
• W2800962323 cites W2074961192 @default.
• W2800962323 cites W2077377551 @default.
• W2800962323 cites W2081035884 @default.
• W2800962323 cites W2083313829 @default.
• W2800962323 cites W2083410010 @default.
• W2800962323 cites W2093060063 @default.
• W2800962323 cites W2095421040 @default.
• W2800962323 cites W2114461073 @default.
• W2800962323 cites W2119130526 @default.
• W2800962323 cites W2133434651 @default.
• W2800962323 cites W2136104104 @default.
• W2800962323 cites W2146321872 @default.
• W2800962323 cites W2154214065 @default.
• W2800962323 cites W2158940042 @default.
• W2800962323 cites W2167309854 @default.
• W2800962323 cites W2288238997 @default.
• W2800962323 cites W2301514678 @default.
• W2800962323 cites W2465489214 @default.
• W2800962323 cites W2508403292 @default.
• W2800962323 cites W2769126173 @default.
• W2800962323 doi "https://doi.org/10.1016/j.yebeh.2018.04.003" @default.
• W2800962323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29719278" @default.
• W2800962323 hasPublicationYear "2018" @default.
• W2800962323 type Work @default.
• W2800962323 sameAs 2800962323 @default.
• W2800962323 citedByCount "41" @default.
• W2800962323 countsByYear W28009623232018 @default.
• W2800962323 countsByYear W28009623232019 @default.
• W2800962323 countsByYear W28009623232020 @default.
• W2800962323 countsByYear W28009623232021 @default.
• W2800962323 countsByYear W28009623232022 @default.
• W2800962323 countsByYear W28009623232023 @default.
• W2800962323 crossrefType "journal-article" @default.
• W2800962323 hasAuthorship W2800962323A5011773831 @default.
• W2800962323 hasAuthorship W2800962323A5067480695 @default.
• W2800962323 hasAuthorship W2800962323A5084959085 @default.
• W2800962323 hasBestOaLocation W28009623231 @default.
• W2800962323 hasConcept C118552586 @default.
• W2800962323 hasConcept C17755696 @default.
• W2800962323 hasConcept C2776468701 @default.
• W2800962323 hasConcept C2777332695 @default.
• W2800962323 hasConcept C2777907850 @default.
• W2800962323 hasConcept C2778139780 @default.
• W2800962323 hasConcept C2778186239 @default.
• W2800962323 hasConcept C2994127763 @default.
• W2800962323 hasConcept C42219234 @default.
• W2800962323 hasConcept C71924100 @default.
• W2800962323 hasConceptScore W2800962323C118552586 @default.
• W2800962323 hasConceptScore W2800962323C17755696 @default.
• W2800962323 hasConceptScore W2800962323C2776468701 @default.
• W2800962323 hasConceptScore W2800962323C2777332695 @default.
• W2800962323 hasConceptScore W2800962323C2777907850 @default.
• W2800962323 hasConceptScore W2800962323C2778139780 @default.
• W2800962323 hasConceptScore W2800962323C2778186239 @default.
• W2800962323 hasConceptScore W2800962323C2994127763 @default.
• W2800962323 hasConceptScore W2800962323C42219234 @default.
• W2800962323 hasConceptScore W2800962323C71924100 @default.
• W2800962323 hasLocation W28009623231 @default.
• W2800962323 hasLocation W28009623232 @default.
• W2800962323 hasOpenAccess W2800962323 @default.
• W2800962323 hasPrimaryLocation W28009623231 @default.
• W2800962323 hasRelatedWork W2089572838 @default.
• W2800962323 hasRelatedWork W2537478391 @default.
• W2800962323 hasRelatedWork W2586305460 @default.
• W2800962323 hasRelatedWork W2619533035 @default.
• W2800962323 hasRelatedWork W2742158623 @default.
• W2800962323 hasRelatedWork W2800962323 @default.
• W2800962323 hasRelatedWork W3206994722 @default.
• W2800962323 hasRelatedWork W4364353744 @default.
• W2800962323 hasRelatedWork W4381740638 @default.
• W2800962323 hasRelatedWork W3083444333 @default.

• next