FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800963498> ?p ?o ?g. }

• W2800963498 endingPage "370" @default.
• W2800963498 startingPage "364" @default.
• W2800963498 abstract "The existing therapies of IgA nephropathy are unsatisfying. Acteoside, the main component of Rehmannia glutinosa with anti-inflammatory and anti-immune effects, can improve urinary protein excretion and immune disorder. Th22 cell is involved in IgA nephropathy progression. This study was determined to explore the effect of acteoside on mesangial injury underlying Th22 cell disorder in IgA nephropathy. Serum Th22 cells and urine total protein of patients with IgA nephropathy were measured before and after six months treatment of Rehmannia glutinosa acteoside or valsartan. Chemotactic assay and co-culture assay were performed to investigate the effect of acteoside on Th22 cell chemotaxis and differentiation. The expression of CCL20, CCL22 and CCL27 were analyzed. To explore the effect of acteoside on mesangial cell injury induced by inflammation, IL-1, IL-6, TNF-α and TGF-β1 were tested. Results showed that the proteinuria and Th22 lymphocytosis of patients with IgA nephropathy significantly improved after combination treatment of Rehmannia glutinosa acteoside and valsartan, compared with valsartan monotherapy. In vitro study further demonstrated that acteoside inhibit Th22 cell chemotaxis by suppressing the production of Th22 cell attractive chemokines, i.e., CCL20, CCL22 and CCL27. In addition, acteoside inhibited the Th22 cell proliferation. Co-culture assay proved that acteoside could relieve the overexpression of pro-inflammatory cytokines, and prevent the synthesis of TGF-β1. TGF-β1 level in mesangial cells was positively correlated with the Th22 cell. This research demonstrated that acteoside can alleviate mesangial cell inflammatory injury by modulating Th22 lymphocytes chemotaxis and proliferation." @default.
• W2800963498 created "2018-05-17" @default.
• W2800963498 creator A5004788351 @default.
• W2800963498 creator A5009928424 @default.
• W2800963498 creator A5012154773 @default.
• W2800963498 creator A5039917854 @default.
• W2800963498 creator A5063253432 @default.
• W2800963498 creator A5067988551 @default.
• W2800963498 date "2018-04-30" @default.
• W2800963498 modified "2023-10-15" @default.
• W2800963498 title "Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy" @default.
• W2800963498 cites W1547680175 @default.
• W2800963498 cites W1590220622 @default.
• W2800963498 cites W168918095 @default.
• W2800963498 cites W1863868334 @default.
• W2800963498 cites W1965094772 @default.
• W2800963498 cites W1971365972 @default.
• W2800963498 cites W1975175944 @default.
• W2800963498 cites W1988628908 @default.
• W2800963498 cites W1989303997 @default.
• W2800963498 cites W1990104455 @default.
• W2800963498 cites W2020498525 @default.
• W2800963498 cites W2041108619 @default.
• W2800963498 cites W2042962529 @default.
• W2800963498 cites W2058105605 @default.
• W2800963498 cites W2082601321 @default.
• W2800963498 cites W2085456168 @default.
• W2800963498 cites W2094970346 @default.
• W2800963498 cites W2121014368 @default.
• W2800963498 cites W2268676806 @default.
• W2800963498 cites W2341294004 @default.
• W2800963498 cites W2342251436 @default.
• W2800963498 cites W2342679639 @default.
• W2800963498 cites W2519635405 @default.
• W2800963498 cites W2562550935 @default.
• W2800963498 cites W4211190065 @default.
• W2800963498 cites W4232976656 @default.
• W2800963498 doi "https://doi.org/10.1080/0886022x.2018.1450762" @default.
• W2800963498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6014492" @default.
• W2800963498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29708439" @default.
• W2800963498 hasPublicationYear "2018" @default.
• W2800963498 type Work @default.
• W2800963498 sameAs 2800963498 @default.
• W2800963498 citedByCount "25" @default.
• W2800963498 countsByYear W28009634982019 @default.
• W2800963498 countsByYear W28009634982020 @default.
• W2800963498 countsByYear W28009634982021 @default.
• W2800963498 countsByYear W28009634982022 @default.
• W2800963498 countsByYear W28009634982023 @default.
• W2800963498 crossrefType "journal-article" @default.
• W2800963498 hasAuthorship W2800963498A5004788351 @default.
• W2800963498 hasAuthorship W2800963498A5009928424 @default.
• W2800963498 hasAuthorship W2800963498A5012154773 @default.
• W2800963498 hasAuthorship W2800963498A5039917854 @default.
• W2800963498 hasAuthorship W2800963498A5063253432 @default.
• W2800963498 hasAuthorship W2800963498A5067988551 @default.
• W2800963498 hasBestOaLocation W28009634981 @default.
• W2800963498 hasConcept C126322002 @default.
• W2800963498 hasConcept C13373296 @default.
• W2800963498 hasConcept C134018914 @default.
• W2800963498 hasConcept C170493617 @default.
• W2800963498 hasConcept C203014093 @default.
• W2800963498 hasConcept C2776914184 @default.
• W2800963498 hasConcept C2779131090 @default.
• W2800963498 hasConcept C2780091579 @default.
• W2800963498 hasConcept C2781184683 @default.
• W2800963498 hasConcept C54166955 @default.
• W2800963498 hasConcept C555293320 @default.
• W2800963498 hasConcept C71924100 @default.
• W2800963498 hasConcept C98274493 @default.
• W2800963498 hasConceptScore W2800963498C126322002 @default.
• W2800963498 hasConceptScore W2800963498C13373296 @default.
• W2800963498 hasConceptScore W2800963498C134018914 @default.
• W2800963498 hasConceptScore W2800963498C170493617 @default.
• W2800963498 hasConceptScore W2800963498C203014093 @default.
• W2800963498 hasConceptScore W2800963498C2776914184 @default.
• W2800963498 hasConceptScore W2800963498C2779131090 @default.
• W2800963498 hasConceptScore W2800963498C2780091579 @default.
• W2800963498 hasConceptScore W2800963498C2781184683 @default.
• W2800963498 hasConceptScore W2800963498C54166955 @default.
• W2800963498 hasConceptScore W2800963498C555293320 @default.
• W2800963498 hasConceptScore W2800963498C71924100 @default.
• W2800963498 hasConceptScore W2800963498C98274493 @default.
• W2800963498 hasFunder F4320321001 @default.
• W2800963498 hasIssue "1" @default.
• W2800963498 hasLocation W28009634981 @default.
• W2800963498 hasLocation W28009634982 @default.
• W2800963498 hasLocation W28009634983 @default.
• W2800963498 hasLocation W28009634984 @default.
• W2800963498 hasOpenAccess W2800963498 @default.
• W2800963498 hasPrimaryLocation W28009634981 @default.
• W2800963498 hasRelatedWork W1698079933 @default.
• W2800963498 hasRelatedWork W2008983317 @default.
• W2800963498 hasRelatedWork W2028004294 @default.
• W2800963498 hasRelatedWork W2039065953 @default.
• W2800963498 hasRelatedWork W2099548299 @default.
• W2800963498 hasRelatedWork W2397091994 @default.
• W2800963498 hasRelatedWork W2408185273 @default.

• next