Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800973282> ?p ?o ?g. }
- W2800973282 endingPage "2462" @default.
- W2800973282 startingPage "2451" @default.
- W2800973282 abstract "The major biological form of selenium is that of the co-translationally inserted amino acid selenocysteine (Sec). In Archaea, the majority of proteins containing Sec, selenoproteins, are involved in methanogenesis. However, the function of this residue is often not known because selenium-independent homologs of the selenoproteins can be employed, sometimes even in one organism.This review summarizes current knowledge about the selenoproteins of Archaea, the metabolic pathways where they are involved, and discusses the (potential) function of individual Sec residues. Also, what is known about the archaeal way of selenoprotein synthesis, and the regulatory mechanism leading to the replacement of the selenoproteins with selenium-independent homologs, will be presented. Where appropriate, similarities with (and differences to) the respective steps employed in the other two domains, Bacteria and Eukarya, will be emphasized.Genetic and biochemical studies guided by analysis of genome sequences of Sec-encoding archaea has revealed that the pathway of Sec synthesis in Archaea and Eukarya are principally identical and that Sec insertion in Eukarya probably evolved from an archaeal mechanism employed prior to the separation of the archaeal and eukaryal lines of decent.In light of the emerging close phylogenetic relationship of Eukarya and Archaea, archaeal models may be highly valuable tools for unraveling eukaryotic principles in molecular and cell biology." @default.
- W2800973282 created "2018-05-17" @default.
- W2800973282 creator A5026749924 @default.
- W2800973282 creator A5072152901 @default.
- W2800973282 date "2018-11-01" @default.
- W2800973282 modified "2023-10-12" @default.
- W2800973282 title "Selenoprotein synthesis and regulation in Archaea" @default.
- W2800973282 cites W1481698833 @default.
- W2800973282 cites W1486135496 @default.
- W2800973282 cites W1486610254 @default.
- W2800973282 cites W1534698434 @default.
- W2800973282 cites W1550904083 @default.
- W2800973282 cites W1573058105 @default.
- W2800973282 cites W1575744217 @default.
- W2800973282 cites W1591802672 @default.
- W2800973282 cites W1610318839 @default.
- W2800973282 cites W1766380752 @default.
- W2800973282 cites W1780156870 @default.
- W2800973282 cites W1786577940 @default.
- W2800973282 cites W1802486171 @default.
- W2800973282 cites W1877026449 @default.
- W2800973282 cites W1884407889 @default.
- W2800973282 cites W1939911045 @default.
- W2800973282 cites W1947323845 @default.
- W2800973282 cites W1963921746 @default.
- W2800973282 cites W1965332062 @default.
- W2800973282 cites W1965853158 @default.
- W2800973282 cites W1965930990 @default.
- W2800973282 cites W1966386635 @default.
- W2800973282 cites W1967099953 @default.
- W2800973282 cites W1967422373 @default.
- W2800973282 cites W1967483524 @default.
- W2800973282 cites W1971016768 @default.
- W2800973282 cites W1976649606 @default.
- W2800973282 cites W1977540067 @default.
- W2800973282 cites W1980381654 @default.
- W2800973282 cites W1980492221 @default.
- W2800973282 cites W1982048806 @default.
- W2800973282 cites W1983353121 @default.
- W2800973282 cites W1984272180 @default.
- W2800973282 cites W1988880364 @default.
- W2800973282 cites W1988923627 @default.
- W2800973282 cites W1989606632 @default.
- W2800973282 cites W1993866135 @default.
- W2800973282 cites W1994014613 @default.
- W2800973282 cites W1995889616 @default.
- W2800973282 cites W1996039824 @default.
- W2800973282 cites W1996577630 @default.
- W2800973282 cites W1996624679 @default.
- W2800973282 cites W2000628551 @default.
- W2800973282 cites W2000685887 @default.
- W2800973282 cites W2001499411 @default.
- W2800973282 cites W2001701627 @default.
- W2800973282 cites W2002209113 @default.
- W2800973282 cites W2003703545 @default.
- W2800973282 cites W2004801056 @default.
- W2800973282 cites W2008077687 @default.
- W2800973282 cites W2008139174 @default.
- W2800973282 cites W2011276676 @default.
- W2800973282 cites W2015177277 @default.
- W2800973282 cites W2020986313 @default.
- W2800973282 cites W2021607498 @default.
- W2800973282 cites W2025919734 @default.
- W2800973282 cites W2026985136 @default.
- W2800973282 cites W2027629550 @default.
- W2800973282 cites W2028511978 @default.
- W2800973282 cites W2030793312 @default.
- W2800973282 cites W2033956931 @default.
- W2800973282 cites W2034599800 @default.
- W2800973282 cites W2034938962 @default.
- W2800973282 cites W2035066532 @default.
- W2800973282 cites W2042371437 @default.
- W2800973282 cites W2043038437 @default.
- W2800973282 cites W2044105851 @default.
- W2800973282 cites W2045046895 @default.
- W2800973282 cites W2046503396 @default.
- W2800973282 cites W2047673356 @default.
- W2800973282 cites W2048702747 @default.
- W2800973282 cites W2049117477 @default.
- W2800973282 cites W2050008018 @default.
- W2800973282 cites W2050289674 @default.
- W2800973282 cites W2050836840 @default.
- W2800973282 cites W2051285904 @default.
- W2800973282 cites W2052616068 @default.
- W2800973282 cites W2053436021 @default.
- W2800973282 cites W2053478490 @default.
- W2800973282 cites W2054390726 @default.
- W2800973282 cites W2060430727 @default.
- W2800973282 cites W2061886027 @default.
- W2800973282 cites W2062061471 @default.
- W2800973282 cites W2062350341 @default.
- W2800973282 cites W2064522481 @default.
- W2800973282 cites W2065259435 @default.
- W2800973282 cites W2066507549 @default.
- W2800973282 cites W2076983187 @default.
- W2800973282 cites W2078307917 @default.
- W2800973282 cites W2079712983 @default.
- W2800973282 cites W2080388275 @default.