FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800977389> ?p ?o ?g. }

• W2800977389 endingPage "17" @default.
• W2800977389 startingPage "9" @default.
• W2800977389 abstract "Follicular-patterned tumors of the thyroid gland are characterized by a predominantly follicular growth pattern. They frequently harbor RAS mutations, not BRAF mutations. Technological advances in molecular testing have discovered novel RAS-type mutations. However, clinical significance of these mutations remains unknown. We investigated the prevalence and clinical impact of mutations of BRAF, NRAS, HRAS, KRAS, EZH1, EIF1AX, and TERT genes by Sanger sequencing in a series of 201 follicular-patterned thyroid tumors including follicular adenoma (n = 40), Hürthle cell adenoma (n = 54), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (n = 50), follicular thyroid carcinoma (n = 40), Hürthle cell carcinoma (n = 10), and poorly differentiated thyroid carcinoma arising in a well-differentiated follicular neoplasm (n = 7), and 120 classic papillary carcinoma. Two hotspots of EZH1 mutations were only found in RAS-negative follicular-patterned tumors. EZH1 mutations were detected in 3% of follicular adenoma and in 20% of Hürthle cell adenoma, and one minimally invasive Hürthle cell carcinoma. Thyroid tumors with EZH1 mutations reported in the literature were benign in most cases. Otherwise, they were minimally invasive or noninvasive cancer. EIF1AX mutation was found in one follicular adenoma. We confirmed the presence of RAS mutations and BRAF K601E mutation in benign, borderline, and malignant follicular-patterned tumors. No BRAF V600E was found in all follicular-patterned tumors. This study also confirmed the occurrence of TERT promoter mutations in high-risk thyroid cancers. These genetic markers can be used for the diagnostic purpose and risk stratification of thyroid nodules." @default.
• W2800977389 created "2018-05-17" @default.
• W2800977389 creator A5017460777 @default.
• W2800977389 creator A5033998540 @default.
• W2800977389 creator A5036684599 @default.
• W2800977389 creator A5083975513 @default.
• W2800977389 creator A5084694805 @default.
• W2800977389 creator A5086531855 @default.
• W2800977389 date "2018-11-01" @default.
• W2800977389 modified "2023-10-18" @default.
• W2800977389 title "Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors" @default.
• W2800977389 cites W1601694353 @default.
• W2800977389 cites W1848939527 @default.
• W2800977389 cites W2018051857 @default.
• W2800977389 cites W2024405748 @default.
• W2800977389 cites W2025856640 @default.
• W2800977389 cites W2073433320 @default.
• W2800977389 cites W2089335658 @default.
• W2800977389 cites W2090842981 @default.
• W2800977389 cites W2104500293 @default.
• W2800977389 cites W2114843025 @default.
• W2800977389 cites W2116318886 @default.
• W2800977389 cites W2149441684 @default.
• W2800977389 cites W2155990718 @default.
• W2800977389 cites W2225849677 @default.
• W2800977389 cites W2289997967 @default.
• W2800977389 cites W2296729886 @default.
• W2800977389 cites W2337882641 @default.
• W2800977389 cites W2464533313 @default.
• W2800977389 cites W2478132860 @default.
• W2800977389 cites W2500338424 @default.
• W2800977389 cites W2510202098 @default.
• W2800977389 cites W2511711677 @default.
• W2800977389 cites W2592003306 @default.
• W2800977389 cites W2626079316 @default.
• W2800977389 cites W2766419069 @default.
• W2800977389 cites W2766668340 @default.
• W2800977389 cites W2793080237 @default.
• W2800977389 doi "https://doi.org/10.1016/j.humpath.2018.04.018" @default.
• W2800977389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29723601" @default.
• W2800977389 hasPublicationYear "2018" @default.
• W2800977389 type Work @default.
• W2800977389 sameAs 2800977389 @default.
• W2800977389 citedByCount "39" @default.
• W2800977389 countsByYear W28009773892018 @default.
• W2800977389 countsByYear W28009773892019 @default.
• W2800977389 countsByYear W28009773892020 @default.
• W2800977389 countsByYear W28009773892021 @default.
• W2800977389 countsByYear W28009773892022 @default.
• W2800977389 countsByYear W28009773892023 @default.
• W2800977389 crossrefType "journal-article" @default.
• W2800977389 hasAuthorship W2800977389A5017460777 @default.
• W2800977389 hasAuthorship W2800977389A5033998540 @default.
• W2800977389 hasAuthorship W2800977389A5036684599 @default.
• W2800977389 hasAuthorship W2800977389A5083975513 @default.
• W2800977389 hasAuthorship W2800977389A5084694805 @default.
• W2800977389 hasAuthorship W2800977389A5086531855 @default.
• W2800977389 hasBestOaLocation W28009773891 @default.
• W2800977389 hasConcept C1167327 @default.
• W2800977389 hasConcept C121608353 @default.
• W2800977389 hasConcept C126322002 @default.
• W2800977389 hasConcept C142724271 @default.
• W2800977389 hasConcept C187785154 @default.
• W2800977389 hasConcept C21790070 @default.
• W2800977389 hasConcept C2777428134 @default.
• W2800977389 hasConcept C2778057883 @default.
• W2800977389 hasConcept C2779022025 @default.
• W2800977389 hasConcept C2779761222 @default.
• W2800977389 hasConcept C2781187634 @default.
• W2800977389 hasConcept C2993294228 @default.
• W2800977389 hasConcept C502942594 @default.
• W2800977389 hasConcept C526584372 @default.
• W2800977389 hasConcept C526805850 @default.
• W2800977389 hasConcept C71924100 @default.
• W2800977389 hasConcept C86803240 @default.
• W2800977389 hasConceptScore W2800977389C1167327 @default.
• W2800977389 hasConceptScore W2800977389C121608353 @default.
• W2800977389 hasConceptScore W2800977389C126322002 @default.
• W2800977389 hasConceptScore W2800977389C142724271 @default.
• W2800977389 hasConceptScore W2800977389C187785154 @default.
• W2800977389 hasConceptScore W2800977389C21790070 @default.
• W2800977389 hasConceptScore W2800977389C2777428134 @default.
• W2800977389 hasConceptScore W2800977389C2778057883 @default.
• W2800977389 hasConceptScore W2800977389C2779022025 @default.
• W2800977389 hasConceptScore W2800977389C2779761222 @default.
• W2800977389 hasConceptScore W2800977389C2781187634 @default.
• W2800977389 hasConceptScore W2800977389C2993294228 @default.
• W2800977389 hasConceptScore W2800977389C502942594 @default.
• W2800977389 hasConceptScore W2800977389C526584372 @default.
• W2800977389 hasConceptScore W2800977389C526805850 @default.
• W2800977389 hasConceptScore W2800977389C71924100 @default.
• W2800977389 hasConceptScore W2800977389C86803240 @default.
• W2800977389 hasFunder F4320322034 @default.
• W2800977389 hasLocation W28009773891 @default.
• W2800977389 hasLocation W28009773892 @default.
• W2800977389 hasOpenAccess W2800977389 @default.
• W2800977389 hasPrimaryLocation W28009773891 @default.
• W2800977389 hasRelatedWork W1746007799 @default.

• next