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• W2801003738 abstract "Summary Infections caused by Rasamsonia argillacea complex have been reported in various clinical settings. Cystic fibrosis ( CF ) is one of the main underlying conditions. An observational cohort study of CF patients with Rasamsonia in respiratory samples was conducted. Eight isolates from 6 patients were identified as R. argillacea complex and tested for antifungal susceptibility. All isolates had high MIC s to voriconazole and posaconazole and low MEC s to echinocandins. Four patients experienced lung function decline in the year preceding first Rasamsonia isolation. This continued in the year following first isolation in 3 out of 4 cases. Antifungal therapy was initiated in 2 patients, to which only one exhibited a clinical response. Three out of 6 patients died within 3 years of isolating Rasamsonia . Genotyping suggests that similar genotypes of Rasamsonia can persist in CF airways. Consistent with other fungi in CF , the clinical impact of airway colonisation by Rasamsonia is variable. In certain patients, Rasamsonia may be able to drive clinical decline. In others, though a clear impact on lung function may be difficult to determine, the appearance of Rasamsonia acts as a marker of disease severity. In others it does not appear to have an obvious clinical impact on disease progression." @default.
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• W2801003738 date "2018-06-20" @default.
• W2801003738 modified "2023-10-18" @default.
• W2801003738 title "Airway persistence by the emerging multi-azole-resistant <i>Rasamsonia argillacea</i> complex in cystic fibrosis" @default.
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• W2801003738 doi "https://doi.org/10.1111/myc.12789" @default.
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