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- W2801005687 abstract "To assess biological variation of troponin T in emergency settings and establish limits for interpretation of serial results.We studied 6,557 consecutive patients with troponin measurements. A stable reference subset was selected to estimate biological variation and threshold limits.The first troponin level was elevated in 32% of patients, and 2,490 had a second troponin level with a myocardial infarction (MI) prevalence of 16.2%. In the stable reference group with at least one abnormal value, the 99th percentile of the absolute delta between the first two samples was 16 ng/L. For MI diagnosis, the area under the receiver operating characteristic curve was 0.85 (confidence interval [CI], 0.83-0.87) for the first troponin level and 0.94 (CI, 0.93-0.95) for the absolute delta.An absolute delta of 16 ng/L has good specificity in the emergency setting. This threshold is valid for any sex, age, and sampling interval between 3 and 24 hours and is higher than published limits found in healthy outpatients." @default.
- W2801005687 created "2018-05-17" @default.
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- W2801005687 date "2018-04-28" @default.
- W2801005687 modified "2023-10-14" @default.
- W2801005687 title "Variability of High-Sensitivity Troponin T Concentrations in Emergency Settings" @default.
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- W2801005687 doi "https://doi.org/10.1093/ajcp/aqy025" @default.
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