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- W2801018659 abstract "Azoospermia, oligospermia and teratozoospermia all seriously impact male reproductive health. Spermatogenesis is a complex and precisely regulated process in which germ cells proliferate and differentiate and involves the regulation of multiple testis-specific genes. Here, we identified testis-specific gene spermatogenesis-associated 48 (SPATA48), the expression of which was age-dependent, indicating that it is involved in spermatogenesis. In humans and mice with azoospermia, expression of SPATA48 disappeared in the testis. Spata48−/− knockout male mice had smaller testis and defective spermatogenesis compared to wild-type (WT) mice. This study can help in the exploration of the genetic basis of male infertility and identify new targets for the diagnosis and treatment of male infertility." @default.
- W2801018659 created "2018-05-17" @default.
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- W2801018659 date "2018-04-26" @default.
- W2801018659 modified "2023-10-15" @default.
- W2801018659 title "<i>Spermatogenesis-associated 48</i>is essential for spermatogenesis in mice" @default.
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- W2801018659 doi "https://doi.org/10.1111/and.13027" @default.
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