Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801023552> ?p ?o ?g. }
- W2801023552 endingPage "5625" @default.
- W2801023552 startingPage "5615" @default.
- W2801023552 abstract "Ag+ ions are a well-known antibacterial agent, and Ag nanoparticles act as a reservoir of these Ag+ ions for targeted therapy of bacterial infections. However, there are no tools to effectively trigger and monitor the release of Ag+ ions from Ag nanoparticles. Photoacoustic (PA) imaging is an emerging noninvasive imaging tool, and gold nanorods (AuNRs) are an excellent contrast agent for PA imaging. In this work, we developed Au/Ag hybrid nanoparticles by coating AuNRs with silver (Ag), which decreased their photoacoustic signal. The as-prepared, Ag-coated Au nanorods (Au/AgNRs) are stable under ambient conditions, but the addition of ferricyanide solution (1 mM) results in oxidative etching of the silver shell. The PA contrast is simultaneously recovered as the silver is released, and this PA signal offers noninvasive monitoring of localized release of Ag+ ions. The released Ag+ ions exhibit a strong bactericidal efficacy similar to equivalent free Ag+ ions (AgNO3), and the nanoparticles killed >99.99% of both (Gram-positive) methicillin-resistant Staphylococcus aureus (MRSA, 32 μM Ag+ equivalent) and (Gram-negative) Escherichia coli (8 μM Ag+ equivalent). The theranostic potential of these nanoparticles was demonstrated in a pilot in vivo study. Mice were inoculated with MRSA and Au/AgNRs were subcutaneously implanted followed by silver etching. There was a 730% increase in the PA signal (p < 0.01) pre- and post-etching, and the bacterial counts in infected tissues of the treated group were reduced by 1000-fold (log CFU/g = 4.15 vs 7.75) versus the untreated control; this treatment efficacy was confirmed with histology. We further showed that these hybrid nanoparticles could release Ag+ after stimulation by reactive oxygen species including hydrogen peroxide and peroxynitrite. These hybrid Au/Ag nanoparticles are a useful theranostic agent for the photoacoustic imaging and treatment of bacterial infections." @default.
- W2801023552 created "2018-05-17" @default.
- W2801023552 creator A5002540920 @default.
- W2801023552 creator A5003014116 @default.
- W2801023552 creator A5029636776 @default.
- W2801023552 creator A5041432744 @default.
- W2801023552 creator A5083005519 @default.
- W2801023552 date "2018-05-10" @default.
- W2801023552 modified "2023-10-13" @default.
- W2801023552 title "A Gold/Silver Hybrid Nanoparticle for Treatment and Photoacoustic Imaging of Bacterial Infection" @default.
- W2801023552 cites W1969471545 @default.
- W2801023552 cites W1970412285 @default.
- W2801023552 cites W1975100554 @default.
- W2801023552 cites W1976538675 @default.
- W2801023552 cites W1978369328 @default.
- W2801023552 cites W1978695076 @default.
- W2801023552 cites W1980921853 @default.
- W2801023552 cites W1981224435 @default.
- W2801023552 cites W1990189624 @default.
- W2801023552 cites W1993548586 @default.
- W2801023552 cites W1999770429 @default.
- W2801023552 cites W2004802404 @default.
- W2801023552 cites W2010144147 @default.
- W2801023552 cites W2011272615 @default.
- W2801023552 cites W2013322023 @default.
- W2801023552 cites W2014358738 @default.
- W2801023552 cites W2019319795 @default.
- W2801023552 cites W2022849239 @default.
- W2801023552 cites W2024175318 @default.
- W2801023552 cites W2034036690 @default.
- W2801023552 cites W2037263743 @default.
- W2801023552 cites W2040854487 @default.
- W2801023552 cites W2041481741 @default.
- W2801023552 cites W2045987764 @default.
- W2801023552 cites W2046306695 @default.
- W2801023552 cites W2054486620 @default.
- W2801023552 cites W2061073363 @default.
- W2801023552 cites W2065294001 @default.
- W2801023552 cites W2067203318 @default.
- W2801023552 cites W2067858257 @default.
- W2801023552 cites W2068805676 @default.
- W2801023552 cites W2068926508 @default.
- W2801023552 cites W2069832552 @default.
- W2801023552 cites W2073985842 @default.
- W2801023552 cites W2074245293 @default.
- W2801023552 cites W2075512377 @default.
- W2801023552 cites W2077768338 @default.
- W2801023552 cites W2080376276 @default.
- W2801023552 cites W2084570604 @default.
- W2801023552 cites W2086984478 @default.
- W2801023552 cites W2089149190 @default.
- W2801023552 cites W2089403444 @default.
- W2801023552 cites W2089901886 @default.
- W2801023552 cites W2093502875 @default.
- W2801023552 cites W2094005944 @default.
- W2801023552 cites W2096097264 @default.
- W2801023552 cites W2099039284 @default.
- W2801023552 cites W2099540110 @default.
- W2801023552 cites W2114809075 @default.
- W2801023552 cites W2117735972 @default.
- W2801023552 cites W2137138484 @default.
- W2801023552 cites W2139221049 @default.
- W2801023552 cites W2142343447 @default.
- W2801023552 cites W2145789959 @default.
- W2801023552 cites W2147993424 @default.
- W2801023552 cites W2157355169 @default.
- W2801023552 cites W2165954391 @default.
- W2801023552 cites W2166712052 @default.
- W2801023552 cites W2168632854 @default.
- W2801023552 cites W2170646793 @default.
- W2801023552 cites W2264664749 @default.
- W2801023552 cites W2293968320 @default.
- W2801023552 cites W2312794820 @default.
- W2801023552 cites W2320552914 @default.
- W2801023552 cites W2321384837 @default.
- W2801023552 cites W2325712626 @default.
- W2801023552 cites W2420216801 @default.
- W2801023552 cites W2484448248 @default.
- W2801023552 cites W2517872912 @default.
- W2801023552 cites W2526566865 @default.
- W2801023552 cites W2538692849 @default.
- W2801023552 cites W2553807524 @default.
- W2801023552 cites W2559352429 @default.
- W2801023552 cites W2593763693 @default.
- W2801023552 cites W2599117579 @default.
- W2801023552 cites W2610020367 @default.
- W2801023552 cites W2613194685 @default.
- W2801023552 cites W2621940244 @default.
- W2801023552 cites W2734456297 @default.
- W2801023552 cites W2741102371 @default.
- W2801023552 cites W2746188371 @default.
- W2801023552 cites W2750939010 @default.
- W2801023552 cites W2760971081 @default.
- W2801023552 cites W2764175698 @default.
- W2801023552 cites W2767787247 @default.
- W2801023552 cites W3104251514 @default.
- W2801023552 doi "https://doi.org/10.1021/acsnano.8b01362" @default.
- W2801023552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8045556" @default.