Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801031128> ?p ?o ?g. }
- W2801031128 endingPage "64" @default.
- W2801031128 startingPage "18" @default.
- W2801031128 abstract "Abstract Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes. Currently, there are more than 10 known classes of ZFs, with various architectures, metal binding modes, functions and reactivity. The versatility, selectivity and stability of these short amino acid sequences is achieved mainly by (i) residues participating in Zn(II) coordination (mostly Cys and His), (ii) hydrophobic core and ZF structure formation, and (iii) variable residues responsible for inter- and intramolecular interactions. Since their discovery, ZFs have been extensively studied in terms of their structure, stability and recognition targets by the application of various methodologies. Studies based on interactions with other metal ions and their complexes have contributed to the understanding of their chemical properties and the discovery of new types of ZF complexes, such as gold fingers or lead fingers. Moreover, due to the presence of nucleophilic thiolates, ZFs are targets for reactive oxygen and nitrogen species as well as alkylating agents. Interactions with many reactive molecules lead to disturb the native Zn(II) coordination site which further result in structural and functional damage of the ZFs. The post-translational modifications including phosphorylation, acetylation, methylation or nitrosylation frequently affect ZFs function via changes in the protein structure and dynamics. Even though the literature is replete with structural and stability data regarding classical (ββα) ZFs, there is still a huge gap in the knowledge on physicochemical properties and reactivity of other ZF types. In this review, metal binding properties of ZFs and stability factors that modulate their functions are reviewed. These include interactions of ZFs with biogenic and toxic metal ions as well as damage occurring upon reaction with reactive oxygen and nitrogen species, the methodology used for ZFs characterization, and aspects related to coordination chemistry." @default.
- W2801031128 created "2018-05-17" @default.
- W2801031128 creator A5040649064 @default.
- W2801031128 creator A5081178130 @default.
- W2801031128 creator A5084434977 @default.
- W2801031128 date "2018-07-01" @default.
- W2801031128 modified "2023-10-17" @default.
- W2801031128 title "Metal binding properties, stability and reactivity of zinc fingers" @default.
- W2801031128 cites W106673314 @default.
- W2801031128 cites W1479713319 @default.
- W2801031128 cites W1485670237 @default.
- W2801031128 cites W1507690786 @default.
- W2801031128 cites W1510974900 @default.
- W2801031128 cites W1512639331 @default.
- W2801031128 cites W1519226646 @default.
- W2801031128 cites W1527762941 @default.
- W2801031128 cites W1531234455 @default.
- W2801031128 cites W1536053852 @default.
- W2801031128 cites W1539177644 @default.
- W2801031128 cites W1547975753 @default.
- W2801031128 cites W1563674780 @default.
- W2801031128 cites W1567332957 @default.
- W2801031128 cites W1574905542 @default.
- W2801031128 cites W1598460752 @default.
- W2801031128 cites W1605692660 @default.
- W2801031128 cites W1648597485 @default.
- W2801031128 cites W1685907241 @default.
- W2801031128 cites W1734082729 @default.
- W2801031128 cites W1780544763 @default.
- W2801031128 cites W1786145381 @default.
- W2801031128 cites W1824346003 @default.
- W2801031128 cites W1846323380 @default.
- W2801031128 cites W1895731059 @default.
- W2801031128 cites W1914804546 @default.
- W2801031128 cites W1928629620 @default.
- W2801031128 cites W1948061557 @default.
- W2801031128 cites W1954690293 @default.
- W2801031128 cites W1963926671 @default.
- W2801031128 cites W1964760602 @default.
- W2801031128 cites W1965398400 @default.
- W2801031128 cites W1965879055 @default.
- W2801031128 cites W1966807078 @default.
- W2801031128 cites W1967023837 @default.
- W2801031128 cites W1967304731 @default.
- W2801031128 cites W1967598896 @default.
- W2801031128 cites W1969543470 @default.
- W2801031128 cites W1969760979 @default.
- W2801031128 cites W1970559654 @default.
- W2801031128 cites W1971117794 @default.
- W2801031128 cites W1972992920 @default.
- W2801031128 cites W1973297589 @default.
- W2801031128 cites W1974830912 @default.
- W2801031128 cites W1975311638 @default.
- W2801031128 cites W1975692560 @default.
- W2801031128 cites W1975780956 @default.
- W2801031128 cites W1975957991 @default.
- W2801031128 cites W1976394361 @default.
- W2801031128 cites W1976459530 @default.
- W2801031128 cites W1976483021 @default.
- W2801031128 cites W1976638583 @default.
- W2801031128 cites W1977162123 @default.
- W2801031128 cites W1977273560 @default.
- W2801031128 cites W1977587496 @default.
- W2801031128 cites W1978028485 @default.
- W2801031128 cites W1978130680 @default.
- W2801031128 cites W1978298108 @default.
- W2801031128 cites W1979013338 @default.
- W2801031128 cites W1979100273 @default.
- W2801031128 cites W1981026057 @default.
- W2801031128 cites W1981887436 @default.
- W2801031128 cites W1983231450 @default.
- W2801031128 cites W1983345703 @default.
- W2801031128 cites W1983566654 @default.
- W2801031128 cites W1983883288 @default.
- W2801031128 cites W1983981760 @default.
- W2801031128 cites W1984122552 @default.
- W2801031128 cites W1984733240 @default.
- W2801031128 cites W1985467496 @default.
- W2801031128 cites W1986093310 @default.
- W2801031128 cites W1986171863 @default.
- W2801031128 cites W1986627314 @default.
- W2801031128 cites W1986938385 @default.
- W2801031128 cites W1987054630 @default.
- W2801031128 cites W1987677301 @default.
- W2801031128 cites W1988282349 @default.
- W2801031128 cites W1988354330 @default.
- W2801031128 cites W1989287807 @default.
- W2801031128 cites W1989763857 @default.
- W2801031128 cites W1989987141 @default.
- W2801031128 cites W1990043600 @default.
- W2801031128 cites W1990147235 @default.
- W2801031128 cites W1990563490 @default.
- W2801031128 cites W1990830736 @default.
- W2801031128 cites W1990918750 @default.
- W2801031128 cites W1990988819 @default.
- W2801031128 cites W1991556982 @default.
- W2801031128 cites W1991653374 @default.
- W2801031128 cites W1991748250 @default.