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• W2801036890 abstract "Biological development involves numerous chemical and physical processes which must act in concert to reliably produce a cell, a tissue, or a body. To be successful, the developing organism must be robust to variability at many levels, such as the environment (e.g. temperature, moisture), upstream information (such as long-range positional information gradients), or intrinsic noise due to the stochastic nature of low concentration chemical kinetics. The latter is especially relevant to the regulation of gene expression in cell differentiation. The temporal stochasticity of gene expression has been studied in single celled organisms for nearly two decades, but only recently have techniques become available to gather temporally-resolved data across spatially-distributed gene expression patterns in developing multicellular organisms. These demonstrate temporal noisy ‘bursting’ in the number of gene transcripts per cell, raising the question of how the transcript number defining a particular cell type is produced, such that one cell type can reliably be distinguished from a neighbouring cell of different type along a tissue boundary. Stochastic spatio-temporal modelling of tissue-wide expression patterns can identify signatures for specific types of gene regulation, which can be used to extract regulatory mechanism information from experimental time series. This Perspective focuses on using this type of approach to study gene expression noise during the anterior-posterior segmentation of the fruit fly embryo. Advances in experimental and theoretical techniques will lead to an increasing quantification of expression noise that can be used to understand how regulatory mechanisms contribute to embryonic robustness across a range of developmental processes." @default.
• W2801036890 created "2018-05-17" @default.
• W2801036890 creator A5024247574 @default.
• W2801036890 date "2018-04-18" @default.
• W2801036890 modified "2023-10-18" @default.
• W2801036890 title "Experimental and Modeling Approaches for Understanding the Effect of Gene Expression Noise in Biological Development" @default.
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• W2801036890 doi "https://doi.org/10.3389/fphy.2018.00036" @default.
• W2801036890 hasPublicationYear "2018" @default.
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