Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801039670> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2801039670 endingPage "23" @default.
- W2801039670 startingPage "15" @default.
- W2801039670 abstract "Previously designated a comfortable and effective scheme of 3,7-disubstituted [1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones synthesis was spread to derivatives of ω-(7-aryl-8-oxo-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl) alkylcarboxylic acids. Our approach consists of application of reaction of formerly described 3-hydrazinopyrazin-2-ones with cyclic anhydrides of dicarbonic acids such as succinic and glutaric anhydrides. Consequent cyclization was carried out in DMFA by means of boiling during 12 hours and resulted in creation of 3-(7-aryl-8-oxo-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl)propanoic acids or 4-(7-aryl-8-oxo-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl) butanoic acids with yield 51 – 65%. To obtain amides we used activation of carboxylic group of obtained acids by means of application of carbonilmidiimidazolamide along with anhydrous dioxane with intermidiate creation of imidazolilamide, subsequent reaction with both of aliphatic and aromatic amines was carried out by means of boiling for 12 hours. Yield of obtained amides was approxiametely 50 – 92%. The structure of obtained compounds was proved by means of elemental analysis and 1H NMR spectroscopy data. The synthesized compounds are of certain interest as potential pharmacologic agents associated with the regulation of lipid metabolism and ability of these compounds to have an impact on the level of lipoproteins, purine metabolism and receptivity of tissues to glucose." @default.
- W2801039670 created "2018-05-17" @default.
- W2801039670 creator A5019804037 @default.
- W2801039670 creator A5065363552 @default.
- W2801039670 creator A5068886793 @default.
- W2801039670 creator A5070201675 @default.
- W2801039670 creator A5074576875 @default.
- W2801039670 creator A5090840706 @default.
- W2801039670 date "2016-06-13" @default.
- W2801039670 modified "2023-10-18" @default.
- W2801039670 title "Synthesis of ω-(7-aryl-8-oxo-7,8-dihydro[1,2,4]-triazolo-[4,3-a]pyrazin-3-yl)alkylcarboxylic acids and their amides as perspective pharmaceutical agents" @default.
- W2801039670 doi "https://doi.org/10.24959/nphj.16.2095" @default.
- W2801039670 hasPublicationYear "2016" @default.
- W2801039670 type Work @default.
- W2801039670 sameAs 2801039670 @default.
- W2801039670 citedByCount "0" @default.
- W2801039670 crossrefType "journal-article" @default.
- W2801039670 hasAuthorship W2801039670A5019804037 @default.
- W2801039670 hasAuthorship W2801039670A5065363552 @default.
- W2801039670 hasAuthorship W2801039670A5068886793 @default.
- W2801039670 hasAuthorship W2801039670A5070201675 @default.
- W2801039670 hasAuthorship W2801039670A5074576875 @default.
- W2801039670 hasAuthorship W2801039670A5090840706 @default.
- W2801039670 hasBestOaLocation W28010396701 @default.
- W2801039670 hasConcept C134121241 @default.
- W2801039670 hasConcept C155647269 @default.
- W2801039670 hasConcept C178790620 @default.
- W2801039670 hasConcept C185592680 @default.
- W2801039670 hasConcept C187714232 @default.
- W2801039670 hasConcept C191897082 @default.
- W2801039670 hasConcept C192562407 @default.
- W2801039670 hasConcept C2777765701 @default.
- W2801039670 hasConcept C2779761105 @default.
- W2801039670 hasConcept C2780263894 @default.
- W2801039670 hasConcept C2781076698 @default.
- W2801039670 hasConcept C71240020 @default.
- W2801039670 hasConceptScore W2801039670C134121241 @default.
- W2801039670 hasConceptScore W2801039670C155647269 @default.
- W2801039670 hasConceptScore W2801039670C178790620 @default.
- W2801039670 hasConceptScore W2801039670C185592680 @default.
- W2801039670 hasConceptScore W2801039670C187714232 @default.
- W2801039670 hasConceptScore W2801039670C191897082 @default.
- W2801039670 hasConceptScore W2801039670C192562407 @default.
- W2801039670 hasConceptScore W2801039670C2777765701 @default.
- W2801039670 hasConceptScore W2801039670C2779761105 @default.
- W2801039670 hasConceptScore W2801039670C2780263894 @default.
- W2801039670 hasConceptScore W2801039670C2781076698 @default.
- W2801039670 hasConceptScore W2801039670C71240020 @default.
- W2801039670 hasIssue "2(86)" @default.
- W2801039670 hasLocation W28010396701 @default.
- W2801039670 hasOpenAccess W2801039670 @default.
- W2801039670 hasPrimaryLocation W28010396701 @default.
- W2801039670 hasRelatedWork W2097014657 @default.
- W2801039670 hasRelatedWork W2177648009 @default.
- W2801039670 hasRelatedWork W2324898221 @default.
- W2801039670 hasRelatedWork W2332664307 @default.
- W2801039670 hasRelatedWork W2360485851 @default.
- W2801039670 hasRelatedWork W2949739074 @default.
- W2801039670 hasRelatedWork W2950314565 @default.
- W2801039670 hasRelatedWork W2951479270 @default.
- W2801039670 hasRelatedWork W2951951660 @default.
- W2801039670 hasRelatedWork W2998388781 @default.
- W2801039670 hasVolume "0" @default.
- W2801039670 isParatext "false" @default.
- W2801039670 isRetracted "false" @default.
- W2801039670 magId "2801039670" @default.
- W2801039670 workType "article" @default.