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- W2801043350 endingPage "994" @default.
- W2801043350 startingPage "975" @default.
- W2801043350 abstract "Abstract Multipotent progenitor cells present in adult tissues are generally referred to as mesenchymal stem cells (MSCs). MSCs are believed to function in the replacement of damaged or dead somatic cells and thus play a critical role in maintaining body structure and homeostasis. Because of their multilineage differentiation capacity, immunomodulation potential, and trophic factor-producing ability, there have been active attempts toward clinical application of MSCs to treat a variety of tissue-based and systemic diseases. However, the availability and function of MSCs are compromised with host aging. In addition, therapeutic success generally requires a sufficient number of cells, and in vitro expansion is generally necessary, often resulting in artifactual replicative senescence and functional alterations. In this chapter, we first review current progress in the characterization of human MSC aging, both in vivo and in vitro, its mechanistic basis, and the effect of aging on MSC-based therapy. We also discuss the potential strategy in slowing, stopping, or even reversing MSC aging, for the purpose of augmentation of their clinical utility." @default.
- W2801043350 created "2018-05-17" @default.
- W2801043350 creator A5023015562 @default.
- W2801043350 creator A5043189123 @default.
- W2801043350 creator A5057499766 @default.
- W2801043350 date "2018-01-01" @default.
- W2801043350 modified "2023-10-14" @default.
- W2801043350 title "Aging of Human Mesenchymal Stem Cells" @default.
- W2801043350 cites W128190313 @default.
- W2801043350 cites W1502442150 @default.
- W2801043350 cites W1530824105 @default.
- W2801043350 cites W1566246481 @default.
- W2801043350 cites W1568003817 @default.
- W2801043350 cites W1599167370 @default.
- W2801043350 cites W1656929032 @default.
- W2801043350 cites W1660392447 @default.
- W2801043350 cites W1741528858 @default.
- W2801043350 cites W1804670053 @default.
- W2801043350 cites W1871911223 @default.
- W2801043350 cites W1967169606 @default.
- W2801043350 cites W1967412255 @default.
- W2801043350 cites W1969118281 @default.
- W2801043350 cites W1971791040 @default.
- W2801043350 cites W1973274665 @default.
- W2801043350 cites W1974033361 @default.
- W2801043350 cites W1975712445 @default.
- W2801043350 cites W1977567827 @default.
- W2801043350 cites W1977641825 @default.
- W2801043350 cites W1978174791 @default.
- W2801043350 cites W1978269248 @default.
- W2801043350 cites W1978702852 @default.
- W2801043350 cites W1978846261 @default.
- W2801043350 cites W1978993910 @default.
- W2801043350 cites W1981222696 @default.
- W2801043350 cites W1981377319 @default.
- W2801043350 cites W1982323513 @default.
- W2801043350 cites W1982395176 @default.
- W2801043350 cites W1982408656 @default.
- W2801043350 cites W1983594275 @default.
- W2801043350 cites W1983673827 @default.
- W2801043350 cites W1984505531 @default.
- W2801043350 cites W1986224715 @default.
- W2801043350 cites W1987966591 @default.
- W2801043350 cites W1990423201 @default.
- W2801043350 cites W1991554693 @default.
- W2801043350 cites W1992786647 @default.
- W2801043350 cites W1993693761 @default.
- W2801043350 cites W1998461585 @default.
- W2801043350 cites W1999967032 @default.
- W2801043350 cites W2002179012 @default.
- W2801043350 cites W2002846959 @default.
- W2801043350 cites W2007194140 @default.
- W2801043350 cites W2008612463 @default.
- W2801043350 cites W2011058197 @default.
- W2801043350 cites W2011482325 @default.
- W2801043350 cites W2011572299 @default.
- W2801043350 cites W2013287222 @default.
- W2801043350 cites W2014673628 @default.
- W2801043350 cites W2015544059 @default.
- W2801043350 cites W2024971445 @default.
- W2801043350 cites W2025371271 @default.
- W2801043350 cites W2025803508 @default.
- W2801043350 cites W2027069013 @default.
- W2801043350 cites W2027321083 @default.
- W2801043350 cites W2027703054 @default.
- W2801043350 cites W2027755118 @default.
- W2801043350 cites W2029417570 @default.
- W2801043350 cites W2035065708 @default.
- W2801043350 cites W2035176325 @default.
- W2801043350 cites W2035976926 @default.
- W2801043350 cites W2039533211 @default.
- W2801043350 cites W2042000503 @default.
- W2801043350 cites W2043060398 @default.
- W2801043350 cites W2043263890 @default.
- W2801043350 cites W2043529886 @default.
- W2801043350 cites W2044767452 @default.
- W2801043350 cites W2045456080 @default.
- W2801043350 cites W2046357669 @default.
- W2801043350 cites W2046873552 @default.
- W2801043350 cites W2047003816 @default.
- W2801043350 cites W2047330128 @default.
- W2801043350 cites W2049446122 @default.
- W2801043350 cites W2049584490 @default.
- W2801043350 cites W2050018625 @default.
- W2801043350 cites W2058906518 @default.
- W2801043350 cites W2059807701 @default.
- W2801043350 cites W2063048290 @default.
- W2801043350 cites W2064489225 @default.
- W2801043350 cites W2064919073 @default.
- W2801043350 cites W2072807932 @default.
- W2801043350 cites W2073290778 @default.
- W2801043350 cites W2075734310 @default.
- W2801043350 cites W2077126114 @default.
- W2801043350 cites W2077510301 @default.
- W2801043350 cites W2077814461 @default.
- W2801043350 cites W2078653911 @default.
- W2801043350 cites W2079983476 @default.
- W2801043350 cites W2082396938 @default.