Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801047995> ?p ?o ?g. }
- W2801047995 abstract "The ability to adapt to environmental changes is an essential feature of biological systems, achieved in animals by a coordinated crosstalk between neuronal and hormonal programs that allow rapid and integrated organismal responses. Reward systems play a key role in mediating this adaptation by reinforcing behaviors that enhance immediate survival, such as eating or drinking, or those that ensure long-term survival, such as sexual behavior or caring for offspring. Drugs of abuse co-opt neuronal and molecular pathways that mediate natural rewards, which under certain circumstances can lead to addiction. Many factors can contribute to the transition from drug use to drug addiction, highlighting the need to discover mechanisms underlying the progression from initial drug use to drug addiction. Since similar responses to natural and drug rewards are present in very different animals, it is likely that the central systems that process reward stimuli originated early in evolution, and that common ancient biological principles and genes are involved in these processes. Thus, the neurobiology of natural and drug rewards can be studied using simpler model organisms that have their systems stripped of some of the immense complexity that exists in mammalian brains. In this paper we review studies in Drosophila melanogaster that model different aspects of natural and drug rewards, with an emphasis on how motivational states shape the value of the rewarding experience, as an entry point to understanding the mechanisms that contribute to the vulnerability of drug addiction." @default.
- W2801047995 created "2018-05-17" @default.
- W2801047995 creator A5004354936 @default.
- W2801047995 creator A5015524824 @default.
- W2801047995 creator A5049838333 @default.
- W2801047995 creator A5066856920 @default.
- W2801047995 date "2018-04-24" @default.
- W2801047995 modified "2023-10-12" @default.
- W2801047995 title "Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies in Drosophila melanogaster" @default.
- W2801047995 cites W1496199042 @default.
- W2801047995 cites W1511843423 @default.
- W2801047995 cites W1538043847 @default.
- W2801047995 cites W1550358545 @default.
- W2801047995 cites W1585430510 @default.
- W2801047995 cites W1608706110 @default.
- W2801047995 cites W1707647127 @default.
- W2801047995 cites W1736392861 @default.
- W2801047995 cites W1804641217 @default.
- W2801047995 cites W1917872676 @default.
- W2801047995 cites W1919427945 @default.
- W2801047995 cites W1966840718 @default.
- W2801047995 cites W1968147041 @default.
- W2801047995 cites W1969645371 @default.
- W2801047995 cites W1972569657 @default.
- W2801047995 cites W1973667619 @default.
- W2801047995 cites W1976250891 @default.
- W2801047995 cites W1976344568 @default.
- W2801047995 cites W1976797314 @default.
- W2801047995 cites W1977192770 @default.
- W2801047995 cites W1979992706 @default.
- W2801047995 cites W1980993643 @default.
- W2801047995 cites W1981922832 @default.
- W2801047995 cites W1983156044 @default.
- W2801047995 cites W1985843462 @default.
- W2801047995 cites W1986574990 @default.
- W2801047995 cites W1987549408 @default.
- W2801047995 cites W1989621413 @default.
- W2801047995 cites W1989694898 @default.
- W2801047995 cites W1990793698 @default.
- W2801047995 cites W1992355586 @default.
- W2801047995 cites W1994337546 @default.
- W2801047995 cites W1998982008 @default.
- W2801047995 cites W1999352359 @default.
- W2801047995 cites W1999882425 @default.
- W2801047995 cites W1999985543 @default.
- W2801047995 cites W2000071989 @default.
- W2801047995 cites W2000409926 @default.
- W2801047995 cites W2001281439 @default.
- W2801047995 cites W2002379808 @default.
- W2801047995 cites W2003982930 @default.
- W2801047995 cites W2004437322 @default.
- W2801047995 cites W2004650335 @default.
- W2801047995 cites W2006134227 @default.
- W2801047995 cites W2007611402 @default.
- W2801047995 cites W2010842131 @default.
- W2801047995 cites W2011269460 @default.
- W2801047995 cites W2011685750 @default.
- W2801047995 cites W2015707766 @default.
- W2801047995 cites W2017495352 @default.
- W2801047995 cites W2018478615 @default.
- W2801047995 cites W2018929375 @default.
- W2801047995 cites W2019392697 @default.
- W2801047995 cites W2021782736 @default.
- W2801047995 cites W2025253889 @default.
- W2801047995 cites W2025440394 @default.
- W2801047995 cites W2026650454 @default.
- W2801047995 cites W2026992346 @default.
- W2801047995 cites W2028560526 @default.
- W2801047995 cites W2028791709 @default.
- W2801047995 cites W2029573742 @default.
- W2801047995 cites W2030582237 @default.
- W2801047995 cites W2032911818 @default.
- W2801047995 cites W2033574123 @default.
- W2801047995 cites W2033745381 @default.
- W2801047995 cites W2034278075 @default.
- W2801047995 cites W2038090020 @default.
- W2801047995 cites W2038368473 @default.
- W2801047995 cites W2039395215 @default.
- W2801047995 cites W2040751411 @default.
- W2801047995 cites W2040771233 @default.
- W2801047995 cites W2041018266 @default.
- W2801047995 cites W2042875552 @default.
- W2801047995 cites W2043547481 @default.
- W2801047995 cites W2044178731 @default.
- W2801047995 cites W2046903234 @default.
- W2801047995 cites W2047813723 @default.
- W2801047995 cites W2048909427 @default.
- W2801047995 cites W2049121574 @default.
- W2801047995 cites W2050541410 @default.
- W2801047995 cites W2053153183 @default.
- W2801047995 cites W2053384937 @default.
- W2801047995 cites W2053807193 @default.
- W2801047995 cites W2054944848 @default.
- W2801047995 cites W2055239456 @default.
- W2801047995 cites W2060496335 @default.
- W2801047995 cites W2061161259 @default.
- W2801047995 cites W2063287091 @default.
- W2801047995 cites W2065995188 @default.
- W2801047995 cites W2066848874 @default.
- W2801047995 cites W2071096427 @default.