FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801061298> ?p ?o ?g. }

• W2801061298 abstract "The relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like Transcription Factor (HLTF) is a tumor suppressor, altered in cancer either by gene hypermethylation or mRNA alternative splicing. This study assessed the expression and the clinical relevance of wild-type (WT) and variant forms of HLTF RNAs in NSCLC. We analyzed online databases (TCGA, COSMIC) for HLTF alterations in NSCLC and assessed WT and spliced HLTF mRNAs expression by RT-ddPCR in 39 lung cancer cell lines and 171 patients with resected stage I-II NSCLC. In silico analyses identified HLTF gene alterations more frequently in lung squamous cell carcinoma than in adenocarcinoma. In cell lines and in patients, WT and I21R HLTF mRNAs were detected, but the latter at lower level. The subgroup of 25 patients presenting a combined low WT HLTF expression and a high I21R HLTF expression had a significantly worse disease-free survival than the other 146 patients in univariate (HR 1.96, CI 1.17–3.30; p = 0.011) and multivariate analyses (HR 1.98, CI 1.15–3.40; p = 0.014). A low WT HLTF expression with a high I21R HLTF expression is associated with a poor DFS." @default.
• W2801061298 created "2018-05-17" @default.
• W2801061298 creator A5004247939 @default.
• W2801061298 creator A5025012859 @default.
• W2801061298 creator A5029475794 @default.
• W2801061298 creator A5031467567 @default.
• W2801061298 creator A5034397098 @default.
• W2801061298 creator A5042101921 @default.
• W2801061298 creator A5049172009 @default.
• W2801061298 creator A5063546619 @default.
• W2801061298 creator A5073362806 @default.
• W2801061298 creator A5075347427 @default.
• W2801061298 date "2018-04-16" @default.
• W2801061298 modified "2023-10-06" @default.
• W2801061298 title "Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC)" @default.
• W2801061298 cites W1987875441 @default.
• W2801061298 cites W1991489744 @default.
• W2801061298 cites W2031752090 @default.
• W2801061298 cites W2041190083 @default.
• W2801061298 cites W2044511377 @default.
• W2801061298 cites W2058328231 @default.
• W2801061298 cites W2085035904 @default.
• W2801061298 cites W2088720324 @default.
• W2801061298 cites W2098824335 @default.
• W2801061298 cites W2100974599 @default.
• W2801061298 cites W2110743612 @default.
• W2801061298 cites W2110966169 @default.
• W2801061298 cites W2113224775 @default.
• W2801061298 cites W2115731013 @default.
• W2801061298 cites W2118151336 @default.
• W2801061298 cites W2121555934 @default.
• W2801061298 cites W2122623363 @default.
• W2801061298 cites W2124302221 @default.
• W2801061298 cites W2131635724 @default.
• W2801061298 cites W2156307964 @default.
• W2801061298 cites W2169385429 @default.
• W2801061298 cites W2169961966 @default.
• W2801061298 cites W2194548253 @default.
• W2801061298 cites W2219978888 @default.
• W2801061298 cites W246102073 @default.
• W2801061298 doi "https://doi.org/10.1186/s12885-018-4215-y" @default.
• W2801061298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5902896" @default.
• W2801061298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29661164" @default.
• W2801061298 hasPublicationYear "2018" @default.
• W2801061298 type Work @default.
• W2801061298 sameAs 2801061298 @default.
• W2801061298 citedByCount "3" @default.
• W2801061298 countsByYear W28010612982019 @default.
• W2801061298 countsByYear W28010612982020 @default.
• W2801061298 countsByYear W28010612982023 @default.
• W2801061298 crossrefType "journal-article" @default.
• W2801061298 hasAuthorship W2801061298A5004247939 @default.
• W2801061298 hasAuthorship W2801061298A5025012859 @default.
• W2801061298 hasAuthorship W2801061298A5029475794 @default.
• W2801061298 hasAuthorship W2801061298A5031467567 @default.
• W2801061298 hasAuthorship W2801061298A5034397098 @default.
• W2801061298 hasAuthorship W2801061298A5042101921 @default.
• W2801061298 hasAuthorship W2801061298A5049172009 @default.
• W2801061298 hasAuthorship W2801061298A5063546619 @default.
• W2801061298 hasAuthorship W2801061298A5073362806 @default.
• W2801061298 hasAuthorship W2801061298A5075347427 @default.
• W2801061298 hasBestOaLocation W28010612981 @default.
• W2801061298 hasConcept C104317684 @default.
• W2801061298 hasConcept C126322002 @default.
• W2801061298 hasConcept C143998085 @default.
• W2801061298 hasConcept C2776256026 @default.
• W2801061298 hasConcept C502942594 @default.
• W2801061298 hasConcept C54355233 @default.
• W2801061298 hasConcept C71924100 @default.
• W2801061298 hasConcept C86339819 @default.
• W2801061298 hasConcept C86803240 @default.
• W2801061298 hasConceptScore W2801061298C104317684 @default.
• W2801061298 hasConceptScore W2801061298C126322002 @default.
• W2801061298 hasConceptScore W2801061298C143998085 @default.
• W2801061298 hasConceptScore W2801061298C2776256026 @default.
• W2801061298 hasConceptScore W2801061298C502942594 @default.
• W2801061298 hasConceptScore W2801061298C54355233 @default.
• W2801061298 hasConceptScore W2801061298C71924100 @default.
• W2801061298 hasConceptScore W2801061298C86339819 @default.
• W2801061298 hasConceptScore W2801061298C86803240 @default.
• W2801061298 hasFunder F4320320118 @default.
• W2801061298 hasFunder F4320320868 @default.
• W2801061298 hasFunder F4320321390 @default.
• W2801061298 hasIssue "1" @default.
• W2801061298 hasLocation W28010612981 @default.
• W2801061298 hasLocation W28010612982 @default.
• W2801061298 hasLocation W28010612983 @default.
• W2801061298 hasLocation W28010612984 @default.
• W2801061298 hasLocation W28010612985 @default.
• W2801061298 hasLocation W28010612986 @default.
• W2801061298 hasLocation W28010612987 @default.
• W2801061298 hasOpenAccess W2801061298 @default.
• W2801061298 hasPrimaryLocation W28010612981 @default.
• W2801061298 hasRelatedWork W1967103478 @default.
• W2801061298 hasRelatedWork W1975595193 @default.
• W2801061298 hasRelatedWork W2032912323 @default.
• W2801061298 hasRelatedWork W2057841153 @default.
• W2801061298 hasRelatedWork W2372561159 @default.
• W2801061298 hasRelatedWork W2375344515 @default.
• W2801061298 hasRelatedWork W2387455091 @default.

• next