Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801071713> ?p ?o ?g. }
- W2801071713 abstract "Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration of RA pathogenesis is still a mystery. Collagen induced arthritis (CIA) in rats is an established model that shares many similarities with RA in humans. In this study we investigated the effect of Bi-Qi on the pathogenesis of CIA in rats. CIA was developed in Sprague-Dawley (S.D) rats (n = 60, female) and used as a model resembling RA in humans. Rats were treated with a high or moderate dose of Bi-Qi, or methotrexate (MTX). Effects of the treatment on local joint and systemic inflammation, synovial hyperplasia, cartilage destruction, and other main features in the pathogenesis of CIA were analyzed. Inflamed and swollen ankles and joints were observed in arthritic rats, while Bi-Qi or MTX treatment alleviated these symptoms. Only the Bi-Qi moderate dose decreased RA-induced serum levels of tumor necrosis factor-alpha (TNF-α). Both Bi-Qi and MTX reduced the interleukin (IL)-18 serum level. Protein levels of cartilage oligomeric matrix protein and osteopontin in serum, synovium, and cartilage were elevated in arthritic rats, while Bi-Qi alleviated these effects. Synovial hyperplasia, inflammatory cell infiltration in synovium and a high degree of cartilage degradation was observed in RA, and Bi-Qi or MTX alleviated this effect. Bi-Qi at the moderate dose was the most effective in mitigating CIA-related clinical complications. Our findings showed that Bi-Qi alleviates CIA-induced inflammation, synovial hyperplasia, cartilage destruction, and the other main features in the pathogenesis of CIA. This provides fundamental evidence for the anti-arthritic properties of Bi-Qi and corroborates the use of Bi-Qi TCM formula for the treatment of RA." @default.
- W2801071713 created "2018-05-17" @default.
- W2801071713 creator A5005036075 @default.
- W2801071713 creator A5007348590 @default.
- W2801071713 creator A5008449879 @default.
- W2801071713 creator A5009562280 @default.
- W2801071713 creator A5021293751 @default.
- W2801071713 creator A5038440124 @default.
- W2801071713 creator A5073531557 @default.
- W2801071713 creator A5082001172 @default.
- W2801071713 creator A5082757383 @default.
- W2801071713 date "2018-03-14" @default.
- W2801071713 modified "2023-10-06" @default.
- W2801071713 title "Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats" @default.
- W2801071713 cites W1523661940 @default.
- W2801071713 cites W1909853035 @default.
- W2801071713 cites W1976912963 @default.
- W2801071713 cites W1980007287 @default.
- W2801071713 cites W1984463932 @default.
- W2801071713 cites W1997775451 @default.
- W2801071713 cites W2001213139 @default.
- W2801071713 cites W2016969993 @default.
- W2801071713 cites W2026726039 @default.
- W2801071713 cites W2028014480 @default.
- W2801071713 cites W2029239231 @default.
- W2801071713 cites W2029524219 @default.
- W2801071713 cites W2042003633 @default.
- W2801071713 cites W2049358928 @default.
- W2801071713 cites W2057114015 @default.
- W2801071713 cites W2074438676 @default.
- W2801071713 cites W2074942008 @default.
- W2801071713 cites W2101420478 @default.
- W2801071713 cites W2110826367 @default.
- W2801071713 cites W2112066013 @default.
- W2801071713 cites W2119995172 @default.
- W2801071713 cites W2128952811 @default.
- W2801071713 cites W2131594425 @default.
- W2801071713 cites W2135417134 @default.
- W2801071713 cites W2140966294 @default.
- W2801071713 cites W2141481869 @default.
- W2801071713 cites W2141705824 @default.
- W2801071713 cites W2146607274 @default.
- W2801071713 cites W2150452958 @default.
- W2801071713 cites W2155702314 @default.
- W2801071713 cites W2159560982 @default.
- W2801071713 cites W2172038777 @default.
- W2801071713 cites W2297049123 @default.
- W2801071713 cites W2311442028 @default.
- W2801071713 cites W2336588424 @default.
- W2801071713 cites W2381147818 @default.
- W2801071713 cites W2398890150 @default.
- W2801071713 cites W2465892722 @default.
- W2801071713 cites W2616933475 @default.
- W2801071713 cites W2621061076 @default.
- W2801071713 cites W2738879896 @default.
- W2801071713 cites W4241917186 @default.
- W2801071713 doi "https://doi.org/10.1186/s13075-018-1547-6" @default.
- W2801071713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5853033" @default.
- W2801071713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29540195" @default.
- W2801071713 hasPublicationYear "2018" @default.
- W2801071713 type Work @default.
- W2801071713 sameAs 2801071713 @default.
- W2801071713 citedByCount "28" @default.
- W2801071713 countsByYear W28010717132018 @default.
- W2801071713 countsByYear W28010717132019 @default.
- W2801071713 countsByYear W28010717132020 @default.
- W2801071713 countsByYear W28010717132021 @default.
- W2801071713 countsByYear W28010717132022 @default.
- W2801071713 countsByYear W28010717132023 @default.
- W2801071713 crossrefType "journal-article" @default.
- W2801071713 hasAuthorship W2801071713A5005036075 @default.
- W2801071713 hasAuthorship W2801071713A5007348590 @default.
- W2801071713 hasAuthorship W2801071713A5008449879 @default.
- W2801071713 hasAuthorship W2801071713A5009562280 @default.
- W2801071713 hasAuthorship W2801071713A5021293751 @default.
- W2801071713 hasAuthorship W2801071713A5038440124 @default.
- W2801071713 hasAuthorship W2801071713A5073531557 @default.
- W2801071713 hasAuthorship W2801071713A5082001172 @default.
- W2801071713 hasAuthorship W2801071713A5082757383 @default.
- W2801071713 hasBestOaLocation W28010717131 @default.
- W2801071713 hasConcept C105702510 @default.
- W2801071713 hasConcept C126322002 @default.
- W2801071713 hasConcept C142724271 @default.
- W2801071713 hasConcept C17991360 @default.
- W2801071713 hasConcept C198451711 @default.
- W2801071713 hasConcept C203014093 @default.
- W2801071713 hasConcept C204787440 @default.
- W2801071713 hasConcept C2776164576 @default.
- W2801071713 hasConcept C2776914184 @default.
- W2801071713 hasConcept C2777077863 @default.
- W2801071713 hasConcept C2777562237 @default.
- W2801071713 hasConcept C2777575956 @default.
- W2801071713 hasConcept C2780550940 @default.
- W2801071713 hasConcept C2780942790 @default.
- W2801071713 hasConcept C2781059491 @default.
- W2801071713 hasConcept C71924100 @default.
- W2801071713 hasConceptScore W2801071713C105702510 @default.
- W2801071713 hasConceptScore W2801071713C126322002 @default.
- W2801071713 hasConceptScore W2801071713C142724271 @default.
- W2801071713 hasConceptScore W2801071713C17991360 @default.