Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801077228> ?p ?o ?g. }
- W2801077228 endingPage "2419" @default.
- W2801077228 startingPage "2409" @default.
- W2801077228 abstract "Mechanically induced signaling pathways are important drivers of tumor progression. However, if and how mechanical signals affect metastasis or therapy response remains poorly understood. We previously found that the channel-kinase TRPM7, a regulator of cellular tension implicated in mechano-sensory processes, is required for breast cancer metastasis in vitro and in vivo. Here, we show that TRPM7 contributes to maintaining a mesenchymal phenotype in breast cancer cells by tensional regulation of the EMT transcription factor SOX4. The functional consequences of SOX4 knockdown closely mirror those produced by TRPM7 knockdown. By traction force measurements, we demonstrate that TRPM7 reduces cytoskeletal tension through inhibition of myosin II activity. Moreover, we show that SOX4 expression and downstream mesenchymal markers are inversely regulated by cytoskeletal tension and matrix rigidity. Overall, our results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4." @default.
- W2801077228 created "2018-05-17" @default.
- W2801077228 creator A5019907039 @default.
- W2801077228 creator A5027143058 @default.
- W2801077228 creator A5027994094 @default.
- W2801077228 creator A5031426703 @default.
- W2801077228 creator A5038325579 @default.
- W2801077228 creator A5047683911 @default.
- W2801077228 creator A5057304839 @default.
- W2801077228 creator A5064687284 @default.
- W2801077228 creator A5085834116 @default.
- W2801077228 date "2018-07-01" @default.
- W2801077228 modified "2023-10-09" @default.
- W2801077228 title "TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4" @default.
- W2801077228 cites W1631541550 @default.
- W2801077228 cites W1837965070 @default.
- W2801077228 cites W1963501822 @default.
- W2801077228 cites W1964081206 @default.
- W2801077228 cites W1964847767 @default.
- W2801077228 cites W1982872797 @default.
- W2801077228 cites W1985042934 @default.
- W2801077228 cites W1985770572 @default.
- W2801077228 cites W1986345331 @default.
- W2801077228 cites W1987557442 @default.
- W2801077228 cites W1989095124 @default.
- W2801077228 cites W1989168851 @default.
- W2801077228 cites W1997929441 @default.
- W2801077228 cites W1999920543 @default.
- W2801077228 cites W2000099772 @default.
- W2801077228 cites W2000465700 @default.
- W2801077228 cites W2007149178 @default.
- W2801077228 cites W2008324315 @default.
- W2801077228 cites W2015207227 @default.
- W2801077228 cites W2016081742 @default.
- W2801077228 cites W2018173558 @default.
- W2801077228 cites W2022645001 @default.
- W2801077228 cites W2022746045 @default.
- W2801077228 cites W2024315189 @default.
- W2801077228 cites W2030642623 @default.
- W2801077228 cites W2038753908 @default.
- W2801077228 cites W2040430549 @default.
- W2801077228 cites W2043870864 @default.
- W2801077228 cites W2043999650 @default.
- W2801077228 cites W2044766422 @default.
- W2801077228 cites W2046372462 @default.
- W2801077228 cites W2051385775 @default.
- W2801077228 cites W2058096164 @default.
- W2801077228 cites W2061546218 @default.
- W2801077228 cites W2066905281 @default.
- W2801077228 cites W2075121911 @default.
- W2801077228 cites W2081121476 @default.
- W2801077228 cites W2084272633 @default.
- W2801077228 cites W2086244192 @default.
- W2801077228 cites W2087668761 @default.
- W2801077228 cites W2087850490 @default.
- W2801077228 cites W2088106349 @default.
- W2801077228 cites W2088392532 @default.
- W2801077228 cites W2092412094 @default.
- W2801077228 cites W2092480048 @default.
- W2801077228 cites W2093021491 @default.
- W2801077228 cites W2093057360 @default.
- W2801077228 cites W2093723806 @default.
- W2801077228 cites W2096331437 @default.
- W2801077228 cites W2097444304 @default.
- W2801077228 cites W2099052265 @default.
- W2801077228 cites W2100122781 @default.
- W2801077228 cites W2102661335 @default.
- W2801077228 cites W2105072296 @default.
- W2801077228 cites W2110834542 @default.
- W2801077228 cites W2113304856 @default.
- W2801077228 cites W2115124692 @default.
- W2801077228 cites W2116413963 @default.
- W2801077228 cites W2121933066 @default.
- W2801077228 cites W2132264780 @default.
- W2801077228 cites W2134208433 @default.
- W2801077228 cites W2137135901 @default.
- W2801077228 cites W2140606720 @default.
- W2801077228 cites W2141075109 @default.
- W2801077228 cites W2141738357 @default.
- W2801077228 cites W2143001044 @default.
- W2801077228 cites W2144023435 @default.
- W2801077228 cites W2145329837 @default.
- W2801077228 cites W2146337514 @default.
- W2801077228 cites W2147194859 @default.
- W2801077228 cites W2167246201 @default.
- W2801077228 cites W2220804656 @default.
- W2801077228 cites W2307471243 @default.
- W2801077228 cites W2414831439 @default.
- W2801077228 cites W2461967856 @default.
- W2801077228 cites W2517007838 @default.
- W2801077228 cites W2733398634 @default.
- W2801077228 cites W4211069901 @default.
- W2801077228 doi "https://doi.org/10.1016/j.bbadis.2018.04.017" @default.
- W2801077228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29684587" @default.
- W2801077228 hasPublicationYear "2018" @default.
- W2801077228 type Work @default.
- W2801077228 sameAs 2801077228 @default.
- W2801077228 citedByCount "28" @default.