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- W2801080092 abstract "Permanent hearing loss is often a result of damage to cochlear hair cells, which mammals are unable to regenerate. Non-mammalian vertebrates such as birds replace damaged hair cells and restore hearing function, but mechanisms controlling regeneration are not understood. The secreted protein bone morphogenetic protein 4 (BMP4) regulates inner ear morphogenesis and hair cell development. To investigate mechanisms controlling hair cell regeneration in birds, we examined expression and function of BMP4 in the auditory epithelia (basilar papillae) of chickens of either sex after hair cell destruction by ototoxic antibiotics. In mature basilar papillae, BMP4 mRNA is highly expressed in hair cells, but not in hair cell progenitors (supporting cells). Supporting cells transcribe genes encoding receptors for BMP4 (BMPR1A, BMPR1B, and BMPR2) and effectors of BMP4 signaling (ID transcription factors). Following hair cell destruction, BMP4 transcripts are lost from the sensory epithelium. Using organotypic cultures, we demonstrate that treatments with BMP4 during hair cell destruction prevent supporting cells from upregulating expression of the pro-hair cell transcription factor ATOH1, entering the cell cycle, and fully transdifferentiating into hair cells, but they do not induce cell death. By contrast, noggin, a BMP4 inhibitor, increases numbers of regenerated hair cells. These findings demonstrate that BMP4 antagonizes hair cell regeneration in the chicken basilar papilla, at least in part by preventing accumulation of ATOH1 in hair cell precursors." @default.
- W2801080092 created "2018-05-17" @default.
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- W2801080092 creator A5090694573 @default.
- W2801080092 date "2018-07-01" @default.
- W2801080092 modified "2023-10-16" @default.
- W2801080092 title "Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium" @default.
- W2801080092 cites W1580667945 @default.
- W2801080092 cites W1846455627 @default.
- W2801080092 cites W1860795244 @default.
- W2801080092 cites W1890207703 @default.
- W2801080092 cites W1905082404 @default.
- W2801080092 cites W1910819802 @default.
- W2801080092 cites W1953633452 @default.
- W2801080092 cites W1968802207 @default.
- W2801080092 cites W1970288230 @default.
- W2801080092 cites W1975527788 @default.
- W2801080092 cites W1976318182 @default.
- W2801080092 cites W1979509265 @default.
- W2801080092 cites W1979881566 @default.
- W2801080092 cites W1981780292 @default.
- W2801080092 cites W1987447759 @default.
- W2801080092 cites W1992949513 @default.
- W2801080092 cites W2001423147 @default.
- W2801080092 cites W2005143680 @default.
- W2801080092 cites W2008854216 @default.
- W2801080092 cites W2013935392 @default.
- W2801080092 cites W2014267924 @default.
- W2801080092 cites W2015029839 @default.
- W2801080092 cites W2016667404 @default.
- W2801080092 cites W2017453705 @default.
- W2801080092 cites W2020603167 @default.
- W2801080092 cites W2022586478 @default.
- W2801080092 cites W2025817090 @default.
- W2801080092 cites W2026120980 @default.
- W2801080092 cites W2028916500 @default.
- W2801080092 cites W2032931864 @default.
- W2801080092 cites W2033763031 @default.
- W2801080092 cites W2036333303 @default.
- W2801080092 cites W2042111556 @default.
- W2801080092 cites W2044947020 @default.
- W2801080092 cites W2045204862 @default.
- W2801080092 cites W2046051277 @default.
- W2801080092 cites W2046972763 @default.
- W2801080092 cites W2049365404 @default.
- W2801080092 cites W2049903984 @default.
- W2801080092 cites W2049931261 @default.
- W2801080092 cites W2050071487 @default.
- W2801080092 cites W2053430145 @default.
- W2801080092 cites W2059763574 @default.
- W2801080092 cites W2067150453 @default.
- W2801080092 cites W2067986718 @default.
- W2801080092 cites W2068342119 @default.
- W2801080092 cites W2075621877 @default.
- W2801080092 cites W2084489417 @default.
- W2801080092 cites W2085157715 @default.
- W2801080092 cites W2088483102 @default.
- W2801080092 cites W2091231865 @default.
- W2801080092 cites W2104593931 @default.
- W2801080092 cites W2112903125 @default.
- W2801080092 cites W2112938192 @default.
- W2801080092 cites W2129384667 @default.
- W2801080092 cites W2129679172 @default.
- W2801080092 cites W2137826349 @default.
- W2801080092 cites W2139402596 @default.
- W2801080092 cites W2141569557 @default.
- W2801080092 cites W2147235457 @default.
- W2801080092 cites W2147507695 @default.
- W2801080092 cites W2148965620 @default.
- W2801080092 cites W2154409385 @default.
- W2801080092 cites W2156182988 @default.
- W2801080092 cites W2156993914 @default.
- W2801080092 cites W2158129482 @default.
- W2801080092 cites W2159511823 @default.
- W2801080092 cites W2164961459 @default.
- W2801080092 cites W2164984178 @default.
- W2801080092 cites W2171091598 @default.
- W2801080092 cites W2186244224 @default.
- W2801080092 cites W2395015655 @default.
- W2801080092 cites W2414555491 @default.
- W2801080092 cites W2518788752 @default.
- W2801080092 cites W2783163921 @default.
- W2801080092 cites W4238317003 @default.
- W2801080092 cites W4323284461 @default.
- W2801080092 doi "https://doi.org/10.1016/j.heares.2018.04.008" @default.
- W2801080092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5984193" @default.
- W2801080092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29754876" @default.
- W2801080092 hasPublicationYear "2018" @default.
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