FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801082945> ?p ?o ?g. }

• W2801082945 abstract "Objective: Inadequate protein intake can impair protein balance thus leading to skeletal muscle atrophy, impaired body growth, and functional decline. Foods provide both non-essential (NEAAs) and essential amino acids (EAAs) that may convey different metabolic stimuli to specific organs and tissues. In this study, we sought to evaluate the impact of six diets, with various EAA/NEAA blends, on body composition and the risk of developing tissue wasting in late middle-aged male mice. Methods: Six groups of late middle-aged male mice were fed for 35 days with iso-nutrients, iso-caloric and iso-nitrogenous special diets containing different EAA/NEAA ratios ranging from 100%/0% to 0%/100%. One group fed with standard laboratory rodent diet (StD) served as control. Preliminarily, we verified the palatability of the diets by recording the mice preference, and by making accessible all diets simultaneously, in comparison to StD. Body weight, food and water consumption were measured every three days. Blood and urine samples, as well as heart, kidneys, liver, spleen, triceps surae, retroperitoneal WAT, and BAT were harvested and weighed. Results: Mice consuming NEAA-based diets, although showing increased food and calorie intake, suffered the most severe weight loss. Interestingly, the diet containing a EAA/NEAA-imbalance, with moderate NEAAs prevalence, was able to induce catabolic stimuli, generalized body wasting and systemic metabolic alterations comparable to those observed with diet containing NEAA alone. In addition, complete depletion of retroperitoneal white adipose tissue and a severe loss (>75%) of brown adipose tissue were observed together with muscle wasting. Conversely, EAA-containing diets induced significant decreases in body weight by reducing primarily fat reserves, but at the same time they improved the clinical parameters. On these basis we can deduce that tissue wasting was caused by altered AA quality, independent of reduced nitrogen or caloric intake. Conclusion: Our results indicate that diets containing an optimized balance of AA composition is necessary for preserving overall body energy status. These findings are particularly relevant in the context of aging and may be exploited for contrasting its negative correlates, including body wasting." @default.
• W2801082945 created "2018-05-17" @default.
• W2801082945 creator A5001960093 @default.
• W2801082945 creator A5006290113 @default.
• W2801082945 creator A5011273738 @default.
• W2801082945 creator A5022126213 @default.
• W2801082945 creator A5028025117 @default.
• W2801082945 creator A5049412879 @default.
• W2801082945 creator A5058040400 @default.
• W2801082945 creator A5061789219 @default.
• W2801082945 date "2018-05-17" @default.
• W2801082945 modified "2023-10-01" @default.
• W2801082945 title "Body Weight Loss and Tissue Wasting in Late Middle-Aged Mice on Slightly Imbalanced Essential/Non-essential Amino Acids Diet" @default.
• W2801082945 cites W1559597486 @default.
• W2801082945 cites W1873596396 @default.
• W2801082945 cites W1936852270 @default.
• W2801082945 cites W1966522513 @default.
• W2801082945 cites W1981334514 @default.
• W2801082945 cites W1986013095 @default.
• W2801082945 cites W1996518681 @default.
• W2801082945 cites W1998371821 @default.
• W2801082945 cites W1998559329 @default.
• W2801082945 cites W2003064100 @default.
• W2801082945 cites W2009350046 @default.
• W2801082945 cites W201565554 @default.
• W2801082945 cites W2017726641 @default.
• W2801082945 cites W2053706331 @default.
• W2801082945 cites W2055648396 @default.
• W2801082945 cites W2055691049 @default.
• W2801082945 cites W2064021628 @default.
• W2801082945 cites W2075287122 @default.
• W2801082945 cites W2087642938 @default.
• W2801082945 cites W2104847513 @default.
• W2801082945 cites W2105526873 @default.
• W2801082945 cites W2147379012 @default.
• W2801082945 cites W2156523912 @default.
• W2801082945 cites W2165171386 @default.
• W2801082945 cites W2167431561 @default.
• W2801082945 cites W2168761441 @default.
• W2801082945 cites W2170985498 @default.
• W2801082945 cites W2186505043 @default.
• W2801082945 cites W2217809975 @default.
• W2801082945 cites W2234006279 @default.
• W2801082945 cites W2268315353 @default.
• W2801082945 cites W2300000033 @default.
• W2801082945 cites W2516805878 @default.
• W2801082945 cites W2604145211 @default.
• W2801082945 cites W2615378956 @default.
• W2801082945 cites W2732689531 @default.
• W2801082945 cites W2785085010 @default.
• W2801082945 cites W69998986 @default.
• W2801082945 doi "https://doi.org/10.3389/fmed.2018.00136" @default.
• W2801082945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5966530" @default.
• W2801082945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29868589" @default.
• W2801082945 hasPublicationYear "2018" @default.
• W2801082945 type Work @default.
• W2801082945 sameAs 2801082945 @default.
• W2801082945 citedByCount "12" @default.
• W2801082945 countsByYear W28010829452018 @default.
• W2801082945 countsByYear W28010829452019 @default.
• W2801082945 countsByYear W28010829452020 @default.
• W2801082945 countsByYear W28010829452021 @default.
• W2801082945 countsByYear W28010829452022 @default.
• W2801082945 crossrefType "journal-article" @default.
• W2801082945 hasAuthorship W2801082945A5001960093 @default.
• W2801082945 hasAuthorship W2801082945A5006290113 @default.
• W2801082945 hasAuthorship W2801082945A5011273738 @default.
• W2801082945 hasAuthorship W2801082945A5022126213 @default.
• W2801082945 hasAuthorship W2801082945A5028025117 @default.
• W2801082945 hasAuthorship W2801082945A5049412879 @default.
• W2801082945 hasAuthorship W2801082945A5058040400 @default.
• W2801082945 hasAuthorship W2801082945A5061789219 @default.
• W2801082945 hasBestOaLocation W28010829451 @default.
• W2801082945 hasConcept C1008401 @default.
• W2801082945 hasConcept C126322002 @default.
• W2801082945 hasConcept C134018914 @default.
• W2801082945 hasConcept C142724271 @default.
• W2801082945 hasConcept C151955695 @default.
• W2801082945 hasConcept C171089720 @default.
• W2801082945 hasConcept C172873279 @default.
• W2801082945 hasConcept C2776214593 @default.
• W2801082945 hasConcept C2779764123 @default.
• W2801082945 hasConcept C2779959927 @default.
• W2801082945 hasConcept C2780642333 @default.
• W2801082945 hasConcept C2781172350 @default.
• W2801082945 hasConcept C40438245 @default.
• W2801082945 hasConcept C42407357 @default.
• W2801082945 hasConcept C511355011 @default.
• W2801082945 hasConcept C544821477 @default.
• W2801082945 hasConcept C71924100 @default.
• W2801082945 hasConcept C86803240 @default.
• W2801082945 hasConceptScore W2801082945C1008401 @default.
• W2801082945 hasConceptScore W2801082945C126322002 @default.
• W2801082945 hasConceptScore W2801082945C134018914 @default.
• W2801082945 hasConceptScore W2801082945C142724271 @default.
• W2801082945 hasConceptScore W2801082945C151955695 @default.
• W2801082945 hasConceptScore W2801082945C171089720 @default.
• W2801082945 hasConceptScore W2801082945C172873279 @default.
• W2801082945 hasConceptScore W2801082945C2776214593 @default.
• W2801082945 hasConceptScore W2801082945C2779764123 @default.

• next