Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801101056> ?p ?o ?g. }
- W2801101056 endingPage "248" @default.
- W2801101056 startingPage "248" @default.
- W2801101056 abstract "Brain tumors are regarded as the most prevalent solid neoplasms in children and the principal reason of death in this population. Even though surgical resection, radiotherapy and chemotherapy have improved outcome, a significant number of patients die in 6-12 months after diagnosis while those who survive, frequently experience side effects and relapses. Several studies suggest that many types of cancer including pediatric brain tumors are characterized by alterations in epigenetic profiles with deregulated chromatin remodeling and posttranslational covalent histone modifications playing a prominent role. Moreover, interplay of genetic and epigenetic changes has been associated to tumor growth and invasion as well as to modulation of patient's response to current treatment. Therefore, detection of tumor-specific histone changes and elucidation of the underlying gene defects will allow successful tailoring of personalized treatment. The goal of this review is to provide an update of genetic and epigenetic alterations that characterize pediatric brain tumors focusing on histone modifications, aiming at directing future molecular and epigenetic therapeutic targeting." @default.
- W2801101056 created "2018-05-17" @default.
- W2801101056 creator A5017473942 @default.
- W2801101056 creator A5056605879 @default.
- W2801101056 creator A5073241679 @default.
- W2801101056 creator A5077783091 @default.
- W2801101056 creator A5082726768 @default.
- W2801101056 date "2018-06-01" @default.
- W2801101056 modified "2023-10-16" @default.
- W2801101056 title "Chromatin remodeling defects in pediatric brain tumors" @default.
- W2801101056 cites W1494085100 @default.
- W2801101056 cites W1535135245 @default.
- W2801101056 cites W1900971264 @default.
- W2801101056 cites W1922450129 @default.
- W2801101056 cites W1965766554 @default.
- W2801101056 cites W1968931043 @default.
- W2801101056 cites W1971313898 @default.
- W2801101056 cites W1974625077 @default.
- W2801101056 cites W1976979641 @default.
- W2801101056 cites W1977836335 @default.
- W2801101056 cites W1978480482 @default.
- W2801101056 cites W1980767402 @default.
- W2801101056 cites W1983085353 @default.
- W2801101056 cites W1984139221 @default.
- W2801101056 cites W1984629114 @default.
- W2801101056 cites W1988126723 @default.
- W2801101056 cites W1995105508 @default.
- W2801101056 cites W2003070261 @default.
- W2801101056 cites W2004456850 @default.
- W2801101056 cites W2006540058 @default.
- W2801101056 cites W2009308370 @default.
- W2801101056 cites W2011181841 @default.
- W2801101056 cites W2017308570 @default.
- W2801101056 cites W2022930470 @default.
- W2801101056 cites W2027962334 @default.
- W2801101056 cites W2028643362 @default.
- W2801101056 cites W2033130827 @default.
- W2801101056 cites W2038120157 @default.
- W2801101056 cites W2040859868 @default.
- W2801101056 cites W2043033879 @default.
- W2801101056 cites W2044836474 @default.
- W2801101056 cites W2047141809 @default.
- W2801101056 cites W2049487259 @default.
- W2801101056 cites W2051921450 @default.
- W2801101056 cites W2053349906 @default.
- W2801101056 cites W2055027888 @default.
- W2801101056 cites W2057460011 @default.
- W2801101056 cites W2059060292 @default.
- W2801101056 cites W2062062519 @default.
- W2801101056 cites W2072441383 @default.
- W2801101056 cites W2074145013 @default.
- W2801101056 cites W2075052598 @default.
- W2801101056 cites W2075608121 @default.
- W2801101056 cites W2076910437 @default.
- W2801101056 cites W2089193884 @default.
- W2801101056 cites W2091925303 @default.
- W2801101056 cites W2095071758 @default.
- W2801101056 cites W2097626332 @default.
- W2801101056 cites W2098052125 @default.
- W2801101056 cites W2100365251 @default.
- W2801101056 cites W2101546733 @default.
- W2801101056 cites W2105224792 @default.
- W2801101056 cites W2108522140 @default.
- W2801101056 cites W2113432767 @default.
- W2801101056 cites W2116532772 @default.
- W2801101056 cites W2117559539 @default.
- W2801101056 cites W2118124054 @default.
- W2801101056 cites W2118837528 @default.
- W2801101056 cites W2119220037 @default.
- W2801101056 cites W2123046490 @default.
- W2801101056 cites W2124839835 @default.
- W2801101056 cites W2126085546 @default.
- W2801101056 cites W2127643721 @default.
- W2801101056 cites W2127674449 @default.
- W2801101056 cites W2129697031 @default.
- W2801101056 cites W2136079563 @default.
- W2801101056 cites W2139771301 @default.
- W2801101056 cites W2140266186 @default.
- W2801101056 cites W2145489645 @default.
- W2801101056 cites W2151311897 @default.
- W2801101056 cites W2154930876 @default.
- W2801101056 cites W2158233796 @default.
- W2801101056 cites W2161535481 @default.
- W2801101056 cites W2164111169 @default.
- W2801101056 cites W2164984854 @default.
- W2801101056 cites W2170598035 @default.
- W2801101056 cites W2171425841 @default.
- W2801101056 cites W2242029997 @default.
- W2801101056 cites W2289297469 @default.
- W2801101056 cites W2337106083 @default.
- W2801101056 cites W2403601567 @default.
- W2801101056 cites W2463925963 @default.
- W2801101056 cites W2549992612 @default.
- W2801101056 cites W2570448286 @default.
- W2801101056 cites W2593014410 @default.
- W2801101056 cites W2593125811 @default.
- W2801101056 cites W2595613950 @default.
- W2801101056 cites W2603517011 @default.