FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801109672> ?p ?o ?g. }

• W2801109672 endingPage "23461" @default.
• W2801109672 startingPage "23451" @default.
• W2801109672 abstract "Aromatase inhibitor (AI) resistance is a major obstacle in the treatment of estrogen receptor-positive breast cancer. Everolimus (EVE) ameliorates AI-resistant breast cancer and is therefore used in cancer treatment. However, some patients show resistance to EVE. Here, we used 30 clones of long-term estrogen-deprived (LTED) MCF-7 cells as a model of AI-resistant breast cancer. We examined changes in protein phosphatase type 2A (PP2A) and cancerous inhibitor of PP2A (CIP2A), a negative regulator of PP2A, in LTED cells treated with EVE. In LTED cells with high sensitivity to EVE, CIP2A expression decreased at low EVE concentrations; however, in LTED cells poorly sensitive to EVE, CIP2A and PP2A did not change upon exposure to EVE. Therefore, we hypothesized that there is a relation between expression of CIP2A and sensitivity to EVE. Knockdown of CIP2A increased the sensitivity to EVE in three clones poorly sensitive to EVE. Additionally, we found that treatment with FSK, which activates PP2A, increased the sensitivity of the cells to EVE. Our data point to CIP2A and PP2A as novel therapeutic targets for AI-resistant breast cancer." @default.
• W2801109672 created "2018-05-17" @default.
• W2801109672 creator A5015103500 @default.
• W2801109672 creator A5019590813 @default.
• W2801109672 creator A5032553313 @default.
• W2801109672 creator A5049143412 @default.
• W2801109672 creator A5070386484 @default.
• W2801109672 creator A5080789663 @default.
• W2801109672 creator A5086111708 @default.
• W2801109672 date "2018-05-04" @default.
• W2801109672 modified "2023-09-28" @default.
• W2801109672 title "Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells" @default.
• W2801109672 cites W1548598561 @default.
• W2801109672 cites W1571338740 @default.
• W2801109672 cites W1585521882 @default.
• W2801109672 cites W1740740591 @default.
• W2801109672 cites W1944448503 @default.
• W2801109672 cites W1964086531 @default.
• W2801109672 cites W1972236331 @default.
• W2801109672 cites W1982866065 @default.
• W2801109672 cites W1997099126 @default.
• W2801109672 cites W1997961187 @default.
• W2801109672 cites W2006091725 @default.
• W2801109672 cites W2009504099 @default.
• W2801109672 cites W2017958579 @default.
• W2801109672 cites W2033344337 @default.
• W2801109672 cites W2037657103 @default.
• W2801109672 cites W2055386238 @default.
• W2801109672 cites W2061377707 @default.
• W2801109672 cites W2061673659 @default.
• W2801109672 cites W2067890488 @default.
• W2801109672 cites W2070544692 @default.
• W2801109672 cites W2071183768 @default.
• W2801109672 cites W2077968895 @default.
• W2801109672 cites W2083459920 @default.
• W2801109672 cites W2089738145 @default.
• W2801109672 cites W2094079572 @default.
• W2801109672 cites W2106359723 @default.
• W2801109672 cites W2108326951 @default.
• W2801109672 cites W2112444654 @default.
• W2801109672 cites W2112780046 @default.
• W2801109672 cites W2127758887 @default.
• W2801109672 cites W2129843621 @default.
• W2801109672 cites W2132428290 @default.
• W2801109672 cites W2138748691 @default.
• W2801109672 cites W2146778486 @default.
• W2801109672 cites W2149615486 @default.
• W2801109672 cites W2150366392 @default.
• W2801109672 cites W2151082560 @default.
• W2801109672 cites W2156790143 @default.
• W2801109672 cites W2167188058 @default.
• W2801109672 cites W2169988894 @default.
• W2801109672 cites W2226721679 @default.
• W2801109672 cites W2469070792 @default.
• W2801109672 cites W2471098782 @default.
• W2801109672 cites W2489370798 @default.
• W2801109672 cites W2586089906 @default.
• W2801109672 cites W2589020409 @default.
• W2801109672 cites W2591984005 @default.
• W2801109672 cites W2765960241 @default.
• W2801109672 doi "https://doi.org/10.18632/oncotarget.25217" @default.
• W2801109672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5955115" @default.
• W2801109672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29805747" @default.
• W2801109672 hasPublicationYear "2018" @default.
• W2801109672 type Work @default.
• W2801109672 sameAs 2801109672 @default.
• W2801109672 citedByCount "7" @default.
• W2801109672 countsByYear W28011096722019 @default.
• W2801109672 countsByYear W28011096722020 @default.
• W2801109672 countsByYear W28011096722021 @default.
• W2801109672 countsByYear W28011096722022 @default.
• W2801109672 countsByYear W28011096722023 @default.
• W2801109672 crossrefType "journal-article" @default.
• W2801109672 hasAuthorship W2801109672A5015103500 @default.
• W2801109672 hasAuthorship W2801109672A5019590813 @default.
• W2801109672 hasAuthorship W2801109672A5032553313 @default.
• W2801109672 hasAuthorship W2801109672A5049143412 @default.
• W2801109672 hasAuthorship W2801109672A5070386484 @default.
• W2801109672 hasAuthorship W2801109672A5080789663 @default.
• W2801109672 hasAuthorship W2801109672A5086111708 @default.
• W2801109672 hasBestOaLocation W28011096721 @default.
• W2801109672 hasConcept C11960822 @default.
• W2801109672 hasConcept C121608353 @default.
• W2801109672 hasConcept C126322002 @default.
• W2801109672 hasConcept C173396325 @default.
• W2801109672 hasConcept C178666793 @default.
• W2801109672 hasConcept C2776166826 @default.
• W2801109672 hasConcept C2777164284 @default.
• W2801109672 hasConcept C2778504769 @default.
• W2801109672 hasConcept C2779699572 @default.
• W2801109672 hasConcept C389152 @default.
• W2801109672 hasConcept C502942594 @default.
• W2801109672 hasConcept C530470458 @default.
• W2801109672 hasConcept C54355233 @default.
• W2801109672 hasConcept C71924100 @default.
• W2801109672 hasConcept C81885089 @default.
• W2801109672 hasConcept C84606932 @default.
• W2801109672 hasConcept C86803240 @default.

• next