Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801111149> ?p ?o ?g. }
- W2801111149 endingPage "237" @default.
- W2801111149 startingPage "237" @default.
- W2801111149 abstract "The gastrointestinal tract houses millions of microbes, and thus has evolved several host defense mechanisms to keep them at bay, and prevent their entry into the host. One such mucosal surface defense is the secretion of secretory immunoglobulins (SIg). Secretion of SIg depends on the polymeric immunoglobulin receptor (pIgR), which transports polymeric Ig (IgA or IgM) from the basolateral surface of the epithelium to the apical side. Upon reaching the luminal side, a portion of pIgR, called secretory component (SC) is cleaved off to release Ig, forming SIg. Through antigen-specific and non-specific binding, SIg can modulate microbial communities and pathogenic microbes via several mechanisms: agglutination and exclusion from the epithelial surface, neutralization, or via host immunity and complement activation. Given the crucial role of SIg as a microbial scavenger, some pathogens also evolved ways to modulate and utilize pIgR and SIg to facilitate infection. This review will cover the regulation of the pIgR/SIg cycle, mechanisms of SIg-mediated mucosal protection as well as pathogen utilization of SIg." @default.
- W2801111149 created "2018-05-17" @default.
- W2801111149 creator A5032714357 @default.
- W2801111149 creator A5073169842 @default.
- W2801111149 date "2018-05-03" @default.
- W2801111149 modified "2023-10-16" @default.
- W2801111149 title "The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity" @default.
- W2801111149 cites W1117501509 @default.
- W2801111149 cites W1534080439 @default.
- W2801111149 cites W1549424956 @default.
- W2801111149 cites W1584434179 @default.
- W2801111149 cites W1597991404 @default.
- W2801111149 cites W1601905530 @default.
- W2801111149 cites W1603639652 @default.
- W2801111149 cites W1666442506 @default.
- W2801111149 cites W1841458780 @default.
- W2801111149 cites W1897556059 @default.
- W2801111149 cites W1897748761 @default.
- W2801111149 cites W1919011936 @default.
- W2801111149 cites W1920779337 @default.
- W2801111149 cites W1935780090 @default.
- W2801111149 cites W1944606831 @default.
- W2801111149 cites W1964469480 @default.
- W2801111149 cites W1967971775 @default.
- W2801111149 cites W1968732216 @default.
- W2801111149 cites W1972140850 @default.
- W2801111149 cites W1977275592 @default.
- W2801111149 cites W1978199389 @default.
- W2801111149 cites W1979819026 @default.
- W2801111149 cites W1983514420 @default.
- W2801111149 cites W1987907874 @default.
- W2801111149 cites W1992316276 @default.
- W2801111149 cites W1998761054 @default.
- W2801111149 cites W2001401453 @default.
- W2801111149 cites W2005741947 @default.
- W2801111149 cites W2008414196 @default.
- W2801111149 cites W2010858882 @default.
- W2801111149 cites W2012803668 @default.
- W2801111149 cites W2013635745 @default.
- W2801111149 cites W2014805409 @default.
- W2801111149 cites W2015015427 @default.
- W2801111149 cites W2016767717 @default.
- W2801111149 cites W2020932661 @default.
- W2801111149 cites W2023135766 @default.
- W2801111149 cites W2025574003 @default.
- W2801111149 cites W2027156117 @default.
- W2801111149 cites W2033740187 @default.
- W2801111149 cites W2035235607 @default.
- W2801111149 cites W2038073823 @default.
- W2801111149 cites W2040835861 @default.
- W2801111149 cites W2042002455 @default.
- W2801111149 cites W2042198595 @default.
- W2801111149 cites W2043659905 @default.
- W2801111149 cites W2049381049 @default.
- W2801111149 cites W2050778565 @default.
- W2801111149 cites W2054694911 @default.
- W2801111149 cites W2060483332 @default.
- W2801111149 cites W2063800686 @default.
- W2801111149 cites W2065458595 @default.
- W2801111149 cites W2069974481 @default.
- W2801111149 cites W2075451897 @default.
- W2801111149 cites W2079836636 @default.
- W2801111149 cites W2082944992 @default.
- W2801111149 cites W2083420334 @default.
- W2801111149 cites W2098148762 @default.
- W2801111149 cites W2098241186 @default.
- W2801111149 cites W2098268087 @default.
- W2801111149 cites W2098449174 @default.
- W2801111149 cites W2100738369 @default.
- W2801111149 cites W2103120598 @default.
- W2801111149 cites W2103226260 @default.
- W2801111149 cites W2105688062 @default.
- W2801111149 cites W2108859484 @default.
- W2801111149 cites W2110318148 @default.
- W2801111149 cites W2112663684 @default.
- W2801111149 cites W2114674572 @default.
- W2801111149 cites W2120403899 @default.
- W2801111149 cites W2121801043 @default.
- W2801111149 cites W2123297188 @default.
- W2801111149 cites W2123600115 @default.
- W2801111149 cites W2134206097 @default.
- W2801111149 cites W2135252099 @default.
- W2801111149 cites W2135397870 @default.
- W2801111149 cites W2135593394 @default.
- W2801111149 cites W2135697580 @default.
- W2801111149 cites W2144443529 @default.
- W2801111149 cites W2145237796 @default.
- W2801111149 cites W2145850178 @default.
- W2801111149 cites W2146194407 @default.
- W2801111149 cites W2148624349 @default.
- W2801111149 cites W2148984353 @default.
- W2801111149 cites W2155198998 @default.
- W2801111149 cites W2156747307 @default.
- W2801111149 cites W2162339585 @default.
- W2801111149 cites W2162496090 @default.
- W2801111149 cites W2163412067 @default.
- W2801111149 cites W2168123661 @default.
- W2801111149 cites W2177473494 @default.