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• W2801115369 abstract "Phosphine is the only general use fumigant for the protection of stored grain, though its long-term utility is threatened by the emergence of highly phosphine-resistant pests. Given this precarious situation, it is essential to identify factors, such as stress preconditioning, that interfere with the efficacy of phosphine fumigation. We used Caenorhabditis elegans as a model organism to test the effect of pre-exposure to heat and cold shock, UV and gamma irradiation on phosphine potency. Heat shock significantly increased tolerance to phosphine by 3-fold in wild-type nematodes, a process that was dependent on the master regulator of the heat shock response, HSF-1. Heat shock did not, however, increase the resistance of a strain carrying the phosphine resistance mutation, dld-1(wr4), and cold shock did not alter the response to phosphine of either strain. Pretreatment with the LD50 of UV (18 J cm-2) did not alter phosphine tolerance in wild-type nematodes, but the LD50 (33 J cm-2) of the phosphine resistant strain (dld-1(wr4)) doubled the level of resistance. In addition, exposure to a mild dose of gamma radiation (200 Gy) elevated the phosphine tolerance by ~2-fold in both strains." @default.
• W2801115369 created "2018-05-17" @default.
• W2801115369 creator A5014451776 @default.
• W2801115369 creator A5073704107 @default.
• W2801115369 date "2018-04-19" @default.
• W2801115369 modified "2023-10-18" @default.
• W2801115369 title "Stress pre-conditioning with temperature, UV and gamma radiation induces tolerance against phosphine toxicity" @default.
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• W2801115369 doi "https://doi.org/10.1371/journal.pone.0195349" @default.
• W2801115369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5909616" @default.
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