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- W2801116332 abstract "Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recognition task, we examined the effect of medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval in reconsolidation of competing objects memories. We found that mPFC 5-HT2aR controls retrieval and reconsolidation of object memories in the perirhinal cortex (PRH), but not in the dorsal hippocampus in rats. Also, reconsolidation of objects memories in PRH required a functional interaction between the ventral hippocampus and the mPFC. Our results indicate that in the presence of conflicting information at retrieval, mPFC 5-HT2aR may facilitate top-down context-guided control over PRH to control the behavioral response and object memory reconsolidation." @default.
- W2801116332 created "2018-05-17" @default.
- W2801116332 creator A5004382569 @default.
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- W2801116332 creator A5071959207 @default.
- W2801116332 creator A5088651051 @default.
- W2801116332 date "2018-05-02" @default.
- W2801116332 modified "2023-10-09" @default.
- W2801116332 title "5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex" @default.
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- W2801116332 doi "https://doi.org/10.7554/elife.33746" @default.
- W2801116332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5931799" @default.
- W2801116332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29717980" @default.
- W2801116332 hasPublicationYear "2018" @default.
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