Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801118112> ?p ?o ?g. }
- W2801118112 endingPage "1236" @default.
- W2801118112 startingPage "1227" @default.
- W2801118112 abstract "Contagious ecthyma (Orf) is a viral skin condition caused by a parapoxvirus. It results in cutaneous lesions that destroy the hides and skin of the infected host. In this study, the pathogenicity of Malaysian isolates of Orf virus (UPM 1/14 and UPM 2/14) was evaluated in a rat model using different inoculation sites with/without dexamethasone administration. A total of 50 rats were used in this study. For the first part of the study, 35 rats were divided into three groups; group 1 (n = 15) was inoculated with 0.5 mL of UPM 1/14 (tissue culture infective dose 50% (TCID50) 108.1/mL) while group 2 (n = 15) was inoculated with 0.5 mL of UPM 2/14 (TCID50 107.2/mL) each at the dorsum (n = 5), ear pinna (n = 5), and labial commissure (n = 5). Group 3 (n = 5) served as the control and was administered 0.5 mL of phosphate-buffered saline in all the sites mentioned above. In the second study, 15 rats were divided into three groups: a dexamethasone group (n = 5) which was given 10 mg/kg of dexamethasone once daily for 3 days, a non-dexamethasone group (n = 5), and a control (n = 5). Intradermal inoculation of 0.5 mL of UPM 1/14 was administered to each rat in the dexamethasone and non-dexamethasone groups at the dorsum, ear pinna, and labial commissure, respectively. Clinical signs and histopathological changes were evaluated for 14 days post inoculation for the first experiment and 7 days for the second experiment. Mild hyperemia was observed in the dorsum, ear pinna, and labial commissures of all inoculation groups. Group 1 (ORFV UPM 1/14) had a higher (P < 0.05) mean skin lesion score and mean stratum spinosum thickness on the labial commissure than group 2 (ORFV UPM 2/14). The dexamethasone-treated group had a higher (P < 0.05) mean skin lesion score than the non-dexamethasone group. Keratosis, acanthosis, and ballooning degeneration were the most common lesions observed in all inoculation groups. The dexamethasone-treated group had a higher (P < 0.05) mean thickness of the stratum spinosum following all inoculation sites than the non-dexamethasone group. There was no significant difference (P > 0.05) in the mean thickness of the stratum basale of the ear pinna and labial commissure between the dexamethasone and non-dexamethasone groups. Orf virus was detected by PCR from the skin tissues of rats with lesions using F1L and B2L viral genes. In conclusion, Malaysian isolates of Orf virus were seen to be mildly pathogenic to rats. The difference in inoculation sites and the induction of immune suppression were observed to present varying pathological responses in rats." @default.
- W2801118112 created "2018-05-17" @default.
- W2801118112 creator A5011703354 @default.
- W2801118112 creator A5019412751 @default.
- W2801118112 creator A5028559789 @default.
- W2801118112 creator A5037628892 @default.
- W2801118112 creator A5042425832 @default.
- W2801118112 creator A5047119251 @default.
- W2801118112 creator A5062309490 @default.
- W2801118112 creator A5074933509 @default.
- W2801118112 creator A5088949706 @default.
- W2801118112 creator A5091395775 @default.
- W2801118112 date "2018-04-22" @default.
- W2801118112 modified "2023-10-18" @default.
- W2801118112 title "Effect of dexamethasone administration on the pathogenicity and lesion severity in rats experimentally inoculated with Orf virus (Malaysian isolates)" @default.
- W2801118112 cites W1191613579 @default.
- W2801118112 cites W1511952706 @default.
- W2801118112 cites W1588114914 @default.
- W2801118112 cites W1954093507 @default.
- W2801118112 cites W1986104272 @default.
- W2801118112 cites W2002124880 @default.
- W2801118112 cites W2013980575 @default.
- W2801118112 cites W2014895004 @default.
- W2801118112 cites W2016365086 @default.
- W2801118112 cites W2057624204 @default.
- W2801118112 cites W2091184587 @default.
- W2801118112 cites W2094164838 @default.
- W2801118112 cites W2256756668 @default.
- W2801118112 cites W2321188310 @default.
- W2801118112 cites W2604727013 @default.
- W2801118112 cites W2755112125 @default.
- W2801118112 doi "https://doi.org/10.1007/s00580-018-2726-1" @default.
- W2801118112 hasPublicationYear "2018" @default.
- W2801118112 type Work @default.
- W2801118112 sameAs 2801118112 @default.
- W2801118112 citedByCount "6" @default.
- W2801118112 countsByYear W28011181122018 @default.
- W2801118112 countsByYear W28011181122019 @default.
- W2801118112 countsByYear W28011181122021 @default.
- W2801118112 countsByYear W28011181122023 @default.
- W2801118112 crossrefType "journal-article" @default.
- W2801118112 hasAuthorship W2801118112A5011703354 @default.
- W2801118112 hasAuthorship W2801118112A5019412751 @default.
- W2801118112 hasAuthorship W2801118112A5028559789 @default.
- W2801118112 hasAuthorship W2801118112A5037628892 @default.
- W2801118112 hasAuthorship W2801118112A5042425832 @default.
- W2801118112 hasAuthorship W2801118112A5047119251 @default.
- W2801118112 hasAuthorship W2801118112A5062309490 @default.
- W2801118112 hasAuthorship W2801118112A5074933509 @default.
- W2801118112 hasAuthorship W2801118112A5088949706 @default.
- W2801118112 hasAuthorship W2801118112A5091395775 @default.
- W2801118112 hasBestOaLocation W28011181122 @default.
- W2801118112 hasConcept C105702510 @default.
- W2801118112 hasConcept C126322002 @default.
- W2801118112 hasConcept C140530291 @default.
- W2801118112 hasConcept C142724271 @default.
- W2801118112 hasConcept C159047783 @default.
- W2801118112 hasConcept C180032290 @default.
- W2801118112 hasConcept C2522874641 @default.
- W2801118112 hasConcept C2777397205 @default.
- W2801118112 hasConcept C2780401358 @default.
- W2801118112 hasConcept C2781156865 @default.
- W2801118112 hasConcept C2910181907 @default.
- W2801118112 hasConcept C42972112 @default.
- W2801118112 hasConcept C71924100 @default.
- W2801118112 hasConcept C86803240 @default.
- W2801118112 hasConceptScore W2801118112C105702510 @default.
- W2801118112 hasConceptScore W2801118112C126322002 @default.
- W2801118112 hasConceptScore W2801118112C140530291 @default.
- W2801118112 hasConceptScore W2801118112C142724271 @default.
- W2801118112 hasConceptScore W2801118112C159047783 @default.
- W2801118112 hasConceptScore W2801118112C180032290 @default.
- W2801118112 hasConceptScore W2801118112C2522874641 @default.
- W2801118112 hasConceptScore W2801118112C2777397205 @default.
- W2801118112 hasConceptScore W2801118112C2780401358 @default.
- W2801118112 hasConceptScore W2801118112C2781156865 @default.
- W2801118112 hasConceptScore W2801118112C2910181907 @default.
- W2801118112 hasConceptScore W2801118112C42972112 @default.
- W2801118112 hasConceptScore W2801118112C71924100 @default.
- W2801118112 hasConceptScore W2801118112C86803240 @default.
- W2801118112 hasFunder F4320322714 @default.
- W2801118112 hasIssue "5" @default.
- W2801118112 hasLocation W28011181121 @default.
- W2801118112 hasLocation W28011181122 @default.
- W2801118112 hasOpenAccess W2801118112 @default.
- W2801118112 hasPrimaryLocation W28011181121 @default.
- W2801118112 hasRelatedWork W1981624199 @default.
- W2801118112 hasRelatedWork W2090075276 @default.
- W2801118112 hasRelatedWork W2092827529 @default.
- W2801118112 hasRelatedWork W2096709077 @default.
- W2801118112 hasRelatedWork W2132228113 @default.
- W2801118112 hasRelatedWork W2151259334 @default.
- W2801118112 hasRelatedWork W2365239112 @default.
- W2801118112 hasRelatedWork W2398647731 @default.
- W2801118112 hasRelatedWork W2404253374 @default.
- W2801118112 hasRelatedWork W2801118112 @default.
- W2801118112 hasVolume "27" @default.
- W2801118112 isParatext "false" @default.