FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801136562> ?p ?o ?g. }

• W2801136562 endingPage "91" @default.
• W2801136562 startingPage "84" @default.
• W2801136562 abstract "Over the last quarter century, a staggering number of brain imaging studies have probed the neural basis of age-related cognitive decline. Using multimodal brain imaging tools, we now have a clearer understanding of the morphological, neurochemical, and neurophysiological changes that accompany age-related declines in working memory, selective attention, inhibitory control, episodic memory and more (for review, see Cabeza, Nyberg & Park, 2016). These studies generally target adults over the age of 65, a historical precedent rooted in the average retirement age of U.S. wage-earners. An unintended consequence of this adopted standard is that it overlooks one of the most significant neuroendocrine changes in a woman’s life – the transition to menopause. In turn, it obscures our understanding of sex-dependent pathways that may shape the brain early in the aging process.The median age of menopause is 52.4 years (Gold et al., 2001). The time between the first clinical appearance of decreased ovarian function (i.e. shorter inter-menstrual time periods) to menstrual irregularity and final amenorrhea is variable and protracted, occurring over several years. The menopausal transition is marked by a decline in ovarian hormone production and is a time when many women report changes in memory and attention (e.g. “menopause fog”). Two decades of rodent and nonhuman primate studies have established the role of sex hormones in the synaptic organization of the hippocampus and prefrontal cortex (PFC), and their impact on memory function (Frick et al., 2017, Hara et al. 2015). A parallel literature has emerged within the human cognitive neuroscience field to identify the role of sex hormones in memory circuitry in the human brain. In this review, we summarize recent studies of the neural and cognitive changes that unfold in the middle decade of life (ages 45–60), as a function of sex, reproductive stage, and sex steroid hormones. As the ‘cognitive neuroscience of aging’ field evolves, applying a sex dependent lens to the study of the aging brain will enhance the translation of these findings for both sexes and ensure that men and women get the full benefit of our research efforts. By ignoring the midlife window, we risk missing critical clues that could reveal sex-dependent risk factors of future neurodegenerative disease." @default.
• W2801136562 created "2018-05-17" @default.
• W2801136562 creator A5028182980 @default.
• W2801136562 creator A5048915825 @default.
• W2801136562 date "2018-10-01" @default.
• W2801136562 modified "2023-09-29" @default.
• W2801136562 title "The middle-aged brain: biological sex and sex hormones shape memory circuitry" @default.
• W2801136562 cites W1504315435 @default.
• W2801136562 cites W1578020629 @default.
• W2801136562 cites W1760072739 @default.
• W2801136562 cites W1913092771 @default.
• W2801136562 cites W1924727730 @default.
• W2801136562 cites W1969884618 @default.
• W2801136562 cites W1970006005 @default.
• W2801136562 cites W1971984112 @default.
• W2801136562 cites W1989799361 @default.
• W2801136562 cites W1989868932 @default.
• W2801136562 cites W2001085718 @default.
• W2801136562 cites W2001462170 @default.
• W2801136562 cites W2004371621 @default.
• W2801136562 cites W2005356261 @default.
• W2801136562 cites W2012139755 @default.
• W2801136562 cites W2018187876 @default.
• W2801136562 cites W2019249853 @default.
• W2801136562 cites W2023482999 @default.
• W2801136562 cites W2024630005 @default.
• W2801136562 cites W2026463002 @default.
• W2801136562 cites W2027370169 @default.
• W2801136562 cites W2041405064 @default.
• W2801136562 cites W2044985390 @default.
• W2801136562 cites W2045645123 @default.
• W2801136562 cites W2053389846 @default.
• W2801136562 cites W2061195971 @default.
• W2801136562 cites W2061847541 @default.
• W2801136562 cites W2063101137 @default.
• W2801136562 cites W2066844700 @default.
• W2801136562 cites W2067211004 @default.
• W2801136562 cites W2069827651 @default.
• W2801136562 cites W2077725650 @default.
• W2801136562 cites W2079637016 @default.
• W2801136562 cites W2081016707 @default.
• W2801136562 cites W2081322741 @default.
• W2801136562 cites W2085386918 @default.
• W2801136562 cites W2089725106 @default.
• W2801136562 cites W2096966803 @default.
• W2801136562 cites W2098662651 @default.
• W2801136562 cites W2102653525 @default.
• W2801136562 cites W2104163310 @default.
• W2801136562 cites W2107213733 @default.
• W2801136562 cites W2108434913 @default.
• W2801136562 cites W2119453754 @default.
• W2801136562 cites W2131266318 @default.
• W2801136562 cites W2135356926 @default.
• W2801136562 cites W2136231442 @default.
• W2801136562 cites W2139581313 @default.
• W2801136562 cites W2141687868 @default.
• W2801136562 cites W2144317269 @default.
• W2801136562 cites W2146736618 @default.
• W2801136562 cites W2149487349 @default.
• W2801136562 cites W2153979740 @default.
• W2801136562 cites W2156284662 @default.
• W2801136562 cites W2161220328 @default.
• W2801136562 cites W2162527657 @default.
• W2801136562 cites W2203314189 @default.
• W2801136562 cites W2257914755 @default.
• W2801136562 cites W2279400264 @default.
• W2801136562 cites W2372642502 @default.
• W2801136562 cites W2441051753 @default.
• W2801136562 cites W2465155672 @default.
• W2801136562 cites W2505372533 @default.
• W2801136562 cites W2507664632 @default.
• W2801136562 cites W2525826998 @default.
• W2801136562 cites W2529027487 @default.
• W2801136562 cites W2547697407 @default.
• W2801136562 cites W2550678493 @default.
• W2801136562 cites W2571234872 @default.
• W2801136562 cites W2580903444 @default.
• W2801136562 cites W2600519085 @default.
• W2801136562 cites W2605240888 @default.
• W2801136562 cites W2607440066 @default.
• W2801136562 cites W2623691 @default.
• W2801136562 cites W2739554745 @default.
• W2801136562 cites W2751705769 @default.
• W2801136562 cites W2771119295 @default.
• W2801136562 cites W2787895246 @default.
• W2801136562 cites W2904831407 @default.
• W2801136562 cites W415286823 @default.
• W2801136562 cites W4376849352 @default.
• W2801136562 cites W817042229 @default.
• W2801136562 cites W928391995 @default.
• W2801136562 doi "https://doi.org/10.1016/j.cobeha.2018.03.009" @default.
• W2801136562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157917" @default.
• W2801136562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271832" @default.
• W2801136562 hasPublicationYear "2018" @default.
• W2801136562 type Work @default.
• W2801136562 sameAs 2801136562 @default.
• W2801136562 citedByCount "25" @default.
• W2801136562 countsByYear W28011365622018 @default.

• next