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• W2801152408 endingPage "1544" @default.
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• W2801152408 abstract "MicroRNAs (miRNAs) are small, non-coding RNAs that affect the post-transcriptional regulation of a variety of biological pathways. A previous study found out that miR-200b was important in the metabolism of obesity, but the mechanism of miR-200b regulateing adipogenesis is not fully understood.. In the present study, we observed that miR200b expression decreased both in obese mice and during the process of 3T3-L1 adipogenic differentiation. Overexpression of miR-200b promoted adipocyte proliferation by regulating the expression of cell cycle-regulated factors.Furthermore, overexpression of miR-200b reduced lipid accumulation and triglyceride content in adipocytes, and accompanied by a marked decrease in the expression of adipocyte-specific genes involved in fatty acid synthesis. Luciferase activity assays confirmed that miR-200b regulated adipocyte differentiation by directly targeting KLF4, and miR-200b suppressed the expression of KLF4 in both mRNA level and protein level. Moreover, the expression levels of downstream genes of KLF4, such as C/EBPβ, C/EBPα, KLF5 and PPARγ, were decreased in 3T3-L1 cells by miR-200b overexpression. Taken together, these results indicate that miR-200b may be involved in adipogenesis and could be a target for therapeutic intervention in obesity and metabolic syndrome." @default.
• W2801152408 created "2018-05-17" @default.
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• W2801152408 date "2018-07-01" @default.
• W2801152408 modified "2023-09-26" @default.
• W2801152408 title "MicroRNA-200b regulates preadipocyte proliferation and differentiation by targeting KLF4" @default.
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• W2801152408 doi "https://doi.org/10.1016/j.biopha.2018.04.170" @default.
• W2801152408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29864940" @default.
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