FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801155306> ?p ?o ?g. }

• W2801155306 endingPage "618" @default.
• W2801155306 startingPage "604" @default.
• W2801155306 abstract "Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA). Zofenopril demonstrated its superiority over ramipril in reducing the combined occurrence of death or hospitalization for cardiovascular causes both in the overall population included in the original study and in subgroups of patients at highest risk, namely hypertensive and diabetic subjects. The effects of the early treatment with zofenopril were sustained over time, and, after 5 years of follow-up, zofenopril increased the survival likelihood and reduced the hospitalization rate. Compared to ramipril, zofenopril was cost-effective with a number to treat of 13 and an incremental cost-effectiveness ratio (ICER) of 2125.45 euros for any additional event prevented. Furthermore, in real-world settings, zofenopril decreased the risk of death in patients with heart failure, particularly in men, and in subjects older than 76 years or with ejection fraction lower than 54%. These results support the early use of zofenopril immediately after AMI, even in the presence of comorbidities, and its maintenance over time to reduce the risk of heart failure. Funding: Menarini International Operations Luxembourg S.A." @default.
• W2801155306 created "2018-05-17" @default.
• W2801155306 creator A5009318704 @default.
• W2801155306 creator A5011747612 @default.
• W2801155306 creator A5036209306 @default.
• W2801155306 creator A5052505304 @default.
• W2801155306 creator A5055457360 @default.
• W2801155306 creator A5081983016 @default.
• W2801155306 date "2018-04-17" @default.
• W2801155306 modified "2023-10-12" @default.
• W2801155306 title "Efficacy and Safety of Zofenopril Versus Ramipril in the Treatment of Myocardial Infarction and Heart Failure: A Review of the Published and Unpublished Data of the Randomized Double-Blind SMILE-4 Study" @default.
• W2801155306 cites W1499839181 @default.
• W2801155306 cites W1504007488 @default.
• W2801155306 cites W1836189764 @default.
• W2801155306 cites W1966133551 @default.
• W2801155306 cites W2000013140 @default.
• W2801155306 cites W2007778010 @default.
• W2801155306 cites W2012997098 @default.
• W2801155306 cites W2013518852 @default.
• W2801155306 cites W2022957677 @default.
• W2801155306 cites W2041750922 @default.
• W2801155306 cites W2049382616 @default.
• W2801155306 cites W2053820193 @default.
• W2801155306 cites W2064320873 @default.
• W2801155306 cites W2065853583 @default.
• W2801155306 cites W2067140776 @default.
• W2801155306 cites W2073379414 @default.
• W2801155306 cites W2076953572 @default.
• W2801155306 cites W2084632272 @default.
• W2801155306 cites W2097424645 @default.
• W2801155306 cites W2101099004 @default.
• W2801155306 cites W2104437520 @default.
• W2801155306 cites W2118116306 @default.
• W2801155306 cites W2122512705 @default.
• W2801155306 cites W2124659021 @default.
• W2801155306 cites W2126930857 @default.
• W2801155306 cites W2137087929 @default.
• W2801155306 cites W2145318712 @default.
• W2801155306 cites W2157476464 @default.
• W2801155306 cites W2164611317 @default.
• W2801155306 cites W2260813483 @default.
• W2801155306 cites W2275634847 @default.
• W2801155306 cites W2323549932 @default.
• W2801155306 cites W2462958992 @default.
• W2801155306 cites W2527877826 @default.
• W2801155306 cites W2588321989 @default.
• W2801155306 cites W51911325 @default.
• W2801155306 cites W2166189719 @default.
• W2801155306 doi "https://doi.org/10.1007/s12325-018-0697-x" @default.
• W2801155306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5960496" @default.
• W2801155306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29667144" @default.
• W2801155306 hasPublicationYear "2018" @default.
• W2801155306 type Work @default.
• W2801155306 sameAs 2801155306 @default.
• W2801155306 citedByCount "16" @default.
• W2801155306 countsByYear W28011553062018 @default.
• W2801155306 countsByYear W28011553062019 @default.
• W2801155306 countsByYear W28011553062020 @default.
• W2801155306 countsByYear W28011553062021 @default.
• W2801155306 countsByYear W28011553062022 @default.
• W2801155306 countsByYear W28011553062023 @default.
• W2801155306 crossrefType "journal-article" @default.
• W2801155306 hasAuthorship W2801155306A5009318704 @default.
• W2801155306 hasAuthorship W2801155306A5011747612 @default.
• W2801155306 hasAuthorship W2801155306A5036209306 @default.
• W2801155306 hasAuthorship W2801155306A5052505304 @default.
• W2801155306 hasAuthorship W2801155306A5055457360 @default.
• W2801155306 hasAuthorship W2801155306A5081983016 @default.
• W2801155306 hasBestOaLocation W28011553061 @default.
• W2801155306 hasConcept C126322002 @default.
• W2801155306 hasConcept C164705383 @default.
• W2801155306 hasConcept C168563851 @default.
• W2801155306 hasConcept C207103383 @default.
• W2801155306 hasConcept C2778198053 @default.
• W2801155306 hasConcept C2779888176 @default.
• W2801155306 hasConcept C2908647359 @default.
• W2801155306 hasConcept C44249647 @default.
• W2801155306 hasConcept C500558357 @default.
• W2801155306 hasConcept C71924100 @default.
• W2801155306 hasConcept C78085059 @default.
• W2801155306 hasConcept C84393581 @default.
• W2801155306 hasConcept C99454951 @default.
• W2801155306 hasConceptScore W2801155306C126322002 @default.
• W2801155306 hasConceptScore W2801155306C164705383 @default.
• W2801155306 hasConceptScore W2801155306C168563851 @default.
• W2801155306 hasConceptScore W2801155306C207103383 @default.
• W2801155306 hasConceptScore W2801155306C2778198053 @default.
• W2801155306 hasConceptScore W2801155306C2779888176 @default.
• W2801155306 hasConceptScore W2801155306C2908647359 @default.
• W2801155306 hasConceptScore W2801155306C44249647 @default.
• W2801155306 hasConceptScore W2801155306C500558357 @default.
• W2801155306 hasConceptScore W2801155306C71924100 @default.
• W2801155306 hasConceptScore W2801155306C78085059 @default.
• W2801155306 hasConceptScore W2801155306C84393581 @default.
• W2801155306 hasConceptScore W2801155306C99454951 @default.
• W2801155306 hasIssue "5" @default.
• W2801155306 hasLocation W28011553061 @default.
• W2801155306 hasLocation W28011553062 @default.

• next