Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801160882> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2801160882 endingPage "60" @default.
- W2801160882 startingPage "54" @default.
- W2801160882 abstract "Here we evaluate a multiplicative (relative) risk model for improved cancer risk estimation of genotoxic compounds. According to this model, cancer risk is proportional to the background tumor incidence and to the internal dose of the genotoxic compound. Furthermore, the relative risk coefficient per internal dose is considered to be approximately the same across tumor sites, sex, and species. In the present study, we demonstrate that the relative risk model is valid for cancer risk estimation of glycidol, a common food contaminant. Published tumor data from glycidol carcinogenicity studies in mice and rats were evaluated in combination with internal dose estimates from hemoglobin adduct measurements in blood from mice and rats treated with glycidol in short-term studies. A good agreement between predicted and observed tumor incidence in responding sites was demonstrated in the animals, supporting a relative risk coefficient that is independent of tumor site, sex, and species. There was no significant difference between the risk coefficients for mice (5.1% per mMh) and rats (5.4% per mMh) when considering internal doses of glycidol. Altogether, this mechanism-based risk model gives a reliable risk coefficient, which then was extrapolated to humans considering internal dose, and background cancer incidence." @default.
- W2801160882 created "2018-05-17" @default.
- W2801160882 creator A5004806882 @default.
- W2801160882 creator A5016045810 @default.
- W2801160882 creator A5071307673 @default.
- W2801160882 date "2019-06-01" @default.
- W2801160882 modified "2023-10-03" @default.
- W2801160882 title "Cancer risk estimation of glycidol based on rodent carcinogenicity studies, a multiplicative risk model and in vivo dosimetry" @default.
- W2801160882 cites W1963634283 @default.
- W2801160882 cites W1974137987 @default.
- W2801160882 cites W1975166861 @default.
- W2801160882 cites W1998487163 @default.
- W2801160882 cites W2009669294 @default.
- W2801160882 cites W2017816297 @default.
- W2801160882 cites W2019078072 @default.
- W2801160882 cites W2024805816 @default.
- W2801160882 cites W2039153047 @default.
- W2801160882 cites W2042343092 @default.
- W2801160882 cites W2064490984 @default.
- W2801160882 cites W2092779845 @default.
- W2801160882 cites W2098990836 @default.
- W2801160882 cites W2135011298 @default.
- W2801160882 cites W2138649409 @default.
- W2801160882 cites W2150381231 @default.
- W2801160882 cites W2153938521 @default.
- W2801160882 cites W2170757897 @default.
- W2801160882 cites W2336252898 @default.
- W2801160882 cites W2418665003 @default.
- W2801160882 cites W2566354171 @default.
- W2801160882 cites W2604024577 @default.
- W2801160882 cites W2802427296 @default.
- W2801160882 cites W4234575844 @default.
- W2801160882 cites W4253896471 @default.
- W2801160882 doi "https://doi.org/10.1016/j.fct.2019.03.037" @default.
- W2801160882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30914355" @default.
- W2801160882 hasPublicationYear "2019" @default.
- W2801160882 type Work @default.
- W2801160882 sameAs 2801160882 @default.
- W2801160882 citedByCount "7" @default.
- W2801160882 countsByYear W28011608822019 @default.
- W2801160882 countsByYear W28011608822020 @default.
- W2801160882 countsByYear W28011608822021 @default.
- W2801160882 countsByYear W28011608822022 @default.
- W2801160882 countsByYear W28011608822023 @default.
- W2801160882 crossrefType "journal-article" @default.
- W2801160882 hasAuthorship W2801160882A5004806882 @default.
- W2801160882 hasAuthorship W2801160882A5016045810 @default.
- W2801160882 hasAuthorship W2801160882A5071307673 @default.
- W2801160882 hasBestOaLocation W28011608821 @default.
- W2801160882 hasConcept C114246631 @default.
- W2801160882 hasConcept C121608353 @default.
- W2801160882 hasConcept C126322002 @default.
- W2801160882 hasConcept C143998085 @default.
- W2801160882 hasConcept C161790260 @default.
- W2801160882 hasConcept C185592680 @default.
- W2801160882 hasConcept C2781326009 @default.
- W2801160882 hasConcept C33070731 @default.
- W2801160882 hasConcept C44249647 @default.
- W2801160882 hasConcept C55493867 @default.
- W2801160882 hasConcept C71924100 @default.
- W2801160882 hasConcept C82789193 @default.
- W2801160882 hasConcept C86803240 @default.
- W2801160882 hasConceptScore W2801160882C114246631 @default.
- W2801160882 hasConceptScore W2801160882C121608353 @default.
- W2801160882 hasConceptScore W2801160882C126322002 @default.
- W2801160882 hasConceptScore W2801160882C143998085 @default.
- W2801160882 hasConceptScore W2801160882C161790260 @default.
- W2801160882 hasConceptScore W2801160882C185592680 @default.
- W2801160882 hasConceptScore W2801160882C2781326009 @default.
- W2801160882 hasConceptScore W2801160882C33070731 @default.
- W2801160882 hasConceptScore W2801160882C44249647 @default.
- W2801160882 hasConceptScore W2801160882C55493867 @default.
- W2801160882 hasConceptScore W2801160882C71924100 @default.
- W2801160882 hasConceptScore W2801160882C82789193 @default.
- W2801160882 hasConceptScore W2801160882C86803240 @default.
- W2801160882 hasFunder F4320321033 @default.
- W2801160882 hasFunder F4320322315 @default.
- W2801160882 hasFunder F4320325669 @default.
- W2801160882 hasLocation W28011608821 @default.
- W2801160882 hasLocation W28011608822 @default.
- W2801160882 hasOpenAccess W2801160882 @default.
- W2801160882 hasPrimaryLocation W28011608821 @default.
- W2801160882 hasRelatedWork W2029862005 @default.
- W2801160882 hasRelatedWork W2091020218 @default.
- W2801160882 hasRelatedWork W2365364931 @default.
- W2801160882 hasRelatedWork W2405792064 @default.
- W2801160882 hasRelatedWork W2408800009 @default.
- W2801160882 hasRelatedWork W2418638721 @default.
- W2801160882 hasRelatedWork W2748952813 @default.
- W2801160882 hasRelatedWork W2897496508 @default.
- W2801160882 hasRelatedWork W2899084033 @default.
- W2801160882 hasRelatedWork W2496978074 @default.
- W2801160882 hasVolume "128" @default.
- W2801160882 isParatext "false" @default.
- W2801160882 isRetracted "false" @default.
- W2801160882 magId "2801160882" @default.
- W2801160882 workType "article" @default.