FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801161821> ?p ?o ?g. }

• W2801161821 abstract "Background: Adiponectin has been proposed as a biomarker of disease severity and progression in chronic obstructive pulmonary disease (COPD) and associated with spirometry-defined COPD and with computed tomography (CT)-measured emphysema. Increased adiponectin plays a role in other diseases including diabetes/metabolic syndrome, cardiovascular disease and osteoporosis. Previous studies of adiponectin and COPD have not assessed the relationship of adiponectin to airway disease in smokers and have not evaluated the effect of other comorbid diseases on the relationship of adiponectin and lung disease. We postulated that adiponectin levels would associate with both airway disease and emphysema in smokers with and without COPD, and further postulated that body composition and the comorbid diseases of osteoporosis, cardiovascular disease and diabetes might influence adiponectin levels. Methods: Current and former smokers from the COPD Genetic Epidemiology study (COPDGene) (n= 424) were assigned to 4 groups based on CT lung characteristics and volumetric Bone Density (vBMD). Emphysema (% low attenuation area at -950) and airway disease (Wall area %) were used to assess smoking-related lung disease (SRLD). Group 1) Normal Lung with Normal vBMD; Group 2) Normal Lung and Osteoporosis; Group 3) SRLD with Normal vBMD; Group 4) SRLD with Osteoporosis. Cardiovascular disease (CVD), diabetes, C-reactive protein (CRP) and T-cadherin (soluble receptor for adiponectin) levels were defined for each group. Body composition was derived from chest CT. Multivariable regression assessed effects of emphysema, wall area %, bone density, comorbid diseases and other key factors on log adiponectin. Results: Group 4, SRLD with Osteoporosis, had significantly higher adiponectin levels compared to other groups and the effect persisted in adjusted models. Systemic inflammation (by CRP) was associated with SRLD in Groups 3 and 4 but not with osteoporosis alone. In regression models, lower bone density and worse emphysema were associated with higher adiponectin. Airway disease was associated with higher adiponectin levels when T-cadherin was added to the model. Male gender, greater muscle and fat were associated with lower adiponectin. Conclusions: Adiponectin is increased with both airway disease and emphysema in smokers. Bone density, and fat and muscle composition are all significant factors predicting adiponectin that should be considered when it is used as a biomarker of COPD. Increased adiponectin from chronic inflammation may play a role in the progression of bone loss in COPD and other lung diseases." @default.
• W2801161821 created "2018-05-17" @default.
• W2801161821 creator A5001253697 @default.
• W2801161821 creator A5013660491 @default.
• W2801161821 creator A5017665414 @default.
• W2801161821 creator A5018495347 @default.
• W2801161821 creator A5023897162 @default.
• W2801161821 creator A5029870208 @default.
• W2801161821 creator A5034728621 @default.
• W2801161821 creator A5050358373 @default.
• W2801161821 creator A5051715657 @default.
• W2801161821 creator A5064775862 @default.
• W2801161821 creator A5068749992 @default.
• W2801161821 creator A5082385395 @default.
• W2801161821 date "2018-01-01" @default.
• W2801161821 modified "2023-09-29" @default.
• W2801161821 title "Lung, Fat and Bone: Increased Adiponectin Associates with the Combination of Smoking-Related Lung Disease and Osteoporosis" @default.
• W2801161821 cites W1609604630 @default.
• W2801161821 cites W1868482330 @default.
• W2801161821 cites W1995869526 @default.
• W2801161821 cites W1997556041 @default.
• W2801161821 cites W2003808211 @default.
• W2801161821 cites W2010047567 @default.
• W2801161821 cites W2012077487 @default.
• W2801161821 cites W2031207391 @default.
• W2801161821 cites W2045711464 @default.
• W2801161821 cites W2047841158 @default.
• W2801161821 cites W2050080529 @default.
• W2801161821 cites W2052771311 @default.
• W2801161821 cites W2063814384 @default.
• W2801161821 cites W2068563436 @default.
• W2801161821 cites W2080551137 @default.
• W2801161821 cites W2082673878 @default.
• W2801161821 cites W2082907106 @default.
• W2801161821 cites W2095022880 @default.
• W2801161821 cites W2095918859 @default.
• W2801161821 cites W2096780937 @default.
• W2801161821 cites W2096866702 @default.
• W2801161821 cites W2099692602 @default.
• W2801161821 cites W2099696411 @default.
• W2801161821 cites W2122493940 @default.
• W2801161821 cites W2126502326 @default.
• W2801161821 cites W2130509783 @default.
• W2801161821 cites W2141491687 @default.
• W2801161821 cites W2142096203 @default.
• W2801161821 cites W2153215002 @default.
• W2801161821 cites W2153279335 @default.
• W2801161821 cites W2155186970 @default.
• W2801161821 cites W2155786049 @default.
• W2801161821 cites W2156489014 @default.
• W2801161821 cites W2163678936 @default.
• W2801161821 cites W2172055936 @default.
• W2801161821 cites W2610204288 @default.
• W2801161821 cites W2917600742 @default.
• W2801161821 cites W67409937 @default.
• W2801161821 doi "https://doi.org/10.15326/jcopdf.5.2.2016.0174" @default.
• W2801161821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6190517" @default.
• W2801161821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30374451" @default.
• W2801161821 hasPublicationYear "2018" @default.
• W2801161821 type Work @default.
• W2801161821 sameAs 2801161821 @default.
• W2801161821 citedByCount "3" @default.
• W2801161821 countsByYear W28011618212019 @default.
• W2801161821 countsByYear W28011618212023 @default.
• W2801161821 crossrefType "journal-article" @default.
• W2801161821 hasAuthorship W2801161821A5001253697 @default.
• W2801161821 hasAuthorship W2801161821A5013660491 @default.
• W2801161821 hasAuthorship W2801161821A5017665414 @default.
• W2801161821 hasAuthorship W2801161821A5018495347 @default.
• W2801161821 hasAuthorship W2801161821A5023897162 @default.
• W2801161821 hasAuthorship W2801161821A5029870208 @default.
• W2801161821 hasAuthorship W2801161821A5034728621 @default.
• W2801161821 hasAuthorship W2801161821A5050358373 @default.
• W2801161821 hasAuthorship W2801161821A5051715657 @default.
• W2801161821 hasAuthorship W2801161821A5064775862 @default.
• W2801161821 hasAuthorship W2801161821A5068749992 @default.
• W2801161821 hasAuthorship W2801161821A5082385395 @default.
• W2801161821 hasBestOaLocation W28011618211 @default.
• W2801161821 hasConcept C126322002 @default.
• W2801161821 hasConcept C134018914 @default.
• W2801161821 hasConcept C2776042228 @default.
• W2801161821 hasConcept C2776541429 @default.
• W2801161821 hasConcept C2776780178 @default.
• W2801161821 hasConcept C2776782570 @default.
• W2801161821 hasConcept C2777391703 @default.
• W2801161821 hasConcept C2779329777 @default.
• W2801161821 hasConcept C2780333948 @default.
• W2801161821 hasConcept C555293320 @default.
• W2801161821 hasConcept C71924100 @default.
• W2801161821 hasConceptScore W2801161821C126322002 @default.
• W2801161821 hasConceptScore W2801161821C134018914 @default.
• W2801161821 hasConceptScore W2801161821C2776042228 @default.
• W2801161821 hasConceptScore W2801161821C2776541429 @default.
• W2801161821 hasConceptScore W2801161821C2776780178 @default.
• W2801161821 hasConceptScore W2801161821C2776782570 @default.
• W2801161821 hasConceptScore W2801161821C2777391703 @default.
• W2801161821 hasConceptScore W2801161821C2779329777 @default.
• W2801161821 hasConceptScore W2801161821C2780333948 @default.
• W2801161821 hasConceptScore W2801161821C555293320 @default.
• W2801161821 hasConceptScore W2801161821C71924100 @default.

• next