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• W2801162107 endingPage "e018471" @default.
• W2801162107 startingPage "e018471" @default.
• W2801162107 abstract "Introduction Osteoarthritis (OA) of the knee is characterised by knee pain, disability and degenerative changes, and places a burden on societies all over the world. Exercise therapy is an often-used modality, but there is little evidence of what type of exercise dose is the most effective, indicating a need for controlled studies of the effect of different dosages. Thus, the aim of the study described in this protocol is to evaluate the effects of high-dose versus low-dose medical exercise therapy (MET) in patients with knee OA. Methods and analysis This is a multicentre prospective randomised two-arm trial with blinded assessment and data analysis. We are planning to include 200 patients aged 45–85 years with symptomatic (pain and decreased functioning) and X-ray verified diagnosis of knee OA. Those eligible for participation will be randomly allocated to either high-dose (n=100) or low-dose (n=100) MET. All patients receive three supervised treatments each week for 12 weeks, giving a total of 36 MET sessions. The high-dose group exercises for 70–90 min compared with 20–30 min for the low-dose group. The high-dose group exercises for a longer time, and receives a greater number of exercises with more repetitions and sets. Background and outcome variables are recorded at inclusion, and outcome measures are collected after every sixth treatment, at the end of treatment, and at 6-month and 12-month follow-ups. Primary outcome is self-rated knee functioning and pain using the Knee Injury and Osteoarthritis Outcome Score (KOOS). The primary end point is at the end of treatment after 3 months, and secondary end points are at 6 months and 12 months after the end of treatment. Ethics and dissemination This project has been approved by the Regional Research Ethics Committees in Stockholm, Sweden, and in Norway. Our results will be submitted to peer-reviewed journals and presented at national and international conferences. Trial registration number NCT02024126" @default.
• W2801162107 created "2018-05-17" @default.
• W2801162107 creator A5022834511 @default.
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• W2801162107 creator A5083520087 @default.
• W2801162107 date "2018-05-01" @default.
• W2801162107 modified "2023-10-04" @default.
• W2801162107 title "How does exercise dose affect patients with long-term osteoarthritis of the knee? A study protocol of a randomised controlled trial in Sweden and Norway: the SWENOR Study" @default.
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• W2801162107 doi "https://doi.org/10.1136/bmjopen-2017-018471" @default.
• W2801162107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5942416" @default.
• W2801162107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29730615" @default.

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