Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801163406> ?p ?o ?g. }
- W2801163406 endingPage "50" @default.
- W2801163406 startingPage "40" @default.
- W2801163406 abstract "Part of clinically applicable bone graft substitutes are developed by using mechanical stimulation of flow-perfusion into cell-seeded scaffolds. The role of fluid flow is crucial in driving the nutrient to seeded cells and in stimulating cell colonization. A common numerical approach is to use a multiscale model to link some physical quantities (wall shear stress and inlet flow rate) that act at different scales. In this study, a multiscale model is developed in order to determine the optimal inlet flow rate to cultivate osteoblast-like cells seeded in a controlled macroporous biomaterial inside a perfusion bioreactor system. We focus particularly on the influence of Wall Shear Stress on cell colonization to predict cell colonization at the macroscale. Results obtained at the microscale are interpolated at the macroscale to determine the optimal flow rate. For a macroporous scaffold made of interconnected pores with pore diameters of above 350 μm and interconnection diameters of 150 μm, the model predicts a cell colonization of 325% after a 7-day-cell culture with a constant inlet flow rate of 0.69 mL·min−1. Furthermore, the strength of this protocol is the possibility to adapt it to most porous biomaterials and dynamic cell culture systems." @default.
- W2801163406 created "2018-05-17" @default.
- W2801163406 creator A5005980104 @default.
- W2801163406 creator A5022772799 @default.
- W2801163406 creator A5065011311 @default.
- W2801163406 creator A5073047392 @default.
- W2801163406 creator A5076781414 @default.
- W2801163406 creator A5088386716 @default.
- W2801163406 date "2018-07-01" @default.
- W2801163406 modified "2023-10-10" @default.
- W2801163406 title "Numerical optimization of cell colonization modelling inside scaffold for perfusion bioreactor: A multiscale model" @default.
- W2801163406 cites W1480764297 @default.
- W2801163406 cites W1572684683 @default.
- W2801163406 cites W1853821483 @default.
- W2801163406 cites W1926704856 @default.
- W2801163406 cites W1938952532 @default.
- W2801163406 cites W1963558489 @default.
- W2801163406 cites W1968738869 @default.
- W2801163406 cites W1970482680 @default.
- W2801163406 cites W1972349420 @default.
- W2801163406 cites W1985229642 @default.
- W2801163406 cites W1986349994 @default.
- W2801163406 cites W1986737698 @default.
- W2801163406 cites W1988054515 @default.
- W2801163406 cites W1988236713 @default.
- W2801163406 cites W1988447859 @default.
- W2801163406 cites W1990062901 @default.
- W2801163406 cites W2009270745 @default.
- W2801163406 cites W2028158246 @default.
- W2801163406 cites W2029920142 @default.
- W2801163406 cites W2030663143 @default.
- W2801163406 cites W2036912612 @default.
- W2801163406 cites W2037627864 @default.
- W2801163406 cites W2041897038 @default.
- W2801163406 cites W2048395168 @default.
- W2801163406 cites W2053332945 @default.
- W2801163406 cites W2054250293 @default.
- W2801163406 cites W2054948570 @default.
- W2801163406 cites W2057991615 @default.
- W2801163406 cites W2065051087 @default.
- W2801163406 cites W2066989622 @default.
- W2801163406 cites W2068462201 @default.
- W2801163406 cites W2070971402 @default.
- W2801163406 cites W2080386358 @default.
- W2801163406 cites W2080938625 @default.
- W2801163406 cites W2082528980 @default.
- W2801163406 cites W2085834775 @default.
- W2801163406 cites W2086269269 @default.
- W2801163406 cites W2087380272 @default.
- W2801163406 cites W2088846982 @default.
- W2801163406 cites W2092037051 @default.
- W2801163406 cites W2095098540 @default.
- W2801163406 cites W2100334671 @default.
- W2801163406 cites W2104963758 @default.
- W2801163406 cites W2111095877 @default.
- W2801163406 cites W2111415695 @default.
- W2801163406 cites W2114013702 @default.
- W2801163406 cites W2115484826 @default.
- W2801163406 cites W2119395547 @default.
- W2801163406 cites W2123521967 @default.
- W2801163406 cites W2127119921 @default.
- W2801163406 cites W2129086150 @default.
- W2801163406 cites W2130653190 @default.
- W2801163406 cites W2131907798 @default.
- W2801163406 cites W2141653639 @default.
- W2801163406 cites W2149562261 @default.
- W2801163406 cites W2154148361 @default.
- W2801163406 cites W2155836134 @default.
- W2801163406 cites W2169700988 @default.
- W2801163406 cites W2205111793 @default.
- W2801163406 cites W2230487954 @default.
- W2801163406 cites W2262345939 @default.
- W2801163406 cites W2353569777 @default.
- W2801163406 cites W2415663409 @default.
- W2801163406 cites W2488980006 @default.
- W2801163406 cites W2565252710 @default.
- W2801163406 cites W2750465599 @default.
- W2801163406 doi "https://doi.org/10.1016/j.medengphy.2018.04.012" @default.
- W2801163406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29753628" @default.
- W2801163406 hasPublicationYear "2018" @default.
- W2801163406 type Work @default.
- W2801163406 sameAs 2801163406 @default.
- W2801163406 citedByCount "11" @default.
- W2801163406 countsByYear W28011634062019 @default.
- W2801163406 countsByYear W28011634062020 @default.
- W2801163406 countsByYear W28011634062021 @default.
- W2801163406 countsByYear W28011634062023 @default.
- W2801163406 crossrefType "journal-article" @default.
- W2801163406 hasAuthorship W2801163406A5005980104 @default.
- W2801163406 hasAuthorship W2801163406A5022772799 @default.
- W2801163406 hasAuthorship W2801163406A5065011311 @default.
- W2801163406 hasAuthorship W2801163406A5073047392 @default.
- W2801163406 hasAuthorship W2801163406A5076781414 @default.
- W2801163406 hasAuthorship W2801163406A5088386716 @default.
- W2801163406 hasBestOaLocation W28011634062 @default.
- W2801163406 hasConcept C121332964 @default.
- W2801163406 hasConcept C127413603 @default.
- W2801163406 hasConcept C136229726 @default.