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• W2801165219 endingPage "e1006060" @default.
• W2801165219 startingPage "e1006060" @default.
• W2801165219 abstract "Iron plays vital roles in the human body including enzymatic processes, oxygen-transport via hemoglobin and immune response. Iron metabolism is characterized by ~95% recycling and minor replenishment through diet. Anemia of chronic kidney disease (CKD) is characterized by a lack of synthesis of erythropoietin leading to reduced red blood cell (RBC) formation and aberrant iron recycling. Treatment of CKD anemia aims to normalize RBC count and serum hemoglobin. Clinically, the various fluxes of iron transport and accumulation are not measured so that changes during disease (e.g., CKD) and treatment are unknown. Unwanted iron accumulation in patients is known to lead to adverse effects. Current whole-body models lack the mechanistic details of iron transport related to RBC maturation, transferrin (Tf and TfR) dynamics and assume passive iron efflux from macrophages. Hence, they are not predictive of whole-body iron dynamics and cannot be used to design individualized patient treatment. For prediction, we developed a mechanistic, multi-scale computational model of whole-body iron metabolism incorporating four compartments containing major pools of iron and RBC generation process. The model accounts for multiple forms of iron in vivo, mechanisms involved in iron uptake and release and their regulation. Furthermore, the model is interfaced with drug pharmacokinetics to allow simulation of treatment dynamics. We calibrated our model with experimental and clinical data from peer-reviewed literature to reliably simulate CKD anemia and the effects of current treatment involving combination of epoietin-alpha and iron dextran. This in silico whole-body model of iron metabolism predicts that a year of treatment can potentially lead to 90% downregulation of ferroportin (FPN) levels, 15-fold increase in iron stores with only a 20% increase in iron flux from the reticulo-endothelial system (RES). Model simulations quantified unmeasured iron fluxes, previously unknown effects of treatment on FPN-level and iron stores in the RES. This mechanistic whole-body model can be the basis for future studies that incorporate iron metabolism together with related clinical experiments. Such an approach could pave the way for development of effective personalized treatment of CKD anemia." @default.
• W2801165219 created "2018-05-17" @default.
• W2801165219 creator A5005301360 @default.
• W2801165219 creator A5017176596 @default.
• W2801165219 creator A5050315994 @default.
• W2801165219 date "2018-04-16" @default.
• W2801165219 modified "2023-10-01" @default.
• W2801165219 title "Whole-body iron transport and metabolism: Mechanistic, multi-scale model to improve treatment of anemia in chronic kidney disease" @default.
• W2801165219 cites W109599821 @default.
• W2801165219 cites W110044107 @default.
• W2801165219 cites W1496550987 @default.
• W2801165219 cites W1515497590 @default.
• W2801165219 cites W1520189306 @default.
• W2801165219 cites W1565446694 @default.
• W2801165219 cites W1567182672 @default.
• W2801165219 cites W1590944751 @default.
• W2801165219 cites W1608904542 @default.
• W2801165219 cites W1774553236 @default.
• W2801165219 cites W1963859554 @default.
• W2801165219 cites W1964685535 @default.
• W2801165219 cites W1971437815 @default.
• W2801165219 cites W1974171150 @default.
• W2801165219 cites W1979621257 @default.
• W2801165219 cites W1980042430 @default.
• W2801165219 cites W1982300107 @default.
• W2801165219 cites W1986296275 @default.
• W2801165219 cites W1989331670 @default.
• W2801165219 cites W1989771080 @default.
• W2801165219 cites W1989788693 @default.
• W2801165219 cites W1993691862 @default.
• W2801165219 cites W1997302887 @default.
• W2801165219 cites W1999149952 @default.
• W2801165219 cites W2000853310 @default.
• W2801165219 cites W2002941209 @default.
• W2801165219 cites W2005687534 @default.
• W2801165219 cites W2007440356 @default.
• W2801165219 cites W2019465667 @default.
• W2801165219 cites W2025367187 @default.
• W2801165219 cites W2028695639 @default.
• W2801165219 cites W2041235683 @default.
• W2801165219 cites W2045221992 @default.
• W2801165219 cites W2046891044 @default.
• W2801165219 cites W2063382772 @default.
• W2801165219 cites W2065111801 @default.
• W2801165219 cites W2070771807 @default.
• W2801165219 cites W2076136219 @default.
• W2801165219 cites W2086591938 @default.
• W2801165219 cites W2088903681 @default.
• W2801165219 cites W2091199534 @default.
• W2801165219 cites W2094025137 @default.
• W2801165219 cites W2097391350 @default.
• W2801165219 cites W2098537353 @default.
• W2801165219 cites W2099779259 @default.
• W2801165219 cites W2101017316 @default.
• W2801165219 cites W2104858491 @default.
• W2801165219 cites W2104894085 @default.
• W2801165219 cites W2104896102 @default.
• W2801165219 cites W2104991132 @default.
• W2801165219 cites W2107104929 @default.
• W2801165219 cites W2108228345 @default.
• W2801165219 cites W2112084254 @default.
• W2801165219 cites W2114015514 @default.
• W2801165219 cites W2124000742 @default.
• W2801165219 cites W2130171323 @default.
• W2801165219 cites W2130382251 @default.
• W2801165219 cites W2132791546 @default.
• W2801165219 cites W2139537558 @default.
• W2801165219 cites W2140414565 @default.
• W2801165219 cites W2141275282 @default.
• W2801165219 cites W2142374658 @default.
• W2801165219 cites W2142471162 @default.
• W2801165219 cites W2154362351 @default.
• W2801165219 cites W2158115535 @default.
• W2801165219 cites W2159316975 @default.
• W2801165219 cites W2162156002 @default.
• W2801165219 cites W2164481110 @default.
• W2801165219 cites W2464298398 @default.
• W2801165219 cites W2468515859 @default.
• W2801165219 cites W2536942 @default.
• W2801165219 cites W2544263974 @default.
• W2801165219 cites W2568597368 @default.
• W2801165219 cites W2570051065 @default.
• W2801165219 cites W2580449060 @default.
• W2801165219 cites W2724267629 @default.
• W2801165219 cites W4239234884 @default.
• W2801165219 cites W4247364435 @default.
• W2801165219 cites W4255497935 @default.
• W2801165219 cites W7156520 @default.
• W2801165219 doi "https://doi.org/10.1371/journal.pcbi.1006060" @default.
• W2801165219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5919696" @default.
• W2801165219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29659573" @default.
• W2801165219 hasPublicationYear "2018" @default.
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