Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801166051> ?p ?o ?g. }
- W2801166051 endingPage "2065" @default.
- W2801166051 startingPage "2055" @default.
- W2801166051 abstract "Human genetic studies are rapidly identifying variants that increase risk for neurodevelopmental disorders. However, it remains unclear how specific mutations impact brain function and contribute to neuropsychiatric risk. Chromosome 16p11.2 deletion is one of the most common copy number variations in autism and related neurodevelopmental disorders. Using resting state functional MRI data from the Simons Variation in Individuals Project (VIP) database, we show that 16p11.2 deletion carriers exhibit impaired prefrontal connectivity, resulting in weaker long-range functional coupling with temporal-parietal regions. These functional changes are associated with socio-cognitive impairments. We also document that a mouse with the same genetic deficiency exhibits similarly diminished prefrontal connectivity, together with thalamo-prefrontal miswiring and reduced long-range functional synchronization. These results reveal a mechanistic link between specific genetic risk for neurodevelopmental disorders and long-range functional coupling, and suggest that deletion in 16p11.2 may lead to impaired socio-cognitive function via dysregulation of prefrontal connectivity." @default.
- W2801166051 created "2018-05-17" @default.
- W2801166051 creator A5000640278 @default.
- W2801166051 creator A5003911356 @default.
- W2801166051 creator A5010073473 @default.
- W2801166051 creator A5022228180 @default.
- W2801166051 creator A5026729858 @default.
- W2801166051 creator A5033413179 @default.
- W2801166051 creator A5036471912 @default.
- W2801166051 creator A5039093014 @default.
- W2801166051 creator A5049464639 @default.
- W2801166051 creator A5053324548 @default.
- W2801166051 creator A5054445744 @default.
- W2801166051 creator A5069256954 @default.
- W2801166051 creator A5071932050 @default.
- W2801166051 creator A5072821940 @default.
- W2801166051 creator A5082618877 @default.
- W2801166051 creator A5084445936 @default.
- W2801166051 date "2018-05-02" @default.
- W2801166051 modified "2023-10-14" @default.
- W2801166051 title "Autism-associated 16p11.2 microdeletion impairs prefrontal functional connectivity in mouse and human" @default.
- W2801166051 cites W1496570496 @default.
- W2801166051 cites W1522016182 @default.
- W2801166051 cites W1904307646 @default.
- W2801166051 cites W1973234723 @default.
- W2801166051 cites W1975606212 @default.
- W2801166051 cites W1976114527 @default.
- W2801166051 cites W1976555450 @default.
- W2801166051 cites W1981693548 @default.
- W2801166051 cites W1987323424 @default.
- W2801166051 cites W1990134753 @default.
- W2801166051 cites W1996471207 @default.
- W2801166051 cites W1997950587 @default.
- W2801166051 cites W2001784412 @default.
- W2801166051 cites W2020055733 @default.
- W2801166051 cites W2020926765 @default.
- W2801166051 cites W2023621960 @default.
- W2801166051 cites W2026128880 @default.
- W2801166051 cites W2026823182 @default.
- W2801166051 cites W2033865693 @default.
- W2801166051 cites W2035462451 @default.
- W2801166051 cites W2036788448 @default.
- W2801166051 cites W2038427447 @default.
- W2801166051 cites W2049115342 @default.
- W2801166051 cites W2052578932 @default.
- W2801166051 cites W2053379500 @default.
- W2801166051 cites W2060982963 @default.
- W2801166051 cites W2063404606 @default.
- W2801166051 cites W2065418093 @default.
- W2801166051 cites W2068252829 @default.
- W2801166051 cites W2070632454 @default.
- W2801166051 cites W2082352870 @default.
- W2801166051 cites W2087129491 @default.
- W2801166051 cites W2089244139 @default.
- W2801166051 cites W2089698459 @default.
- W2801166051 cites W2099440139 @default.
- W2801166051 cites W2101436791 @default.
- W2801166051 cites W2104482304 @default.
- W2801166051 cites W2109214922 @default.
- W2801166051 cites W2111234698 @default.
- W2801166051 cites W2116476161 @default.
- W2801166051 cites W2117381227 @default.
- W2801166051 cites W2118636975 @default.
- W2801166051 cites W2120911948 @default.
- W2801166051 cites W2127753140 @default.
- W2801166051 cites W2139097417 @default.
- W2801166051 cites W2140142910 @default.
- W2801166051 cites W2142680666 @default.
- W2801166051 cites W2146717423 @default.
- W2801166051 cites W2149561999 @default.
- W2801166051 cites W2160629976 @default.
- W2801166051 cites W2162066558 @default.
- W2801166051 cites W2167868121 @default.
- W2801166051 cites W2207583083 @default.
- W2801166051 cites W2217108923 @default.
- W2801166051 cites W2288200835 @default.
- W2801166051 cites W2299886504 @default.
- W2801166051 cites W2316811866 @default.
- W2801166051 cites W2407083337 @default.
- W2801166051 cites W2514605726 @default.
- W2801166051 cites W2557089988 @default.
- W2801166051 cites W2568162413 @default.
- W2801166051 cites W2587492999 @default.
- W2801166051 cites W2604707717 @default.
- W2801166051 cites W2738593148 @default.
- W2801166051 cites W2742420769 @default.
- W2801166051 cites W2765507708 @default.
- W2801166051 cites W2951798480 @default.
- W2801166051 cites W2953112424 @default.
- W2801166051 doi "https://doi.org/10.1093/brain/awy111" @default.
- W2801166051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29722793" @default.
- W2801166051 hasPublicationYear "2018" @default.
- W2801166051 type Work @default.
- W2801166051 sameAs 2801166051 @default.
- W2801166051 citedByCount "90" @default.
- W2801166051 countsByYear W28011660512018 @default.
- W2801166051 countsByYear W28011660512019 @default.
- W2801166051 countsByYear W28011660512020 @default.