Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801171837> ?p ?o ?g. }
- W2801171837 abstract "Caponization results in reduced androgen levels, which leads to abdominal fat accumulation in capons. In this study, we sought to understand the molecular mechanisms behind this fat accumulation.Abdominal fat (AF) content increased significantly (P < 0.05) and serum and AF testosterone levels decreased significantly (P < 0.05 or P < 0.01) after caponization. In AF tissue, 90 differentially expressed genes related to lipid metabolism were screened by gene expression profiling in caponized and sham-treated chickens. Among these, six representative genes were significantly up-regulated (APOA1, SCD, FABP7, RXRG, and FADS2) or down-regulated (FABP3) (P < 0.05 or P < 0.01) and were strongly associated with the PPAR pathway. In addition, cell junction pathways were also enriched. In vitro, Fat content was significantly lower in cells treated with testosterone compared with control cells (P < 0.01), and mRNA levels of RXRG, FABP7, and FABP3 changed accordingly, confirming the effect of testosterone on fat deposition.The results of this study indicate that testosterone reduction likely regulates gene expression through PPAR and cell junction pathways resulting in increased fat accumulation. These results provide increase our understanding of the biological mechanisms by which caponization induces greater fat accumulation." @default.
- W2801171837 created "2018-05-17" @default.
- W2801171837 creator A5006016361 @default.
- W2801171837 creator A5028264942 @default.
- W2801171837 creator A5035526338 @default.
- W2801171837 creator A5045582315 @default.
- W2801171837 creator A5049264813 @default.
- W2801171837 creator A5077660186 @default.
- W2801171837 creator A5078433811 @default.
- W2801171837 creator A5090600999 @default.
- W2801171837 date "2018-05-09" @default.
- W2801171837 modified "2023-10-17" @default.
- W2801171837 title "Decreased testosterone levels after caponization leads to abdominal fat deposition in chickens" @default.
- W2801171837 cites W1596515083 @default.
- W2801171837 cites W1971355109 @default.
- W2801171837 cites W1977176637 @default.
- W2801171837 cites W1997613626 @default.
- W2801171837 cites W2004316716 @default.
- W2801171837 cites W2010023375 @default.
- W2801171837 cites W2036805462 @default.
- W2801171837 cites W2050250213 @default.
- W2801171837 cites W2053641994 @default.
- W2801171837 cites W2057015734 @default.
- W2801171837 cites W2064506156 @default.
- W2801171837 cites W2064549818 @default.
- W2801171837 cites W2069045161 @default.
- W2801171837 cites W2071765579 @default.
- W2801171837 cites W2092004604 @default.
- W2801171837 cites W2105106534 @default.
- W2801171837 cites W2107277218 @default.
- W2801171837 cites W2108833696 @default.
- W2801171837 cites W2120716797 @default.
- W2801171837 cites W2124693613 @default.
- W2801171837 cites W2129374269 @default.
- W2801171837 cites W2132485471 @default.
- W2801171837 cites W2144279110 @default.
- W2801171837 cites W2154431984 @default.
- W2801171837 cites W2159851610 @default.
- W2801171837 cites W2160861436 @default.
- W2801171837 cites W2163254595 @default.
- W2801171837 cites W2165956529 @default.
- W2801171837 cites W2168118743 @default.
- W2801171837 cites W2192080449 @default.
- W2801171837 cites W222885952 @default.
- W2801171837 cites W2237756094 @default.
- W2801171837 cites W2302949250 @default.
- W2801171837 cites W2309557723 @default.
- W2801171837 cites W2328410914 @default.
- W2801171837 cites W2530447517 @default.
- W2801171837 cites W2548669216 @default.
- W2801171837 cites W2624929695 @default.
- W2801171837 cites W2735720940 @default.
- W2801171837 doi "https://doi.org/10.1186/s12864-018-4737-3" @default.
- W2801171837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5944178" @default.
- W2801171837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29743036" @default.
- W2801171837 hasPublicationYear "2018" @default.
- W2801171837 type Work @default.
- W2801171837 sameAs 2801171837 @default.
- W2801171837 citedByCount "18" @default.
- W2801171837 countsByYear W28011718372018 @default.
- W2801171837 countsByYear W28011718372019 @default.
- W2801171837 countsByYear W28011718372021 @default.
- W2801171837 countsByYear W28011718372022 @default.
- W2801171837 countsByYear W28011718372023 @default.
- W2801171837 crossrefType "journal-article" @default.
- W2801171837 hasAuthorship W2801171837A5006016361 @default.
- W2801171837 hasAuthorship W2801171837A5028264942 @default.
- W2801171837 hasAuthorship W2801171837A5035526338 @default.
- W2801171837 hasAuthorship W2801171837A5045582315 @default.
- W2801171837 hasAuthorship W2801171837A5049264813 @default.
- W2801171837 hasAuthorship W2801171837A5077660186 @default.
- W2801171837 hasAuthorship W2801171837A5078433811 @default.
- W2801171837 hasAuthorship W2801171837A5090600999 @default.
- W2801171837 hasBestOaLocation W28011718371 @default.
- W2801171837 hasConcept C104317684 @default.
- W2801171837 hasConcept C126322002 @default.
- W2801171837 hasConcept C134018914 @default.
- W2801171837 hasConcept C150194340 @default.
- W2801171837 hasConcept C171089720 @default.
- W2801171837 hasConcept C2777911890 @default.
- W2801171837 hasConcept C2779279991 @default.
- W2801171837 hasConcept C4733338 @default.
- W2801171837 hasConcept C55493867 @default.
- W2801171837 hasConcept C71315377 @default.
- W2801171837 hasConcept C71924100 @default.
- W2801171837 hasConcept C86803240 @default.
- W2801171837 hasConceptScore W2801171837C104317684 @default.
- W2801171837 hasConceptScore W2801171837C126322002 @default.
- W2801171837 hasConceptScore W2801171837C134018914 @default.
- W2801171837 hasConceptScore W2801171837C150194340 @default.
- W2801171837 hasConceptScore W2801171837C171089720 @default.
- W2801171837 hasConceptScore W2801171837C2777911890 @default.
- W2801171837 hasConceptScore W2801171837C2779279991 @default.
- W2801171837 hasConceptScore W2801171837C4733338 @default.
- W2801171837 hasConceptScore W2801171837C55493867 @default.
- W2801171837 hasConceptScore W2801171837C71315377 @default.
- W2801171837 hasConceptScore W2801171837C71924100 @default.
- W2801171837 hasConceptScore W2801171837C86803240 @default.
- W2801171837 hasFunder F4320335848 @default.
- W2801171837 hasIssue "1" @default.