Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801171849> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2801171849 endingPage "S210" @default.
- W2801171849 startingPage "S210" @default.
- W2801171849 abstract "The activation of the RAS-RAF-MEK-ERK signal pathway has been associated with tumor progression. A selective BRAF protein kinase inhibitor, vemurafenib, exhibits anti-tumorigenic activity in patients with metastatic melanoma. Many patients treated with vemurafenib develop common cutaneous disorders including dry skin and acne-like rashes, which are closely associated with the dysfunction of sebaceous glands and pilosebaceous units. However, there have been no reports to date that vemurafenib may modulate sebum production in sebaceous glands. In the present study, we examined whether or not vemurafenib directly influenced sebum production in hamster sebocytes (HamSEB) in vitro. Insulin-augmented intracellular lipid-droplet formation was enhanced by vemurafenib in HamSEB, which was due to the increased production of triacylglycerols (TG), a major component of sebum. On the other hand, vemurafenib was found to suppress 5α-dihydrotestosterone (5α-DHT)-induced lipid-droplet formation and TG production in HamSEB. Thus, vemurafenib is likely to enhance or suppress sebum production, depending on lipogenetic factor species in sebaceous glands. These findings may increase the clinical understanding of the side effects of vemurafenib." @default.
- W2801171849 created "2018-05-17" @default.
- W2801171849 creator A5011942681 @default.
- W2801171849 creator A5062065810 @default.
- W2801171849 creator A5070825498 @default.
- W2801171849 date "2018-05-01" @default.
- W2801171849 modified "2023-10-14" @default.
- W2801171849 title "1238 A BRAF inhibitor, vemurafenib, enhances insulin-induced sebum production but antagonizes 5α-DHT-mediated sebaceous lipogenesis in hamster sebocytes" @default.
- W2801171849 doi "https://doi.org/10.1016/j.jid.2018.03.1253" @default.
- W2801171849 hasPublicationYear "2018" @default.
- W2801171849 type Work @default.
- W2801171849 sameAs 2801171849 @default.
- W2801171849 citedByCount "0" @default.
- W2801171849 crossrefType "journal-article" @default.
- W2801171849 hasAuthorship W2801171849A5011942681 @default.
- W2801171849 hasAuthorship W2801171849A5062065810 @default.
- W2801171849 hasAuthorship W2801171849A5070825498 @default.
- W2801171849 hasBestOaLocation W28011718491 @default.
- W2801171849 hasConcept C126322002 @default.
- W2801171849 hasConcept C134018914 @default.
- W2801171849 hasConcept C141359234 @default.
- W2801171849 hasConcept C184235292 @default.
- W2801171849 hasConcept C185592680 @default.
- W2801171849 hasConcept C2776131300 @default.
- W2801171849 hasConcept C2777363609 @default.
- W2801171849 hasConcept C2777658100 @default.
- W2801171849 hasConcept C2777911890 @default.
- W2801171849 hasConcept C2778575167 @default.
- W2801171849 hasConcept C2779881493 @default.
- W2801171849 hasConcept C2994587330 @default.
- W2801171849 hasConcept C4733338 @default.
- W2801171849 hasConcept C502942594 @default.
- W2801171849 hasConcept C55493867 @default.
- W2801171849 hasConcept C57074206 @default.
- W2801171849 hasConcept C71315377 @default.
- W2801171849 hasConcept C71924100 @default.
- W2801171849 hasConceptScore W2801171849C126322002 @default.
- W2801171849 hasConceptScore W2801171849C134018914 @default.
- W2801171849 hasConceptScore W2801171849C141359234 @default.
- W2801171849 hasConceptScore W2801171849C184235292 @default.
- W2801171849 hasConceptScore W2801171849C185592680 @default.
- W2801171849 hasConceptScore W2801171849C2776131300 @default.
- W2801171849 hasConceptScore W2801171849C2777363609 @default.
- W2801171849 hasConceptScore W2801171849C2777658100 @default.
- W2801171849 hasConceptScore W2801171849C2777911890 @default.
- W2801171849 hasConceptScore W2801171849C2778575167 @default.
- W2801171849 hasConceptScore W2801171849C2779881493 @default.
- W2801171849 hasConceptScore W2801171849C2994587330 @default.
- W2801171849 hasConceptScore W2801171849C4733338 @default.
- W2801171849 hasConceptScore W2801171849C502942594 @default.
- W2801171849 hasConceptScore W2801171849C55493867 @default.
- W2801171849 hasConceptScore W2801171849C57074206 @default.
- W2801171849 hasConceptScore W2801171849C71315377 @default.
- W2801171849 hasConceptScore W2801171849C71924100 @default.
- W2801171849 hasIssue "5" @default.
- W2801171849 hasLocation W28011718491 @default.
- W2801171849 hasOpenAccess W2801171849 @default.
- W2801171849 hasPrimaryLocation W28011718491 @default.
- W2801171849 hasRelatedWork W2000876153 @default.
- W2801171849 hasRelatedWork W2050194585 @default.
- W2801171849 hasRelatedWork W2063133456 @default.
- W2801171849 hasRelatedWork W2164992866 @default.
- W2801171849 hasRelatedWork W2328771497 @default.
- W2801171849 hasRelatedWork W2331291943 @default.
- W2801171849 hasRelatedWork W2767735945 @default.
- W2801171849 hasRelatedWork W3034913290 @default.
- W2801171849 hasRelatedWork W3045209127 @default.
- W2801171849 hasRelatedWork W4283643259 @default.
- W2801171849 hasVolume "138" @default.
- W2801171849 isParatext "false" @default.
- W2801171849 isRetracted "false" @default.
- W2801171849 magId "2801171849" @default.
- W2801171849 workType "article" @default.