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• W2801172275 endingPage "6774" @default.
• W2801172275 startingPage "6765" @default.
• W2801172275 abstract "Abstract One important feature of cerebral ischemia is hypoxia injury in nerve cells. Growth arrest‐specific transcript 5 (GAS5) is widely reported as a tumor suppressor gene; however, the investigations about its role in cerebrovascular disease are relatively rare. This study was aimed to explore the impact of GAS5 on hypoxia response in nervous cells. PC‐12 cells were incubated under anoxic condition to induce hypoxia injury. Regulatory effects of GAS5 on miR‐124 and miR‐124 on ICAM‐1 expression were assessed by qRT‐PCR and/or Western blot. Targeting effect of miR‐124 on ICAM‐1 3′‐untranslated regions (UTR) was evaluated through dual luciferase activity assay. The potential regulatory mechanism on hypoxia injury in PC‐12 cells was assessed by detecting key elements of NF‐κB and Notch signaling pathways using Western blot. GAS5 ectopic expression accentuated hypoxia injury in PC‐12 cells. miR‐124 expression was negatively regulated by GAS5 expression. Cells with overexpressions of GAS5 and miR‐124 alleviated hypoxia injury as in compassion with cells only with GAS5 overexpression. ICAM‐1 expression was negatively regulated by miR‐124 expression. ICAM‐1 was a functional target of miR‐124. ICAM‐1 overexpression aggravated hypoxia injury, but inversely, ICAM‐1 silence diminished hypoxia damage. Besides, ICAM‐1 expression was negatively related with activation of NF‐κB and Notch pathways. GAS5‐miR‐124‐ICAM‐1 axis could regulate hypoxia injury in PC‐12 cells. GAS5 might aggravate hypoxia injury via down‐regulating miR‐124, then up‐regulating ICAM‐1, and further enhancing activations of NF‐κB and Notch pathways." @default.
• W2801172275 created "2018-05-17" @default.
• W2801172275 creator A5020310967 @default.
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• W2801172275 date "2018-05-08" @default.
• W2801172275 modified "2023-09-25" @default.
• W2801172275 title "<i>Retracted</i>: Long non‐coding RNA GAS5 aggravates hypoxia injury in PC‐12 cells via down‐regulating miR‐124" @default.
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• W2801172275 doi "https://doi.org/10.1002/jcb.26870" @default.
• W2801172275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29737538" @default.
• W2801172275 hasPublicationYear "2018" @default.
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