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• W2801177830 abstract "// Daniel F. Lusche 1 , Emma C. Buchele 1 , Kanoe B. Russell 1 , Benjamin A. Soll 1 , Michele I. Vitolo 2 , Michael R. Klemme 1 , Deborah J. Wessels 1 and David R. Soll 1 1 Developmental Studies Hybridoma Bank and W.M. Keck Dynamic Image Analysis Facility, Department of Biology, The University of Iowa, Iowa City, 52242 IA, USA 2 Greenebaum Cancer Center, The University of Maryland, Baltimore, Maryland, Baltimore, 21201 MD, USA Correspondence to: David R. Soll, email: david-soll@uiowa.edu Keywords: cancer cell rescue; tumor suppressor; transmembrane phosphatase; TPTE2 TPIP; wound healing Received: November 16, 2017      Accepted: March 06, 2018      Published: April 20, 2018 ABSTRACT One possible approach to normalize mutant cells that are metastatic and tumorigenic, is to upregulate a functionally similar homolog of the mutated gene. Here we have explored this hypothesis by generating an overexpressor of TPTE2 ( TPIP ), a homolog of PTEN , in PTEN –/– mutants, the latter generated by targeted mutagenesis of a human epithelial cell line. Overexpression of TPTE2 normalized phenotypic changes associated with the PTEN mutation. The PTEN –/– -associated changes rescued by overexpressing TPTE2 included 1) accelerated wound healing in the presence or absence of added growth factors (GFs), 2) increased division rates on a 2D substrate in the presence of GFs, 3) adhesion and viability on a 2D substrate in the absence of GFs, 4) viability in a 3D Matrigel model in the absence of GFs and substrate adhesion 5) loss of apoptosis-associated annexin V cell surface binding sites. The results justify further exploration into the possibility that upregulating TPTE2 by a drug may reverse metastatic and tumorigenic phenotypes mediated in part by a mutation in PTEN . This strategy may also be applicable to other tumorigenic mutations in which a homolog to the mutated gene is present and can substitute functionally." @default.
• W2801177830 created "2018-05-17" @default.
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• W2801177830 creator A5079572031 @default.
• W2801177830 date "2018-04-20" @default.
• W2801177830 modified "2023-09-26" @default.
• W2801177830 title "Overexpressing<i>TPTE2</i>(<i>TPIP</i>), a homolog of the human tumor suppressor gene<i>PTEN</i>, rescues the abnormal phenotype of the<i>PTEN−/−</i>mutant" @default.
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