FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801184429> ?p ?o ?g. }

• W2801184429 endingPage "1326" @default.
• W2801184429 startingPage "1315" @default.
• W2801184429 abstract "Proton pump inhibitors (PPIs) are commonly used as a supplement to cancer therapy. Yet, their effect on cancer mortality is largely unknown. Using data from Danish nationwide registries and Cox models regressing of both propensity scores and drug use, we estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for cancer‐specific and noncancer death among PPI users (≥2 prescriptions within six months after diagnosis; n = 36,066) compared with nonusers (<2 prescriptions, n = 311,853) or users of histamine H 2 ‐receptor antagonists (H 2 RA; n = 5,152). Adjusted HRs for cancer‐specific mortality among postdiagnostic PPI users as compared with nonusers or H 2 RA users were 1.29 (95% CI, 1.27–1.32) and 1.15 (95% CI, 1.10–1.20), respectively. HRs for cancer mortality associated with PPI use were highest for ovarian (1.35; 95% CI, 1.20–1.52) and lowest for esophageal cancer (0.91; 95% CI, 0.81–1.04). The associations were stronger among new PPI users after cancer diagnosis, indicating potential confounding. To test the effect of PPIs on tumor growth in a model system free for confounding factors, we investigated the effect of pantoprazole on tumor growth in mice. Pantoprazole (5 mg/kg/day) enhanced tumor growth ( p = 0.033) and reduced the antitumor activity of gemcitabine ( p = 0.008) in fibrosarcoma‐bearing Balb/c mice, but not in immunodeficient Balb/c nude mice. In breast carcinoma‐bearing FVB/N mice, pantoprazole had no effect on tumor growth alone but it reduced the life‐prolonging effect of doxorubicin significantly ( p = 0.007). Taken together, these data raise concerns about the increasing use of PPIs and calls for further studies addressing their safety among cancer patients." @default.
• W2801184429 created "2018-05-17" @default.
• W2801184429 creator A5023698795 @default.
• W2801184429 creator A5050957961 @default.
• W2801184429 creator A5057073436 @default.
• W2801184429 creator A5076112400 @default.
• W2801184429 creator A5086726027 @default.
• W2801184429 date "2018-05-02" @default.
• W2801184429 modified "2023-10-15" @default.
• W2801184429 title "Proton pump inhibitor use and cancer mortality" @default.
• W2801184429 cites W1974140746 @default.
• W2801184429 cites W1981759904 @default.
• W2801184429 cites W1984850666 @default.
• W2801184429 cites W1987074547 @default.
• W2801184429 cites W1996088849 @default.
• W2801184429 cites W2000445173 @default.
• W2801184429 cites W2007482851 @default.
• W2801184429 cites W2011100333 @default.
• W2801184429 cites W2012899520 @default.
• W2801184429 cites W2037907802 @default.
• W2801184429 cites W2041469841 @default.
• W2801184429 cites W2060642429 @default.
• W2801184429 cites W2064517127 @default.
• W2801184429 cites W2072157098 @default.
• W2801184429 cites W2074546881 @default.
• W2801184429 cites W2079480002 @default.
• W2801184429 cites W2080402063 @default.
• W2801184429 cites W2102420102 @default.
• W2801184429 cites W2104824311 @default.
• W2801184429 cites W2109690807 @default.
• W2801184429 cites W2142153200 @default.
• W2801184429 cites W2145994992 @default.
• W2801184429 cites W2146037312 @default.
• W2801184429 cites W2146226748 @default.
• W2801184429 cites W2147108549 @default.
• W2801184429 cites W2151278054 @default.
• W2801184429 cites W2160208506 @default.
• W2801184429 cites W2171444389 @default.
• W2801184429 cites W2176850049 @default.
• W2801184429 cites W2219591537 @default.
• W2801184429 cites W2252719556 @default.
• W2801184429 cites W2281035315 @default.
• W2801184429 cites W2528292047 @default.
• W2801184429 cites W2603518487 @default.
• W2801184429 doi "https://doi.org/10.1002/ijc.31529" @default.
• W2801184429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7611279" @default.
• W2801184429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29658114" @default.
• W2801184429 hasPublicationYear "2018" @default.
• W2801184429 type Work @default.
• W2801184429 sameAs 2801184429 @default.
• W2801184429 citedByCount "36" @default.
• W2801184429 countsByYear W28011844292018 @default.
• W2801184429 countsByYear W28011844292019 @default.
• W2801184429 countsByYear W28011844292020 @default.
• W2801184429 countsByYear W28011844292021 @default.
• W2801184429 countsByYear W28011844292022 @default.
• W2801184429 countsByYear W28011844292023 @default.
• W2801184429 crossrefType "journal-article" @default.
• W2801184429 hasAuthorship W2801184429A5023698795 @default.
• W2801184429 hasAuthorship W2801184429A5050957961 @default.
• W2801184429 hasAuthorship W2801184429A5057073436 @default.
• W2801184429 hasAuthorship W2801184429A5076112400 @default.
• W2801184429 hasAuthorship W2801184429A5086726027 @default.
• W2801184429 hasBestOaLocation W28011844291 @default.
• W2801184429 hasConcept C121608353 @default.
• W2801184429 hasConcept C126322002 @default.
• W2801184429 hasConcept C143998085 @default.
• W2801184429 hasConcept C207103383 @default.
• W2801184429 hasConcept C2777498785 @default.
• W2801184429 hasConcept C2780258809 @default.
• W2801184429 hasConcept C2781315423 @default.
• W2801184429 hasConcept C44249647 @default.
• W2801184429 hasConcept C50382708 @default.
• W2801184429 hasConcept C71924100 @default.
• W2801184429 hasConcept C77350462 @default.
• W2801184429 hasConcept C90924648 @default.
• W2801184429 hasConceptScore W2801184429C121608353 @default.
• W2801184429 hasConceptScore W2801184429C126322002 @default.
• W2801184429 hasConceptScore W2801184429C143998085 @default.
• W2801184429 hasConceptScore W2801184429C207103383 @default.
• W2801184429 hasConceptScore W2801184429C2777498785 @default.
• W2801184429 hasConceptScore W2801184429C2780258809 @default.
• W2801184429 hasConceptScore W2801184429C2781315423 @default.
• W2801184429 hasConceptScore W2801184429C44249647 @default.
• W2801184429 hasConceptScore W2801184429C50382708 @default.
• W2801184429 hasConceptScore W2801184429C71924100 @default.
• W2801184429 hasConceptScore W2801184429C77350462 @default.
• W2801184429 hasConceptScore W2801184429C90924648 @default.
• W2801184429 hasFunder F4320310455 @default.
• W2801184429 hasFunder F4320320038 @default.
• W2801184429 hasFunder F4320320943 @default.
• W2801184429 hasFunder F4320338335 @default.
• W2801184429 hasIssue "6" @default.
• W2801184429 hasLocation W28011844291 @default.
• W2801184429 hasLocation W28011844292 @default.
• W2801184429 hasOpenAccess W2801184429 @default.
• W2801184429 hasPrimaryLocation W28011844291 @default.
• W2801184429 hasRelatedWork W135063651 @default.

• next