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- W2801185119 abstract "The sequence of a large number of MHC-presented epitopes is not present as such in the original antigen because it has been re-shuffled by the proteasome or other proteases. Why do proteases throw a spanner in the works of our model of antigen tagging and immune recognition? We describe in this review what we know about the immunological relevance of post-translationally spliced epitopes and why proteases seem to have a second (dark) personality, which is keen to create new peptide bonds." @default.
- W2801185119 created "2018-05-17" @default.
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- W2801185119 date "2018-06-01" @default.
- W2801185119 modified "2023-10-16" @default.
- W2801185119 title "Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?" @default.
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- W2801185119 doi "https://doi.org/10.1016/j.coi.2018.04.016" @default.
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