FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801196557> ?p ?o ?g. }

• W2801196557 abstract "The interaction between cancer cells and stromal components contributes to cancer invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC). The present study investigated the role of the correlation between annexin II (ANX2) and stromal tenascin C (TNC) with the progression of PDAC. The functions of the expression ANX2 and TNC were assessed in in vitro experiments using mouse and human PDAC cells, and the clinical effect was analyzed using immunohistochemistry with surgically resected PDAC tissues. The effects on epithelial to mesenchymal transition (EMT), invasion, putative cancer stemness, and anoikis resistance were examined in vitro using murine precancerous pancreatic intraepithelial neoplasia (PanIN) cells and murine and human invasive PDAC cells with ANX2 knockdown using specific small interfering RNA (siRNA)s and recombinant TNC (rTNC). ANX2 was expressed at a high level in primary PanIN cells and invasive PDAC cells, compared with the levels in liver metastatic PDAC cells. In the ANX2‑knockdown cells, there were fewer cells with a morphological mesenchymal appearance in three‑dimensional culture and invasion was reduced compared with that in the control cells. Morphological change into the mesenchymal phenotype and invasion were enhanced by rTNC treatment in the control PDAC cells but not in the ANX2‑knockdown cells. Pancreatosphere formation assays showed that ANX2 and TNC facilitated the maintenance of stem‑like characters in PDAC cells. Furthermore, anoikis assays indicated that the interaction of ANX2‑TNC contributed to anoikis resistance in PDAC cells. In the immunohistochemistry analyses, the group with a high expression of ANX2 and high stromal TNC was significantly correlated with distant metastasis, and was associated with hematogenous/peritoneal recurrence and poor outcomes following surgery in resected human primary PDAC tissues. In conclusion, the results demonstrated that ANX2 and stromal TNC regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of PDAC. These results indicate the potential of the ANX2‑TNC axis as a therapeutic target for PDAC metastasis." @default.
• W2801196557 created "2018-05-17" @default.
• W2801196557 creator A5019210760 @default.
• W2801196557 creator A5020490910 @default.
• W2801196557 creator A5031074152 @default.
• W2801196557 creator A5032236530 @default.
• W2801196557 creator A5035413225 @default.
• W2801196557 creator A5041213463 @default.
• W2801196557 creator A5043459798 @default.
• W2801196557 creator A5051169610 @default.
• W2801196557 creator A5072527554 @default.
• W2801196557 creator A5080766585 @default.
• W2801196557 creator A5088359032 @default.
• W2801196557 date "2018-05-02" @default.
• W2801196557 modified "2023-09-23" @default.
• W2801196557 title "Expression of annexin�II and stromal tenascin�C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer" @default.
• W2801196557 cites W1592768381 @default.
• W2801196557 cites W1868626511 @default.
• W2801196557 cites W1946441967 @default.
• W2801196557 cites W1968812902 @default.
• W2801196557 cites W1992995822 @default.
• W2801196557 cites W2014691022 @default.
• W2801196557 cites W2022366555 @default.
• W2801196557 cites W2024681421 @default.
• W2801196557 cites W2046445536 @default.
• W2801196557 cites W2070595880 @default.
• W2801196557 cites W2074241794 @default.
• W2801196557 cites W2080232352 @default.
• W2801196557 cites W2082345666 @default.
• W2801196557 cites W2093921289 @default.
• W2801196557 cites W2096180495 @default.
• W2801196557 cites W2101619182 @default.
• W2801196557 cites W2106572080 @default.
• W2801196557 cites W2114217733 @default.
• W2801196557 cites W2119578188 @default.
• W2801196557 cites W2128042529 @default.
• W2801196557 cites W2150322923 @default.
• W2801196557 cites W2157923000 @default.
• W2801196557 cites W2171190291 @default.
• W2801196557 cites W2177984400 @default.
• W2801196557 cites W2247842506 @default.
• W2801196557 cites W2292593918 @default.
• W2801196557 cites W2570618306 @default.
• W2801196557 cites W2741928029 @default.
• W2801196557 cites W2744135888 @default.
• W2801196557 cites W4229719081 @default.
• W2801196557 doi "https://doi.org/10.3892/ijmm.2018.3652" @default.
• W2801196557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6034933" @default.
• W2801196557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29749431" @default.
• W2801196557 hasPublicationYear "2018" @default.
• W2801196557 type Work @default.
• W2801196557 sameAs 2801196557 @default.
• W2801196557 citedByCount "15" @default.
• W2801196557 countsByYear W28011965572019 @default.
• W2801196557 countsByYear W28011965572020 @default.
• W2801196557 countsByYear W28011965572021 @default.
• W2801196557 countsByYear W28011965572022 @default.
• W2801196557 countsByYear W28011965572023 @default.
• W2801196557 crossrefType "journal-article" @default.
• W2801196557 hasAuthorship W2801196557A5019210760 @default.
• W2801196557 hasAuthorship W2801196557A5020490910 @default.
• W2801196557 hasAuthorship W2801196557A5031074152 @default.
• W2801196557 hasAuthorship W2801196557A5032236530 @default.
• W2801196557 hasAuthorship W2801196557A5035413225 @default.
• W2801196557 hasAuthorship W2801196557A5041213463 @default.
• W2801196557 hasAuthorship W2801196557A5043459798 @default.
• W2801196557 hasAuthorship W2801196557A5051169610 @default.
• W2801196557 hasAuthorship W2801196557A5072527554 @default.
• W2801196557 hasAuthorship W2801196557A5080766585 @default.
• W2801196557 hasAuthorship W2801196557A5088359032 @default.
• W2801196557 hasBestOaLocation W28011965571 @default.
• W2801196557 hasConcept C121608353 @default.
• W2801196557 hasConcept C142724271 @default.
• W2801196557 hasConcept C152000582 @default.
• W2801196557 hasConcept C16930146 @default.
• W2801196557 hasConcept C173396325 @default.
• W2801196557 hasConcept C198826908 @default.
• W2801196557 hasConcept C2779013556 @default.
• W2801196557 hasConcept C2780210213 @default.
• W2801196557 hasConcept C28328180 @default.
• W2801196557 hasConcept C502942594 @default.
• W2801196557 hasConcept C54355233 @default.
• W2801196557 hasConcept C55427017 @default.
• W2801196557 hasConcept C71924100 @default.
• W2801196557 hasConcept C76419328 @default.
• W2801196557 hasConcept C81885089 @default.
• W2801196557 hasConcept C86803240 @default.
• W2801196557 hasConcept C95444343 @default.
• W2801196557 hasConcept C96232424 @default.
• W2801196557 hasConceptScore W2801196557C121608353 @default.
• W2801196557 hasConceptScore W2801196557C142724271 @default.
• W2801196557 hasConceptScore W2801196557C152000582 @default.
• W2801196557 hasConceptScore W2801196557C16930146 @default.
• W2801196557 hasConceptScore W2801196557C173396325 @default.
• W2801196557 hasConceptScore W2801196557C198826908 @default.
• W2801196557 hasConceptScore W2801196557C2779013556 @default.
• W2801196557 hasConceptScore W2801196557C2780210213 @default.
• W2801196557 hasConceptScore W2801196557C28328180 @default.
• W2801196557 hasConceptScore W2801196557C502942594 @default.
• W2801196557 hasConceptScore W2801196557C54355233 @default.

• next