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- W2801205485 abstract "The ubiquitin proteasome system (UPS) regulated human biological processes through the appropriate and efficient proteolysis of cellular proteins. F‑box proteins are the vital components of SKP1‑CUL1‑FBP (SCF)‑type E3 ubiquitin ligases that determine substrate specificity. As F‑box proteins have the ability to control the degradation of several crucial protein targets associated with drug resistance, the dysregulation of these proteins may lead to induction of chemoresistance in cancer cells. Chemotherapy is one of the most conventional therapeutic approaches of treatment of patients with cancer. However, its exclusive application in clinical settings is restricted due to the development of chemoresistance, which typically results treatment failure. Therefore, overcoming drug resistance is considered as one of the most critical issues that researchers and clinician associated with oncology face. The present review serves to provide a comprehensive overview of F‑box proteins and their possible targets as well as their correlation with the chemoresistance and chemosensitization of cancer cells. The article also presents an integrated representation of the complex regulatory mechanisms responsible for chemoresistance, which may lay the foundation to explore sensible candidate drugs for therapeutic intervention." @default.
- W2801205485 created "2018-05-17" @default.
- W2801205485 creator A5011236043 @default.
- W2801205485 creator A5014982480 @default.
- W2801205485 creator A5015531883 @default.
- W2801205485 creator A5039532295 @default.
- W2801205485 date "2018-04-16" @default.
- W2801205485 modified "2023-09-24" @default.
- W2801205485 title "F‑box proteins involved in cancer‑associated drug resistance (Review)" @default.
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