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• W2801214183 abstract "Abstract Coronary artery disease (CAD) is the single leading cause of death worldwide. Advances in treatment and management have significantly improved patient outcomes. On the other hand, although mortality rates have decreased, more people are left with sequelae that require additional treatment and hospitalization. Moreover, patients with severe nonrevascularizable CAD remain with only the option of heart transplantation, which is limited by the shortage of suitable donors. In recent years, cell-based regenerative therapy has emerged as a possible alternative treatment, with several regenerative medicinal products already in the clinical phase of development and others emerging as competitive preclinical solutions. Recent evidence indicates that pericytes, the mural cells of blood microvessels, represent a promising therapeutic candidate. Pericytes are abundant in the human body, play an active role in angiogenesis, vessel stabilization and blood flow regulation, and possess the capacity to differentiate into multiple cells of the mesenchymal lineage. Moreover, early studies suggest a robustness to hypoxic insult, making them uniquely equipped to withstand the ischemic microenvironment. This review summarizes the rationale behind pericyte-based cell therapy and the progress that has been made toward its clinical application. We present the different sources of pericytes and the case for harvesting them from tissue leftovers of cardiovascular surgery. We also discuss the healing potential of pericytes in preclinical animal models of myocardial ischemia (MI) and current practices to upgrade the production protocol for translation to the clinic. Standardization of these procedures is of utmost importance, as lack of uniformity in cell manufacturing may influence clinical outcome." @default.
• W2801214183 created "2018-05-17" @default.
• W2801214183 creator A5011359646 @default.
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• W2801214183 creator A5046839896 @default.
• W2801214183 creator A5051048337 @default.
• W2801214183 date "2018-05-31" @default.
• W2801214183 modified "2023-10-09" @default.
• W2801214183 title "Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation" @default.
• W2801214183 cites W1488565908 @default.
• W2801214183 cites W1514803062 @default.
• W2801214183 cites W1521262132 @default.
• W2801214183 cites W1540025214 @default.
• W2801214183 cites W1559124240 @default.
• W2801214183 cites W1577508883 @default.
• W2801214183 cites W1733152064 @default.
• W2801214183 cites W1761108822 @default.
• W2801214183 cites W1862989971 @default.
• W2801214183 cites W1893055997 @default.
• W2801214183 cites W1950404645 @default.
• W2801214183 cites W1963558489 @default.
• W2801214183 cites W1966786218 @default.
• W2801214183 cites W1967144398 @default.
• W2801214183 cites W1967942542 @default.
• W2801214183 cites W1968071402 @default.
• W2801214183 cites W1968853121 @default.
• W2801214183 cites W1975187390 @default.
• W2801214183 cites W1979096558 @default.
• W2801214183 cites W1979155684 @default.
• W2801214183 cites W1981018261 @default.
• W2801214183 cites W1986121492 @default.
• W2801214183 cites W1990493390 @default.
• W2801214183 cites W1992112921 @default.
• W2801214183 cites W1992190771 @default.
• W2801214183 cites W1994411144 @default.
• W2801214183 cites W1999574305 @default.
• W2801214183 cites W2001552996 @default.
• W2801214183 cites W2001634461 @default.
• W2801214183 cites W2002111397 @default.
• W2801214183 cites W2006431507 @default.
• W2801214183 cites W2008774890 @default.
• W2801214183 cites W2010319438 @default.
• W2801214183 cites W2011567936 @default.
• W2801214183 cites W2013100565 @default.
• W2801214183 cites W2020366763 @default.
• W2801214183 cites W2024599421 @default.
• W2801214183 cites W2026089421 @default.
• W2801214183 cites W2026152531 @default.
• W2801214183 cites W2036163544 @default.
• W2801214183 cites W2039789837 @default.
• W2801214183 cites W2042476877 @default.
• W2801214183 cites W2047724681 @default.
• W2801214183 cites W2050497029 @default.
• W2801214183 cites W2054417819 @default.
• W2801214183 cites W2059881088 @default.
• W2801214183 cites W2062274509 @default.
• W2801214183 cites W2063880197 @default.
• W2801214183 cites W2070257574 @default.
• W2801214183 cites W2071435977 @default.
• W2801214183 cites W2071833071 @default.
• W2801214183 cites W2073290778 @default.
• W2801214183 cites W2074624875 @default.
• W2801214183 cites W2075246844 @default.
• W2801214183 cites W2075291147 @default.
• W2801214183 cites W2076491580 @default.
• W2801214183 cites W2078286853 @default.
• W2801214183 cites W2081678513 @default.
• W2801214183 cites W2082330618 @default.
• W2801214183 cites W2082807958 @default.
• W2801214183 cites W2082864993 @default.
• W2801214183 cites W2084464242 @default.
• W2801214183 cites W2088049803 @default.
• W2801214183 cites W2088504232 @default.
• W2801214183 cites W2092882523 @default.
• W2801214183 cites W2093684047 @default.
• W2801214183 cites W2095335313 @default.
• W2801214183 cites W2099303289 @default.
• W2801214183 cites W2100221605 @default.
• W2801214183 cites W2101601223 @default.
• W2801214183 cites W2102488526 @default.
• W2801214183 cites W2106365668 @default.
• W2801214183 cites W2107577269 @default.
• W2801214183 cites W2112251383 @default.
• W2801214183 cites W2114841454 @default.
• W2801214183 cites W2116433781 @default.
• W2801214183 cites W2119583980 @default.
• W2801214183 cites W2119850253 @default.
• W2801214183 cites W2125635123 @default.
• W2801214183 cites W2129237305 @default.
• W2801214183 cites W2133711544 @default.
• W2801214183 cites W2139023977 @default.
• W2801214183 cites W2142578013 @default.
• W2801214183 cites W2143768875 @default.
• W2801214183 cites W2144262356 @default.
• W2801214183 cites W2144705128 @default.
• W2801214183 cites W2144829538 @default.
• W2801214183 cites W2145306368 @default.
• W2801214183 cites W2146911856 @default.

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