FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801219006> ?p ?o ?g. }

• W2801219006 abstract "Depression is common in the postnatal period and can lead to adverse effects on the infant and wider family, in addition to the morbidity for the mother. It is not clear whether antidepressants are effective for the prevention of postnatal depression and little is known about possible adverse effects for the mother and infant, particularly during breastfeeding. This is an update of a Cochrane Review last published in 2005.To assess the effectiveness of antidepressant medication for the prevention of postnatal depression, in comparison with any other treatment, placebo or standard care.We searched the Cochrane Common Mental Disorders Controlled Trials Register (CCMDCTR ‒ both Studies and References), CENTRAL (Wiley), MEDLINE (OVID), Embase (OVID), PsycINFO (OVID), on 13 February 2018. We also searched the World Health Organization (WHO) trials portal (ICTRP) and ClinicalTrials.gov on 13 February 2018 to identify any additional unpublished or ongoing studies.Randomised controlled trials (RCTs) of initiation of antidepressants (alone or in combination with another treatment), compared with any other treatment, placebo or standard care for the prevention of postnatal depression among women who were either pregnant or had given birth in the previous six weeks and were not currently depressed at baseline.We used standard methodological procedures expected by Cochrane. We requested missing information from investigators wherever possible and sought data to allow intention-to-treat analyses.Two trials including a total of 81 participants fulfilled the inclusion criteria for this review. All participants in both studies had a history of postnatal depression and were not taking antidepressant medication at baseline. Both trials were conducted by the same research group. Risk of bias was low or unclear in most domains for both studies. We were unable to perform a meta-analysis due to the small number of studies.One study compared nortriptyline with placebo and did not find any evidence that nortriptyline was effective in preventing postnatal depression. In this study, 23% (6/26) of women who took nortriptyline and 24% (6/25) of women who took placebo experienced postnatal depression (RR 0.96, 95% CI 0.36 to 2.59, very low quality evidence) in the first 17 weeks postpartum. One woman taking nortriptyline developed mania; and one side effect, constipation, was more common among women taking nortriptyline than those taking placebo.The second study compared sertraline with placebo. In this study, 7% (1/14) of women who took sertraline developed postnatal depression in the first 17 weeks postpartum compared with 50% (4/8) of women who took placebo. It is uncertain whether sertraline reduces the risk of postnatal depression (RR 0.14, 95% CI 0.02 to 1.07, very low quality evidence). One woman taking sertraline had a hypomanic episode. Two side effects (dizziness and drowsiness) were more common among women taking sertraline than women taking placebo.Conclusions are limited by the small number of studies, small sample sizes and incomplete outcome data due to study drop-out which may have led to bias in the results. We have assessed the certainty of the evidence as very low, based on the GRADE system. No data were available on secondary outcomes of interest including child development, the mother‒infant relationship, breastfeeding, maternal daily functioning, family relationships or maternal satisfaction.Due to the limitations of the current evidence base, such as the low statistical power of the included studies, it is not possible to draw any clear conclusions about the effectiveness of antidepressants for the prevention of postnatal depression. It is striking that no new eligible trials have been completed in the period of over a decade since the last published version of this review. Larger trials are needed which include comparisons of antidepressant drugs with other prophylactic treatments (e.g. psychological interventions), and examine adverse effects for the fetus or infant. Future reviews in this area may benefit from broadening their focus to examine the effectiveness of antidepressants for the prevention of perinatal (i.e. antenatal or postnatal) depression, which could include studies comparing antidepressant discontinuation with continuation for the prevention of relapse of depression during pregnancy and the postnatal period." @default.
• W2801219006 created "2018-05-17" @default.
• W2801219006 creator A5004188950 @default.
• W2801219006 creator A5013457428 @default.
• W2801219006 creator A5014216292 @default.
• W2801219006 creator A5029298548 @default.
• W2801219006 creator A5034723227 @default.
• W2801219006 creator A5084739357 @default.
• W2801219006 date "2018-04-18" @default.
• W2801219006 modified "2023-10-14" @default.
• W2801219006 title "Antidepressants for preventing postnatal depression" @default.
• W2801219006 cites W1481176800 @default.
• W2801219006 cites W1974618278 @default.
• W2801219006 cites W1997986489 @default.
• W2801219006 cites W2004762037 @default.
• W2801219006 cites W2005971163 @default.
• W2801219006 cites W2008044072 @default.
• W2801219006 cites W2013126628 @default.
• W2801219006 cites W2016178055 @default.
• W2801219006 cites W2016972223 @default.
• W2801219006 cites W2027824433 @default.
• W2801219006 cites W2030582855 @default.
• W2801219006 cites W2031362931 @default.
• W2801219006 cites W2049165791 @default.
• W2801219006 cites W2066568484 @default.
• W2801219006 cites W2088095316 @default.
• W2801219006 cites W2091973982 @default.
• W2801219006 cites W2102941960 @default.
• W2801219006 cites W2104302525 @default.
• W2801219006 cites W2108167688 @default.
• W2801219006 cites W2111131859 @default.
• W2801219006 cites W2130235475 @default.
• W2801219006 cites W2130481569 @default.
• W2801219006 cites W2132582193 @default.
• W2801219006 cites W2133308299 @default.
• W2801219006 cites W2138850303 @default.
• W2801219006 cites W2149264570 @default.
• W2801219006 cites W2271952246 @default.
• W2801219006 cites W2300554243 @default.
• W2801219006 cites W2402317814 @default.
• W2801219006 cites W3023792194 @default.
• W2801219006 cites W4232080512 @default.
• W2801219006 cites W4247665917 @default.
• W2801219006 doi "https://doi.org/10.1002/14651858.cd004363.pub3" @default.
• W2801219006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6494522" @default.
• W2801219006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29669175" @default.
• W2801219006 hasPublicationYear "2018" @default.
• W2801219006 type Work @default.
• W2801219006 sameAs 2801219006 @default.
• W2801219006 citedByCount "32" @default.
• W2801219006 countsByYear W28012190062018 @default.
• W2801219006 countsByYear W28012190062019 @default.
• W2801219006 countsByYear W28012190062020 @default.
• W2801219006 countsByYear W28012190062021 @default.
• W2801219006 countsByYear W28012190062022 @default.
• W2801219006 countsByYear W28012190062023 @default.
• W2801219006 crossrefType "journal-article" @default.
• W2801219006 hasAuthorship W2801219006A5004188950 @default.
• W2801219006 hasAuthorship W2801219006A5013457428 @default.
• W2801219006 hasAuthorship W2801219006A5014216292 @default.
• W2801219006 hasAuthorship W2801219006A5029298548 @default.
• W2801219006 hasAuthorship W2801219006A5034723227 @default.
• W2801219006 hasAuthorship W2801219006A5084739357 @default.
• W2801219006 hasBestOaLocation W28012190062 @default.
• W2801219006 hasConcept C118552586 @default.
• W2801219006 hasConcept C126322002 @default.
• W2801219006 hasConcept C139719470 @default.
• W2801219006 hasConcept C142724271 @default.
• W2801219006 hasConcept C162324750 @default.
• W2801219006 hasConcept C168563851 @default.
• W2801219006 hasConcept C17744445 @default.
• W2801219006 hasConcept C187212893 @default.
• W2801219006 hasConcept C197934379 @default.
• W2801219006 hasConcept C199539241 @default.
• W2801219006 hasConcept C204787440 @default.
• W2801219006 hasConcept C27081682 @default.
• W2801219006 hasConcept C2776283161 @default.
• W2801219006 hasConcept C2776478404 @default.
• W2801219006 hasConcept C2776867660 @default.
• W2801219006 hasConcept C2779177272 @default.
• W2801219006 hasConcept C2779234561 @default.
• W2801219006 hasConcept C2779473830 @default.
• W2801219006 hasConcept C2779549880 @default.
• W2801219006 hasConcept C2780262536 @default.
• W2801219006 hasConcept C54355233 @default.
• W2801219006 hasConcept C558461103 @default.
• W2801219006 hasConcept C71924100 @default.
• W2801219006 hasConcept C86803240 @default.
• W2801219006 hasConcept C95190672 @default.
• W2801219006 hasConceptScore W2801219006C118552586 @default.
• W2801219006 hasConceptScore W2801219006C126322002 @default.
• W2801219006 hasConceptScore W2801219006C139719470 @default.
• W2801219006 hasConceptScore W2801219006C142724271 @default.
• W2801219006 hasConceptScore W2801219006C162324750 @default.
• W2801219006 hasConceptScore W2801219006C168563851 @default.
• W2801219006 hasConceptScore W2801219006C17744445 @default.
• W2801219006 hasConceptScore W2801219006C187212893 @default.
• W2801219006 hasConceptScore W2801219006C197934379 @default.
• W2801219006 hasConceptScore W2801219006C199539241 @default.
• W2801219006 hasConceptScore W2801219006C204787440 @default.

• next