FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801227536> ?p ?o ?g. }

• W2801227536 endingPage "1220" @default.
• W2801227536 startingPage "1210" @default.
• W2801227536 abstract "Abstract Background This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. Methods A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score. The score was compared with the current standard (Fong score) and validated in an external cohort of patients from the Memorial Sloan Kettering Cancer Center (MSKCC). Results Six preoperative predictors of worse OS were identified on multivariable Cox regression analysis in the JHH cohort (502 patients). The GAME score was calculated by allocating points to each patient according to the presence of these predictive factors: KRAS-mutated tumours (1 point); carcinoembryonic antigen level 20 ng/ml or more (1 point), primary tumour lymph node metastasis (1 point); Tumour Burden Score between 3 and 8 (1 point) or 9 and over (2 points); and extrahepatic disease (2 points). The high-risk group in the JHH cohort (GAME score at least 4 points) had a 5-year OS rate of 11 per cent, compared with 73·4 per cent for those in the low-risk group (score 0–1 point). Importantly, in cohorts from both the JHH and MSKCC (747 patients), the discriminatory capacity of the GAME score was superior to that of the Fong score, as demonstrated by the C-index and the Akaike information criterion. Conclusion The GAME score is a preoperative prognostic tool that can be used to inform treatment selection." @default.
• W2801227536 created "2018-05-17" @default.
• W2801227536 creator A5006842306 @default.
• W2801227536 creator A5009465403 @default.
• W2801227536 creator A5014748431 @default.
• W2801227536 creator A5016519845 @default.
• W2801227536 creator A5026919131 @default.
• W2801227536 creator A5027065185 @default.
• W2801227536 creator A5027737835 @default.
• W2801227536 creator A5028462034 @default.
• W2801227536 creator A5036762729 @default.
• W2801227536 creator A5042440032 @default.
• W2801227536 creator A5051619233 @default.
• W2801227536 creator A5070056490 @default.
• W2801227536 creator A5070901426 @default.
• W2801227536 creator A5077604478 @default.
• W2801227536 creator A5078198832 @default.
• W2801227536 creator A5079700719 @default.
• W2801227536 creator A5087054171 @default.
• W2801227536 date "2018-04-25" @default.
• W2801227536 modified "2023-10-16" @default.
• W2801227536 title "Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases" @default.
• W2801227536 cites W1495077215 @default.
• W2801227536 cites W1527958696 @default.
• W2801227536 cites W1535319703 @default.
• W2801227536 cites W1553251238 @default.
• W2801227536 cites W1765193236 @default.
• W2801227536 cites W1943526660 @default.
• W2801227536 cites W1966633928 @default.
• W2801227536 cites W1975218692 @default.
• W2801227536 cites W1987403189 @default.
• W2801227536 cites W1989175303 @default.
• W2801227536 cites W1999381305 @default.
• W2801227536 cites W2002952144 @default.
• W2801227536 cites W2007900522 @default.
• W2801227536 cites W2021031183 @default.
• W2801227536 cites W2023887599 @default.
• W2801227536 cites W2037583618 @default.
• W2801227536 cites W2048241019 @default.
• W2801227536 cites W2049036294 @default.
• W2801227536 cites W2063985381 @default.
• W2801227536 cites W2064799866 @default.
• W2801227536 cites W2065935144 @default.
• W2801227536 cites W2074811887 @default.
• W2801227536 cites W2084470612 @default.
• W2801227536 cites W2092679286 @default.
• W2801227536 cites W2097709626 @default.
• W2801227536 cites W2098370829 @default.
• W2801227536 cites W2108687871 @default.
• W2801227536 cites W2115294138 @default.
• W2801227536 cites W2157806587 @default.
• W2801227536 cites W2160535919 @default.
• W2801227536 cites W2170472029 @default.
• W2801227536 cites W2223730291 @default.
• W2801227536 cites W2325443151 @default.
• W2801227536 cites W2414241178 @default.
• W2801227536 cites W2463856396 @default.
• W2801227536 cites W2516740959 @default.
• W2801227536 cites W2521990273 @default.
• W2801227536 cites W2536071775 @default.
• W2801227536 cites W2536674525 @default.
• W2801227536 cites W2546920962 @default.
• W2801227536 cites W2591861689 @default.
• W2801227536 cites W2617980636 @default.
• W2801227536 doi "https://doi.org/10.1002/bjs.10838" @default.
• W2801227536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7988484" @default.
• W2801227536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29691844" @default.
• W2801227536 hasPublicationYear "2018" @default.
• W2801227536 type Work @default.
• W2801227536 sameAs 2801227536 @default.
• W2801227536 citedByCount "97" @default.
• W2801227536 countsByYear W28012275362019 @default.
• W2801227536 countsByYear W28012275362020 @default.
• W2801227536 countsByYear W28012275362021 @default.
• W2801227536 countsByYear W28012275362022 @default.
• W2801227536 countsByYear W28012275362023 @default.
• W2801227536 crossrefType "journal-article" @default.
• W2801227536 hasAuthorship W2801227536A5006842306 @default.
• W2801227536 hasAuthorship W2801227536A5009465403 @default.
• W2801227536 hasAuthorship W2801227536A5014748431 @default.
• W2801227536 hasAuthorship W2801227536A5016519845 @default.
• W2801227536 hasAuthorship W2801227536A5026919131 @default.
• W2801227536 hasAuthorship W2801227536A5027065185 @default.
• W2801227536 hasAuthorship W2801227536A5027737835 @default.
• W2801227536 hasAuthorship W2801227536A5028462034 @default.
• W2801227536 hasAuthorship W2801227536A5036762729 @default.
• W2801227536 hasAuthorship W2801227536A5042440032 @default.
• W2801227536 hasAuthorship W2801227536A5051619233 @default.
• W2801227536 hasAuthorship W2801227536A5070056490 @default.
• W2801227536 hasAuthorship W2801227536A5070901426 @default.
• W2801227536 hasAuthorship W2801227536A5077604478 @default.
• W2801227536 hasAuthorship W2801227536A5078198832 @default.
• W2801227536 hasAuthorship W2801227536A5079700719 @default.
• W2801227536 hasAuthorship W2801227536A5087054171 @default.
• W2801227536 hasBestOaLocation W28012275362 @default.
• W2801227536 hasConcept C11783203 @default.
• W2801227536 hasConcept C121608353 @default.
• W2801227536 hasConcept C126322002 @default.

• next